| Entry |
|
|---|
| Name |
enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific);
acyl-ACP dehydrogenase;
reductase, enoyl-[acyl carrier protein] (reduced nicotinamide
adenine dinucleotide phosphate);
NADPH 2-enoyl Co A reductase;
enoyl acyl-carrier-protein reductase;
enoyl-ACP reductase;
enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific);
acyl-[acyl-carrier-protein]:NADP+ oxidoreductase (B-specific) |
|---|
| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
acyl-[acyl-carrier protein]:NADP+ oxidoreductase (B-specific) |
|---|
| Reaction(IUBMB) |
an acyl-[acyl-carrier protein] + NADP+ = a
trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+
[RN:R01404] |
|---|
| Reaction(KEGG) |
R01404 > R04725 R04956 R04959 R04962 R04967 R04970;
(other) R04430
 |
|---|
| Substrate |
acyl-[acyl-carrier protein] [CPD:C00173];
NADP+ [CPD:C00006] |
|---|
| Product |
trans-2,3-dehydroacyl-[acyl-carrier protein] [CPD:C00693];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Comment |
Catalyses the reduction of enoyl-acyl-[acyl-carrier protein]
derivatives of carbon chain length from 4 to 16. The yeast and
Escherichia coli enzymes are B-specific with respect to NADP+ (cf.
EC 1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH,
A-specific)). |
|---|
| Orthology |
KO: K00209 enoyl-[acyl-carrier-protein] reductase (NADPH2,
B-specific) |
|---|
| Genes |
BXE: Bxe_C0050
MXA: MXAN_6034
FAL: FRAAL4071
CPH: Cpha266_1101
 |
|---|
| Structures |
PDB: 1ULU 2YW9 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:6990992]
Saito K, Kawaguchi A, Okuda S, Seyama Y, Yamakawa T.
Incorporation of hydrogen atoms from deuterated water and
stereospecifically deuterium-labeled nicotin amide nucleotides into
fatty acids with the Escherichia coli fatty acid synthetase system.
Biochim. Biophys. Acta. 618 (1980) 202-13.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:338601]
Seyama Y, Kasama T, Yamakawa T, Kawaguchi A, Saito K.
Origin of hydrogen atoms in the fatty acids synthesized with yeast
fatty acid synthetase.
J. Biochem. (Tokyo). 82 (1977) 1325-9.
Saccharomyces cerevisiae [GN:sce], Brevibacterium ammoniagenes |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:4384650]
Weeks G, Wakil SJ.
Studies on the mechanism of fatty acid synthesis. 18. Preparation
and general properties of the enoyl acyl carrier protein reductases
from Escherichia coli.
J. Biol. Chem. 243 (1968) 1180-9.
Escherichia coli [GN:eco] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.3.1.10
IUBMB Enzyme Nomenclature: 1.3.1.10
ExPASy - ENZYME nomenclature database: 1.3.1.10
BRENDA, the Enzyme Database: 1.3.1.10
CAS: 37251-09-5 |
|---|
