KEGG   ENZYME: 1.3.1.21Help
Entry
EC 1.3.1.21                 Enzyme                                 

Name
7-dehydrocholesterol reductase;
DAF-36 (gene name);
DHCR7 (gene name);
7-DHC reductase;
7-dehydrocholesterol dehydrogenase/cholesterol oxidase;
Delta7-sterol reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
cholesterol:NADP+ Delta7-oxidoreductase
Reaction(IUBMB)
cholesterol + NADP+ = cholesta-5,7-dien-3beta-ol + NADPH + H+ [RN:R01456]
Reaction(KEGG)
Substrate
cholesterol [CPD:C00187];
NADP+ [CPD:C00006]
Product
cholesta-5,7-dien-3beta-ol [CPD:C01164];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
In mammals the enzyme is part of the cholesterol biosynthesis pathway [2] and catalyses the reduction reaction. In the nematode Caenorhabditis elegans the enzyme catalyses the oxidation reaction as part of the biosynthesis of dafachronic acids that are important for control of developmental timing and longevity [3,4].
History
EC 1.3.1.21 created 1972, modified 2013
Pathway
Steroid biosynthesis
Insect hormone biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K00213  
7-dehydrocholesterol reductase
K14938  
cholesterol 7-dehydrogenase
Genes
HSA: 
1717(DHCR7)
PTR: 
451393(DHCR7)
PPS: 
100977099(DHCR7)
GGO: 
101137517(DHCR7)
PON: 
100172090(DHCR7)
NLE: 
100580795(DHCR7)
MCF: 
102120769(DHCR7)
CJC: 
100414321(DHCR7)
MMU: 
13360(Dhcr7)
RNO: 
64191(Dhcr7)
CGE: 
100771700(Dhcr7)
NGI: 
HGL: 
101703035(Dhcr7)
TUP: 
102493586(DHCR7)
CFA: 
483675(DHCR7)
AML: 
100467495(DHCR7)
UMR: 
103671131(DHCR7)
FCA: 
101089143(DHCR7)
PTG: 
102956988(DHCR7)
BTA: 
514745(DHCR7)
BOM: 
102276304(DHCR7)
PHD: 
102315903(DHCR7)
CHX: 
102171848(DHCR7)
OAS: 
101118320(DHCR7)
SSC: 
CFR: 
102517817(DHCR7)
BACU: 
103016099(DHCR7)
LVE: 
103089128(DHCR7)
ECB: 
100061433(DHCR7)
MYD: 
102760533(DHCR7)
PALE: 
MDO: 
100017714(DHCR7)
SHR: 
100914156(DHCR7)
OAA: 
100074666(DHCR7)
GGA: 
422982(DHCR7) 427775
MGP: 
APLA: 
TGU: 
100230558(DHCR7)
FAB: 
PHI: 
102100206(DHCR7)
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
379273(dhcr7) 779348(MGC154819)
XTR: 
DRE: 
378446(dhcr7) 436885(Neverland)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
100176643 100177386(Neverland)
SPU: 
DME: 
DER: 
DSE: 
DSI: 
DWI: 
AGA: 
AAG: 
CQU: 
BMOR: 
733067(Nvd)
API: 
PHU: 
ISC: 
CEL: 
CELE_C12D8.5(daf-36)
CBR: 
CBG09553(Cbr-daf-36)
LOA: 
HRO: 
LGI: 
NVE: 
AQU: 
ATH: 
AT1G50430(DWF5)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
CMO: 
RCU: 
POP: 
POPTR_0008s00580g(POPTRDRAFT_765023) POPTR_0010s25970g(POPTRDRAFT_833904) POPTR_0010s25980g(POPTRDRAFT_567775)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os02t0465400-01(Os02g0465400)
OBR: 
BDI: 
SBI: 
SORBI_04g017400(SORBIDRAFT_04g017400)
ZMA: 
100282098(pco110886)
SITA: 
PDA: 
ATR: 
s00025p00164700(AMTR_s00025p00164700)
SMO: 
PPP: 
BPG: 
MIS: 
MPP: 
CSL: 
CCP: 
MGR: 
FGR: 
NHE: 
CMT: 
VAL: 
SSL: 
AOR: 
AOR_1_288164(AO090001000167)
AFV: 
ACT: 
PCS: 
PBL: 
AJE: 
PTE: 
PFJ: 
NPA: 
TML: 
MBR: 
ACAN: 
PTI: 
TPS: 
PIF: 
EHX: 
GTT: 
NGR: 
CBU: 
CBS: 
CBD: 
CBC: 
LLO: 
PCU: 
pc1220(dhcR7)
PUV: 
PUV_11120(DWF5)
WCH: 
wcw_1842(dhcr7)
 » show all
Taxonomy
Reference
1  [PMID:14189869]
  Authors
DEMPSEY ME, SEATON JD, SCHROEPFER GJ Jr, TROCKMAN RW.
  Title
THE INTERMEDIARY ROLE OF DELTA-5,7-CHOLESTADIEN-3-BETA-OL IN CHOLESTEROL BIOSYNTHESIS.
  Journal
J. Biol. Chem. 239 (1964) 1381-7.
Reference
2  [PMID:9465114]
  Authors
Moebius FF, Fitzky BU, Lee JN, Paik YK, Glossmann H
  Title
Molecular cloning and expression of the human delta7-sterol reductase.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 1899-902.
  Sequence
[hsa:1717]
Reference
3  [PMID:21632547]
  Authors
Yoshiyama-Yanagawa T, Enya S, Shimada-Niwa Y, Yaguchi S, Haramoto Y, Matsuya T, Shiomi K, Sasakura Y, Takahashi S, Asashima M, Kataoka H, Niwa R
  Title
The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol-metabolizing enzyme.
  Journal
J. Biol. Chem. 286 (2011) 25756-62.
  Sequence
Reference
4  [PMID:21749634]
  Authors
Wollam J, Magomedova L, Magner DB, Shen Y, Rottiers V, Motola DL, Mangelsdorf DJ, Cummins CL, Antebi A
  Title
The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity.
  Journal
Aging. Cell. 10 (2011) 879-84.
  Sequence
Reference
5  [PMID:23603937]
  Authors
Najle SR, Nusblat AD, Nudel CB, Uttaro AD
  Title
The Sterol-C7 desaturase from the ciliate Tetrahymena thermophila is a Rieske Oxygenase, which is highly conserved in animals.
  Journal
Mol. Biol. Evol. 30 (2013) 1630-43.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9080-21-1

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