| Entry |
|
|---|
| Name |
7-dehydrocholesterol reductase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
cholesterol:NADP+ Delta7-oxidoreductase |
|---|
| Reaction(IUBMB) |
cholesterol + NADP+ = cholesta-5,7-dien-3beta-ol + NADPH + H+
[RN:R01456] |
|---|
| Reaction(KEGG) |
R01456;
(other) R01451
 |
|---|
| Substrate |
cholesterol [CPD:C00187];
NADP+ [CPD:C00006] |
|---|
| Product |
cholesta-5,7-dien-3beta-ol [CPD:C01164];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Pathway |
PATH: ec00100 Steroid biosynthesis
PATH: ec01062 Biosynthesis of terpenoids and steroids
PATH: ec01066 Biosynthesis of alkaloids derived from terpenoid and
polyketide
PATH: ec01070 Biosynthesis of plant hormones
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00213 7-dehydrocholesterol reductase |
|---|
| Genes |
HSA: 1717(DHCR7)
PTR: 451393(DHCR7)
MCC: 707762(DHCR7)
MMU: 13360(Dhcr7)
RNO: 64191(Dhcr7)
CFA: 483675(DHCR7)
BTA: 514745(DHCR7)
ECB: 100061433(DHCR7)
OAA: 100074666
GGA: 422982(DHCR7)
TGU: 100230558
XLA: 379273(xdhcr7)
XTR: 394844(dhcr7)
DRE: 378446(dhcr7)
NVE: NEMVE_v1g229921
ATH: AT1G50430(DWF5)
OSA: 4329318(Os02g0465400)
AOR: AO090003000792
PCU: pc1220(dhcR7)
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:14189869]
DEMPSEY ME, SEATON JD, SCHROEPFER GJ Jr, TROCKMAN RW.
THE INTERMEDIARY ROLE OF DELTA-5,7-CHOLESTADIEN-3-BETA-OL IN
CHOLESTEROL BIOSYNTHESIS.
J. Biol. Chem. 239 (1964) 1381-7.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.3.1.21
IUBMB Enzyme Nomenclature: 1.3.1.21
ExPASy - ENZYME nomenclature database: 1.3.1.21
BRENDA, the Enzyme Database: 1.3.1.21
CAS: 9080-21-1 |
|---|
