| Entry |
|
|---|
| Name |
progesterone 5alpha-reductase;
steroid 5-alpha-reductase;
Delta4-steroid 5alpha-reductase (progesterone) |
|---|
| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
5alpha-pregnan-3,20-dione:NADP+ 5-oxidoreductase |
|---|
| Reaction(IUBMB) |
5alpha-pregnan-3,20-dione + NADP+ = progesterone + NADPH + H+
[RN:R02208] |
|---|
| Reaction(KEGG) |
R02208;
(other) R08954
 |
|---|
| Substrate |
5alpha-pregnan-3,20-dione;
NADP+ [CPD:C00006] |
|---|
| Product |
progesterone [CPD:C00410];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Comment |
Testosterone and 20alpha-hydroxy-4-pregn-3-one can act in place of
progesterone. |
|---|
| Pathway |
PATH: ec00140 Steroid hormone biosynthesis |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:240847]
Cheng YJ, Karavolas HJ.
Subcellular distribution and properties of progesterone
(delta4-steroid) 5alpha-reductase in rat medial basal hypothalamus.
J. Biol. Chem. 250 (1975) 7997-8003.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:1166484]
Cheng YJ, Karavolas HJ.
Properties and subcellular distribution of delta4-steroid
(progesterone) 5alpha-reductase in rat anterior pituitary.
Steroids. 26 (1975) 57-71.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.3.1.30
IUBMB Enzyme Nomenclature: 1.3.1.30
ExPASy - ENZYME nomenclature database: 1.3.1.30
BRENDA, the Enzyme Database: 1.3.1.30
CAS: 72412-84-1 |
|---|
