KEGG   ENZYME: 1.3.1.12Help
Entry
EC 1.3.1.12                 Enzyme                                 
Name prephenate dehydrogenase;
hydroxyphenylpyruvate synthase;
chorismate mutase---prephenate dehydrogenase
Class Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname prephenate:NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB) prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH [RN:R01728]
Reaction(KEGG) R01728
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Substrate prephenate [CPD:C00254];
NAD+ [CPD:C00003]
Product 4-hydroxyphenylpyruvate [CPD:C01179];
CO2 [CPD:C00011];
NADH [CPD:C00004]
Comment This enzyme in the enteric bacteria also possesses chorismate mutase
activity (EC 5.4.99.5 chorismate mutase) and converts chorismate
into prephenate.
Pathway PATH: ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
PATH: ec00401  Novobiocin biosynthesis
PATH: ec01100  Metabolic pathways
Orthology KO: K00210  prephenate dehydrogenase
KO: K04517  prephenate dehydrogenase
Genes ECO: b2600(tyrA)
ECJ: JW2581(tyrA)
ECD: ECDH10B_2767(tyrA)
EBW: BWG_2359(tyrA)
ECE: Z3892(tyrA)
ECS: ECs3463(tyrA)
ECF: ECH74115_3839(tyrA)
ETW: ECSP_3545(tyrA)
ECG: E2348C_2874(tyrA)
ECC: c3121(tyrA)
ECI: UTI89_C2933(tyrA)
ECP: ECP_2601(tyrA)
ECV: APECO1_3933(tyrA)
ECW: EcE24377A_2884(tyrA)
ECX: EcHS_A2757(tyrA)
ECM: EcSMS35_2752(tyrA)
ECY: ECSE_2884(tyrA)
ECL: EcolC_1083(tyrA)
ECK: EC55989_2889(tyrA)
ECQ: ECED1_3039(tyrA)
ECR: ECIAI1_2721(tyrA)
ECT: ECIAI39_2804(tyrA)
ECZ: ECS88_2786(tyrA)
EUM: ECUMN_2925(tyrA)
ELF: LF82_2338(tyrA)
EBL: B21_02453(tyrA)
EBD: ECBD_1086
EBR: ECB_02489(tyrA)
EOH: ECO103_3174(tyrA)
EOI: ECO111_3321(tyrA)
EOJ: ECO26_3642(tyrA)
EFE: EFER_0469(tyrA)
STY: STY2856(tyrA)
STT: t2624(tyrA)
SPT: SPA2528(tyrA)
SEK: SSPA2353(tyrA)
SPQ: SPAB_03380(tyrA)
SEI: SPC_2779(tyrA)
SEC: SC2671(tyrA)
SEH: SeHA_C2884(tyrA)
SEE: SNSL254_A2882(tyrA)
SEW: SeSA_A2863(tyrA)
SEA: SeAg_B2813(tyrA)
SED: SeD_A2996(tyrA)
SEG: SG2647(tyrA)
SET: SEN2590(tyrA)
SES: SARI_00258(tyrA)
STM: STM2669(tyrA)
YPE: YPO3285(tyrA)
YPK: y0904(tyrA)
