| Entry |
|
|---|
| Name |
orotate reductase (NADH);
orotate reductase (NADH) |
|---|
| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
(S)-dihydroorotate:NAD+ oxidoreductase |
|---|
| Reaction(IUBMB) |
(S)-dihydroorotate + NAD+ = orotate + NADH + H+ [RN:R01869] |
|---|
| Reaction(KEGG) |
R01869
 |
|---|
| Substrate |
(S)-dihydroorotate [CPD:C00337];
NAD+ [CPD:C00003] |
|---|
| Product |
orotate [CPD:C00295];
NADH [CPD:C00004];
H+ [CPD:C00080] |
|---|
| Cofactor |
FAD [CPD:C00016];
FMN [CPD:C00061] |
|---|
| Comment |
A flavoprotein (FAD, FMN). |
|---|
| Pathway |
PATH: ec00240 Pyrimidine metabolism
PATH: ec01100 Metabolic pathways |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13610849]
FRIEDMANN HC, VENNESLAND B.
Purification and properties of dihydro-orotic dehydrogenase.
J. Biol. Chem. 233 (1958) 1398-406.
Zymobacterium oroticum |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:13825167]
FRIEDMANN HC, VENNESLAND B.
Crystalline dihydroorotic dehydrogenase.
J. Biol. Chem. 235 (1960) 1526-32.
Zymobacterium oroticum |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13115431]
LIEBERMAN I, KORNBERG A.
Enzymic synthesis and breakdown of a pyrimidine, orotic acid. I.
Dihydro-orotic dehydrogenase.
Biochim. Biophys. Acta. 12 (1953) 223-34.
Zymobacterium oroticum |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.3.1.14
IUBMB Enzyme Nomenclature: 1.3.1.14
ExPASy - ENZYME nomenclature database: 1.3.1.14
BRENDA, the Enzyme Database: 1.3.1.14
CAS: 37255-26-8 |
|---|
