KEGG   ENZYME: 1.3.1.2Help
Entry
EC 1.3.1.2                  Enzyme                                 
Name dihydropyrimidine dehydrogenase (NADP+);
dihydrothymine dehydrogenase;
dihydrouracil dehydrogenase (NADP+);
4,5-dihydrothymine: oxidoreductase;
DPD;
DHPDH;
dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide
phosphate);
dihydrouracil dehydrogenase (NADP+);
DHU dehydrogenase;
hydropyrimidine dehydrogenase;
dihydropyrimidine dehydrogenase (NADP+)
Class Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname 5,6-dihydrouracil:NADP+ 5-oxidoreductase
Reaction(IUBMB) 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+ [RN:R00978]
Reaction(KEGG) R00978;
(other) R01415 R08226
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Substrate 5,6-dihydrouracil [CPD:C00429];
NADP+ [CPD:C00006]
Product uracil [CPD:C00106];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment Also acts on dihydrothymine.
Pathway PATH: ec00240  Pyrimidine metabolism
PATH: ec00410  beta-Alanine metabolism
PATH: ec00770  Pantothenate and CoA biosynthesis
PATH: ec00983  Drug metabolism - other enzymes
PATH: ec01100  Metabolic pathways
Orthology KO: K00207  dihydropyrimidine dehydrogenase (NADP+)
Genes HSA: 1806(DPYD)
PTR: 457047(DPYD)
MCC: 715672(DPYD)
MMU: 99586(Dpyd)
RNO: 81656(Dpyd)
CFA: 479935(DPYD)
BTA: 281124(DPYD)
SSC: 397109(DPYD)
ECB: 100057177(DPYD)
MDO: 100032923
GGA: 429083(DPYD)
TGU: 100222559
XLA: 447312
DRE: 405829(dpyd)
BFO: BRAFLDRAFT_129513
CIN: 100175681
SPU: 575768 758949
DME: Dmel_CG2194(su(r))
DPO: Dpse_GA15293
AME: 410207
CEL: C25F6.3(dpyd-1)
NVE: NEMVE_v1g190441
OSA: 4330657(Os02g0736400)
DDI: DDB_0231100(pyd1)
TET: TTHERM_01250100
PAE: PA0439
PAU: PA14_05740(pydA)
PPU: PP_4038
PFL: PFL_2546
PFO: Pfl01_3443
BXE: Bxe_A1429
PNA: Pnap_4020
AAV: Aave_0967
VEI: Veis_4151
MLO: mll1643
MES: Meso_2055
SME: SMc01815
BMF: BAB1_0313
BMS: BR0282
BBT: BBta_6035
SIL: SPO1777
SIT: TM1040_1500
RSQ: Rsph17025_1458
SUS: Acid_7660
HMA: rrnAC0052(dpd)
Taxonomy
Structures PDB: 1GT8  1GTE  1GTH  1H7W  1H7X  
Reference
  Authors
  Title
  Journal
  Organism
 1  [PMID:13825299]
FRITZSON P.
Properties and assay of dihydrouracil dehydrogenase of rat liver.
J. Biol. Chem. 235 (1960) 719-25.
Rattus norvegicus [GN:rno]
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:7451435]
Shiotani T, Weber G.
Purification and properties of dihydrothymine dehydrogenase from rat
liver.
J. Biol. Chem. 256 (1981) 219-24.
Rattus norvegicus [GN:rno]
Other DBs ExplorEnz - The Enzyme Database: 1.3.1.2
IUBMB Enzyme Nomenclature: 1.3.1.2
ExPASy - ENZYME nomenclature database: 1.3.1.2
BRENDA, the Enzyme Database: 1.3.1.2
CAS: 9029-01-0
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