YPM: YP_0399(tyrA)
YPA: YPA_2860(tyrA)
YPN: YPN_0814(tyrA)
YPG: YpAngola_A3483(tyrA)
YPP: YPDSF_2918(tyrA)
YPS: YPTB0842(tyrA)
YPI: YpsIP31758_3219(tyrA)
YPY: YPK_3356(tyrA)
YPB: YPTS_0878(tyrA)
YEN: YE0851(tyrA)
SFL: SF2660(tyrA)
SFX: S2837(tyrA)
SFV: SFV_2871(tyrA)
SSN: SSON_2751(tyrA)
SBO: SBO_2638(tyrA)
SBC: SbBS512_E2987(tyrA)
SDY: SDY_2766(tyrA)
ECA: ECA3351(tyrA)
PCT: PC1_3147
PWA: Pecwa_1132
ETA: ETA_26480(tyrA)
PLU: plu1263(tyrA) plu3562
PAY: PAU_01185(papC) PAU_03198(tyrA)
SGL: SG0579(tyrA)
ENT: Ent638_3079(tyrA)
ESA: ESA_00654(tyrA)
CTU: Ctu_31890(tyrA)
KPN: KPN_02922(tyrA)
KPE: KPK_1199(tyrA)
KPU: KP1_4177(tyrA)
CKO: CKO_03920(tyrA)
SPE: Spro_0880(tyrA)
PMR: PMI0388(tyrA)
EIC: NT01EI_3212
ETR: ETAE_2836(tyrA)
BFL: Bfl178(tyrA)
BPN: BPEN_184(tyrA)
DDA: Dd703_2854
DDC: Dd586_3169
DZE: Dd1591_0998
HIN: HI1290(tyrA)
HIT: NTHI1833(tyrA)
HIP: CGSHiEE_04195(tyrA)
HIQ: CGSHiGG_01505(tyrA)
HAP: HAPS_1273(tyrA)
HSO: HS_0671(tyrA)
HSM: HSM_1080(tyrA)
PMU: PM0664(tyrA)
MSU: MS1102(tyrA)
APL: APL_0184(tyrA)
APJ: APJL_0185(tyrA)
APA: APP7_0186(tyrA)
ASU: Asuc_1569(tyrA)
AAP: NT05HA_0647
AAT: D11S_1242
XFA: XF2338
XFT: PD1368(tyrA)
XFM: Xfasm12_1510
XFN: XfasM23_1453
XCC: XCC1477(tyrA)
XCB: XC_2760
XCA: xccb100_2796
XCV: XCV1567
XAC: XAC1525(tyrA)
XOO: XOO2034(tyrA)
XOM: XOO_1916
XOP: PXO_01188
SML: Smlt1998
SMT: Smal_1605
VCH: VC0696(tyrA)
VCO: VC0395_A0227(tyrA)
VCM: VCM66_0654(tyrA)
VCJ: VCD_003625
VVU: VV1_0494(tyrA)
VVY: VV0702(tyrA)
VPA: VP0547(tyrA)
VHA: VIBHAR_00993(tyrA)
VSP: VS_0548(tyrA)
VEX: VEA_004405
VFI: VF_0554(tyrA)
VFM: VFMJ11_0566(tyrA)
VSA: VSAL_I0654(tyrA)
PPR: PBPRA3025(tyrA)
PAE: PA3164
PPU: PP_1770
PPF: Pput_3944
PST: PSPTO_1748
PSB: Psyr_3644
PSP: PSPPH_3664
PFL: PFL_4310
PFO: Pfl01_4074
PFS: PFLU1770
PEN: PSEEN1490
PAR: Psyc_1184
PCR: Pcryo_1206
ACI: ACIAD2222
ACB: A1S_2276
ABM: ABSDF1252
ABY: ABAYE1207
SON: SO_1362(tyrA)
SDN: Sden_2749(tyrA)
SFR: Sfri_2915(tyrA)
SAZ: Sama_0894(tyrA)
SBL: Sbal_1215(tyrA)
SBM: Shew185_1259(tyrA)
SBN: Sbal195_1292(tyrA)
SBP: Sbal223_3098(tyrA)
SLO: Shew_1068(tyrA)
SPC: Sputcn32_1173(tyrA)
SSE: Ssed_1164(tyrA)
SPL: Spea_1054(tyrA)
SHE: Shewmr4_2833(tyrA)
SHM: Shewmr7_2915(tyrA)
SHN: Shewana3_3012(tyrA)
SHW: Sputw3181_2991(tyrA)
SHL: Shal_1102(tyrA)
SWD: Swoo_1259(tyrA)
SWP: swp_3763(tyrA)
ILO: IL1721(tyrA)
CPS: CPS_3953(tyrA)
PHA: PSHAa0949(tyrA)
PAT: Patl_1588(tyrA)
MAQ: Maqu_1025
AMC: MADE_01712(tyrA)
PIN: Ping_0287(tyrA)
MCA: MCA1416(tyrA)
FTL: FTL_0048
FTH: FTH_0048(tyrA)
FTN: FTN_0055(tyrA)
FPH: Fphi_0779
TCX: Tcr_1195
NOC: Noc_0176
AEH: Mlg_0928
HHA: Hhal_0566
CSA: Csal_2165
ABO: ABO_1747(tyrA)
MMW: Mmwyl1_2857
AHA: AHA_1655(tyrA)
ASA: ASA_2703(tyrA)
TAU: Tola_1377
RMA: Rmag_0624
VOK: COSY_0577
NMA: NMA2045
NME: NMB0440
NMC: NMC1721
NGO: NGO1515
CVI: CV_3407
RSO: RSc0906(tyrA)
RPI: Rpic_0776
RPF: Rpic12D_0847
REU: Reut_A2573
REH: H16_A0794(tyrA)
RME: Rmet_0718
BMA: BMA0430
BMV: BMASAVP1_A2574
BML: BMA10229_A0949
BMN: BMA10247_0199
BPS: BPSL2517(aroA)
BPM: BURPS1710b_2996(aroA)
BPL: BURPS1106A_2947(aroA)
BPD: BURPS668_2884(aroA)
BTE: BTH_I1636
BVI: Bcep1808_0965
BUR: Bcep18194_A4157
BCN: Bcen_0565
BCH: Bcen2424_1044
BCM: Bcenmc03_1003
BAM: Bamb_0920
BXE: Bxe_A0979
BPH: Bphy_0743
PNU: Pnuc_0497
BPE: BP0947(tyrA)
BPA: BPP3131(tyrA)
BBR: BB3470(tyrA)
RFR: Rfer_1568
POL: Bpro_1791
PNA: Pnap_2794
AAV: Aave_3283
AJS: Ajs_2467
VEI: Veis_3122
MPT: Mpe_A2242
HAR: HEAR2577
NEU: NE0337(tyrA)
NET: Neut_1568
NMU: Nmul_A2195
EBA: ebA905(tyrA)
AZO: azo1070(tyrA)
DAR: Daro_1234
TBD: Tbd_0953
MFA: Mfla_0930 Mfla_1074
APP: CAP2UW1_2901
HPY: HP1380
HPJ: jhp1294(tyrA)
HPA: HPAG1_1326
HPP: HPP12_1375(tyrA)
HHE: HH0993(tyrA)
HAC: Hac_0058(tyrA)
WSU: WS0348(tyrA)
TDN: Suden_0659
CJE: Cj0130(tyrA)
CJR: CJE0125(tyrA)
CJJ: CJJ81176_0165(tyrA)
CJU: C8J_0123(tyrA)
CJD: JJD26997_0143(tyrA)
CFF: CFF8240_1500
ABU: Abu_1210(tyrA)
GSU: GSU2607
GME: Gmet_0863
GUR: Gura_1463
GBM: Gbem_3259
GEM: GM21_0991
PCA: Pcar_1886
PPD: Ppro_1346
DVU: DVU0464
DVL: Dvul_2473
DVM: DvMF_1747
DDE: Dde_3485
DDS: Ddes_0334
DSA: Desal_3061
DBA: Dbac_2811
DRT: Dret_0118
DOL: Dole_1946
DAT: HRM2_07590(tyrA)
ADE: Adeh_0183
MXA: MXAN_5840
HOH: Hoch_1368 Hoch_6599
