| Entry |
|
|---|
| Name |
1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase;
3,5-cyclohexadiene-1,2-diol-1-carboxylate dehydrogenase;
3,5-cyclohexadiene-1,2-diol-1-carboxylic acid dehydrogenase;
dihydrodihydroxybenzoate dehydrogenase;
DHBDH;
cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase;
2-hydro-1,2-dihydroxybenzoate dehydrogenase;
cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD+
oxidoreductase;
dihydrodihydroxybenzoate dehydrogenase;
(1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+
oxidoreductase (decarboxylating) |
|---|
| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+
oxidoreductase (decarboxylating) |
|---|
| Reaction(IUBMB) |
(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD+ =
catechol + CO2 + NADH + H+ [RN:R00813] |
|---|
| Reaction(KEGG) |
R00813;
(other) R08111 R08112 R08113
 |
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| Substrate |
(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate [CPD:C06321];
NAD+ [CPD:C00003] |
|---|
| Product |
catechol [CPD:C00090];
CO2 [CPD:C00011];
NADH [CPD:C00004];
H+ [CPD:C00080] |
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| Pathway |
PATH: ec00362 Benzoate degradation via hydroxylation
PATH: ec00364 Fluorobenzoate degradation
PATH: ec00632 Benzoate degradation via CoA ligation
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K05783 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate
dehydrogenase |
|---|
| Genes |
EFE: EFER_1485(benD)
KPN: KPN_01869(benD)
KPE: KPK_2488(benD)
KPU: KP1_2934
PAE: PA2515(benD)
PAU: PA14_32130(benD)
PAP: PSPA7_2722(benD)
PAG: PLES_27801(benD)
PPU: PP_3164(benD)
PPF: Pput_2551(benD)
PPG: PputGB1_2685(benD)
PPW: PputW619_2707(benD)
PFL: PFL_3855(benD)
PFO: Pfl01_2324(benD) Pfl01_2965(benD)
PEN: PSEEN3140(benD)
PSA: PST_1670(benD)
AVN: Avin_08620(benD)
PCR: Pcryo_1264(benD)
ACI: ACIAD1439(benD)
ACB: A1S_1212(benD)
ABY: ABAYE2558(benD)
ABC: ACICU_01189(benD)
ABN: AB57_1347(benD)
ABB: ABBFA_002367(benD)
RPI: Rpic_1367(benD)
RPF: Rpic12D_1431
REU: Reut_B4406(benD)
REH: H16_A1960(benD)
RME: Rmet_4885(benD)
BMA: BMAA0184(benD)
BMV: BMASAVP1_1357(benD)
BML: BMA10229_1553(benD)
BMN: BMA10247_A0212(benD)
BPS: BPSS1906(benD)
BPM: BURPS1710b_A1002(benD)
BPL: BURPS1106A_A2584(benD)
BPD: BURPS668_A2728(benD)
BTE: BTH_II0470(benD)
BVI: Bcep1808_5828(benD)
BUR: Bcep18194_C7049(benD)
BCN: Bcen_1303(benD)
BCH: Bcen2424_6527(benD)
BCM: Bcenmc03_6134(benD)
BAM: Bamb_6581(benD)
BAC: BamMC406_6296(benD)
BMU: Bmul_3241(benD)
BMJ: BMULJ_05284(benD)
BXE: Bxe_B0912(benD)
BPH: Bphy_5349(benD)
BPY: Bphyt_1594(benD)
BPT: Bpet1396(benD)
PNA: Pnap_2109(benD)
DAR: Daro_2781(benD)
ARA: Arad_12206
XAU: Xaut_4355
MET: M446_1327(benD)
MNO: Mnod_2371
PDE: Pden_1180(benD)
NAR: Saro_0540(benD) Saro_3837(benD)
SWI: Swit_2636(benD)
CGL: NCgl2323(benD)
CGB: cg2640(benD)
CGT: cgR_2288(benD)
CEF: CE2308(benD)
RHA: RHA1_ro02387(benD)
ROP: ROP_21010(benD)
 |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:4341530]
Reiner AM.
Metabolism of aromatic compounds in bacteria. Purification and
properties of the catechol-forming enzyme,
3,5-cyclohexadiene-1,2-diol-1-carboxylic acid (NAD + )
oxidoreductase (decarboxylating).
J. Biol. Chem. 247 (1972) 4960-5.
Alcaligenes eutrophus |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:1740120]
Neidle E, Hartnett C, Ornston LN, Bairoch A, Rekik M, Harayama S.
cis-diol dehydrogenases encoded by the TOL pWW0 plasmid xylL gene
and the Acinetobacter calcoaceticus chromosomal benD gene are
members of the short-chain alcohol dehydrogenase superfamily.
Eur. J. Biochem. 204 (1992) 113-20.
Pseudomonas putida, Acinetobacter calcoaceticus |
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| Other DBs |
ExplorEnz - The Enzyme Database: 1.3.1.25
IUBMB Enzyme Nomenclature: 1.3.1.25
ExPASy - ENZYME nomenclature database: 1.3.1.25
UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.25
BRENDA, the Enzyme Database: 1.3.1.25
CAS: 60496-16-4 |
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