SAT: SYN_01933
PUB: SAR11_0215(tyrA)
MLO: mll3535
MES: Meso_3085
SME: SMc00711(tyrC)
ATU: Atu3611(tyrC)
ATC: AGR_L_2429(tyrC)
RET: RHE_CH03809(tyrC)
RLE: RL4337(tyrC)
BME: BMEI0079
BMF: BAB1_1989
BMB: BruAb1_1964(tyrC)
BMS: BR1988(tyrC)
BOV: BOV_1914(tyrC)
OAN: Oant_0992 Oant_3943
BJA: bll1396(tyrC)
BRA: BRADO6464(tyrC)
BBT: BBta_1182(tyrC)
RPA: RPA4440(tyrC)
RPB: RPB_4255
RPC: RPC_4284
RPD: RPD_4102
RPE: RPE_4343
NWI: Nwi_0582
NHA: Nham_0673
BHE: BH16210(tyrC)
BQU: BQ13130(tyrC)
BTR: Btr_2597(tyrC)
MEX: Mext_1592 Mext_4010
MRD: Mrad2831_1874
MET: M446_5258
MPO: Mpop_1647 Mpop_4492
MCH: Mchl_1873 Mchl_4379
CCR: CC_2224
SIL: SPO3176
SIT: TM1040_2100
RSP: RSP_6215
RSH: Rsph17029_0960
RSQ: Rsph17025_2212
JAN: Jann_1035 Jann_3543
RDE: RD1_3387(tyrC)
PDE: Pden_1408
DSH: Dshi_2945(tyrC)
MMR: Mmar10_0997
HNE: HNE_3400
NAR: Saro_0696
SAL: Sala_2888
ELI: ELI_11420
GOX: GOX2251
GBE: GbCGDNIH1_0139
ACR: Acry_0440
GDI: GDI_1627(tyrA)
GDJ: Gdia_1832
RRU: Rru_A0972 Rru_A3263
MAG: amb3975
MGM: Mmc1_0175
BSU: BSU22610(tyrA)
BHA: BH1666(tyrA)
BAN: BA2954(tyrA)
BAR: GBAA2954(tyrA)
BAA: BA_3463
BAT: BAS2745
BAH: BAMEG_1648(tyrA)
BAI: BAA_3009(tyrA)
BCE: BC2939
BCA: BCE_2995(tyrA)
BCZ: BCZK2674(tyrA)
BCU: BCAH820_2954(tyrA)
BTK: BT9727_2695(tyrA)
BTL: BALH_2642
BWE: BcerKBAB4_2748
BLI: BL02768(tyrA)
BLD: BLi02396(tyrA)
BCL: ABC1902(tyrA)
BAY: RBAM_020770(tyrA)
BPU: BPUM_1992(tyrA)
OIH: OB1781
GKA: GK2197(tyrA)
GTN: GTNG_2131
AFL: Aflv_1108(tyrA)
SAU: SA1197(tyrA)
SAV: SAV1365(tyrA)
SAW: SAHV_1353(tyrA)
SAM: MW1252(tyrA)
SAR: SAR1378
SAS: SAS1305
SAC: SACOL1401(tyrA)
SAB: SAB1220c
SAA: SAUSA300_1260
SAX: USA300HOU_1300(tyrA)
SAO: SAOUHSC_01364
SAJ: SaurJH9_1426
SAH: SaurJH1_1455
SAE: NWMN_1277(tyrA)
SEP: SE1047
SER: SERP0936(tyrA)
SHA: SH1544(tyrA)
SSP: SSP1387
LMO: lmo1924(tyrA)
LMF: LMOf2365_1953(tyrA)
LIN: lin2038
LWE: lwe1950(tyrA)
LSP: Bsph_1964
BBE: BBR47_24800(tyrA)
LLA: L0058(tyrA)
LLC: LACR_1908
LLM: llmg_1927(tyrA)
SPN: SP_1373
SPD: SPD_1207(tyrA)
SPR: spr1231(tyrA)
SPW: SPCG_1363(tyrA)
SPX: SPG_1314(tyrA)
SNE: SPN23F_13390(tyrA)
SPV: SPH_1505
SNM: SP70585_1412
SJJ: SPJ_1273
SPP: SPP_1393
SNT: SPT_0900
SMU: SMU.781
STC: str0642(tyrA)
STL: stu0642(tyrA)
STE: STER_0692
SSA: SSA_1466(tyrA)
SSU: SSU05_1261
SSV: SSU98_1276
SSB: SSUBM407_0691(tyrA)
SSI: SSU1098(tyrA)
SSS: SSUSC84_1131(tyrA)
SGO: SGO_1371
LPL: lp_2034(tyrA)
LFE: LAF_1105
EFA: EF1565
LME: LEUM_1163
LCI: LCK_00702(tyrA)
CAC: CAC0893
CNO: NT01CX_0626
CTH: Cthe_1796
CDF: CD1839(tyrC)
CKL: CKL_0785(tyrA)
CPY: Cphy_2539
CCE: Ccel_2881
AMT: Amet_0646
STH: STH1418
SWO: Swol_1349
ATE: Athe_0844
DSY: DSY2263
DRM: Dred_1150
DAE: Dtox_1009
PTH: PTH_1621(tyrA)
DAU: Daud_1182
HMO: HM1_1926(tyrA)
ERE: EUBREC_1979
TTE: TTE1014(tyrA)
TEX: Teth514_1426
TPD: Teth39_0985
CHY: CHY_0474(tyrA)
MTA: Moth_1333
CSC: Csac_2699
MTU: Rv3754(tyrA)
MTC: MT3861(tyrA)
MRA: MRA_3792(tyrA)
MTF: TBFG_13786
MBO: Mb3780(tyrA)
MBB: BCG_3813(tyrA)
MLE: ML2472
MPA: MAP0277c(tyrA)
MAV: MAV_0321
MSM: MSMEG_6330
MUL: MUL_4372(tyrA)
MVA: Mvan_5596
MGI: Mflv_1212
MAB: MAB_0266c
MMC: Mmcs_4962
MKM: Mkms_5050
MJL: Mjls_5343
MMI: MMAR_5297(tyrA)
CGL: NCgl0223(cgl0226)
CGB: cg0279(tyrA)
CGT: cgR_0300
CEF: CE0195
CDI: DIP0245
CJK: jk2025(tyrA)
NFA: nfa2360
RHA: RHA1_ro04152(tyrA) RHA1_ro06105(tryA)
RER: RER_18470
ROP: ROP_61620
SCO: SCO1761(2SCI34.14c) SCO3221(SCE8.14c)
SMA: SAV_6521(tyrA)
TWH: TWT050(tyrA)
TWS: TW060
LXX: Lxx05720(tyrA)
CMI: CMM_1976
ART: Arth_1535
AAU: AAur_1673
RSA: RSal33209_2591
KRH: KRH_15220(tyrA)
PAC: PPA1208
NCA: Noca_2500
TFU: Tfu_1208
FRA: Francci3_1455 Francci3_2453
FAL: FRAAL2252
ACE: Acel_1235
KRA: Krad_3118
SEN: SACE_0231(tyrA)
STP: Strop_3757
BLO: BL1382(tyrA)
BAD: BAD_1066(tyrA)
LIL: LA1257(tyrA)
LIC: LIC12450(tyrA)
LBJ: LBJ_0933(tyrA)
LBL: LBL_2100(tyrA)
ABA: Acid345_1162
SUS: Acid_7884
BTH: BT_3933
BFR: BF3945
BFS: BF3718
SRU: SRU_1616(tyrA)
CHU: CHU_1274(pdh)
GFO: GFO_0342(tyrA)
FJO: Fjoh_0515
AMU: Amuc_0337
GAU: GAU_1460(tyrA)
RBA: RB5392(tyrA)
SYN: slr2081(tyrA)
SYW: SYNW2058
SYC: syc0868_c(tyrA)
SYF: Synpcc7942_0660
SYD: Syncc9605_0385
SYE: Syncc9902_1945
SYG: sync_0447(tyrA)
SYR: SynRCC307_2107(tyrA)
SYX: SynWH7803_0443(tyrA)
SYP: SYNPCC7002_A0677(tyrA)
CYA: CYA_2300(tyrA)
CYB: CYB_0624(tyrA)
TEL: tll2435(tyrA)
CYT: cce_4463(tyrA)
CYC: PCC7424_2269 PCC7424_4586
GVI: gvip038(tyrA)
ANA: all0418 all1141
NPU: Npun_R0978 Npun_R1269
PMA: Pro1719(tyrA)
PMM: PMM1565
PMT: PMT1724
PMN: PMN2A_1136
PMI: PMT9312_1657
PMB: A9601_17721(tyrA)
PMC: P9515_17521(tyrA)
PMF: P9303_22941(tyrA)
PMG: P9301_17561(tyrA)
PME: NATL1_20101(tyrA)
TER: Tery_2701
CTE: CT0084(tyrA)
CCH: Cag_0018
CPH: Cpha266_2572
PVI: Cvib_1692
PLT: Plut_2049
DET: DET0460
DEH: cbdb_A423
DEB: DehaBAV1_0437
RRS: RoseRS_2023
RCA: Rcas_2997
CAU: Caur_2517
CAG: Cagg_3803
CHL: Chy400_2718
HAU: Haur_4079
TRO: trd_1569
DRA: DR_1122
DGE: Dgeo_1040
TTJ: TTHA0799
AAE: aq_1755(tyrA)
SAF: SULAZ_0159
TMA: TM0344
TPT: Tpet_0576
MJA: MJ0612
MFE: Mefer_0217
MVU: Metvu_1180
MMP: MMP1514(tyrA)
MMQ: MmarC5_0061
MMX: MmarC6_1158
MMZ: MmarC7_0760
MAE: Maeo_1024
MVN: Mevan_0827
MAC: MA4595
MBA: Mbar_A0924
MMA: MM_1275
MBU: Mbur_1997
MTP: Mthe_1502
MHU: Mhun_1033
MLA: Mlab_0599
MEM: Memar_1300
MBN: Mboo_1560
MPL: Mpal_2608
MTH: MTH1640
MST: Msp_1083
MSI: Msm_0641
MKA: MK0798(tyrA_2)
HAL: VNG1235C
HSL: OE2770F(tyrA)
HMA: rrnAC0512(tyrA)
HWA: HQ3352A(tyrA)
NPH: NP3358A(tyrA)
HLA: Hlac_1779
TAC: Ta0246m
TVO: TVN1350
PTO: PTO0836
PFU: PF1703
TKO: TK0259
TON: TON_1142
RCI: RCIX1314(tyrA)
IHO: Igni_0892
SIS: LS215_1939
SIA: M1425_1799
SIM: M1627_1917
SID: M164_1847
SIY: YG5714_1916
SIN: YN1551_1009
PIS: Pisl_1785
PCL: Pcal_0890
PAS: Pars_2024
CMA: Cmaq_0808
TNE: Tneu_0799
Taxonomy
Structures PDB: 2G5C  2PV7  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:5456988]
Koch GL, Shaw DC, Gibson F.
Tyrosine biosynthesis in Aerobacter aerogenes. Purification and
properties of chorismate mutase-prephenate dehydrogenase.
Biochim. Biophys. Acta. 212 (1970) 375-86.
Klebsiella pneumoniae [GN:kpn]
Other DBs ExplorEnz - The Enzyme Database: 1.3.1.12
IUBMB Enzyme Nomenclature: 1.3.1.12
ExPASy - ENZYME nomenclature database: 1.3.1.12
BRENDA, the Enzyme Database: 1.3.1.12
CAS: 9044-92-2
DBGET integrated database retrieval system