| Entry |
|
|---|
| Name |
arogenate dehydrogenase;
arogenic dehydrogenase (ambiguous);
cyclohexadienyl dehydrogenase;
pretyrosine dehydrogenase (ambiguous);
L-arogenate:NAD+ oxidoreductase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
L-arogenate:NAD+ oxidoreductase (decarboxylating) |
|---|
| Reaction(IUBMB) |
L-arogenate + NAD+ = L-tyrosine + NADH + CO2 [RN:R00732] |
|---|
| Reaction(KEGG) |
R00732
 |
|---|
| Substrate |
L-arogenate [CPD:C00826];
NAD+ [CPD:C00003] |
|---|
| Product |
L-tyrosine [CPD:C00082];
NADH [CPD:C00004];
CO2 [CPD:C00011] |
|---|
| Comment |
See also EC 1.3.1.12 (prephenate dehydrogenase), EC 1.3.1.78
[arogenate dehydrogenase (NADP+)] and EC 1.3.1.79 (arogenate
dehydrogenase [NAD(P)+]). |
|---|
| Pathway |
PATH: ec00400 Phenylalanine, tyrosine and tryptophan biosynthesis
PATH: ec00401 Novobiocin biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00220 cyclohexadienyl dehydrogenase |
|---|
| Genes |
ACI: ACIAD2222
ACB: A1S_2276
ABM: ABSDF1252
ABY: ABAYE1207
MLO: mll3535
MES: Meso_3085
SME: SMc00711(tyrC)
ATU: Atu3611(tyrC)
ATC: AGR_L_2429(tyrC)
RLE: RL4337(tyrC)
BME: BMEI0079
BMF: BAB1_1989
BMB: BruAb1_1964(tyrC)
BMS: BR1988(tyrC)
BOV: BOV_1914(tyrC)
OAN: Oant_0992
BHE: BH16210(tyrC)
BQU: BQ13130(tyrC)
BTR: Btr_2597(tyrC)
CCR: CC_2224
SIL: SPO3176
ZMO: ZMO0420
GOX: GOX2251
 |
|---|
| Structures |
PDB: 2F1K |
|---|
Reference
Authors
Title
Journal
|
1 [PMID:4206476]
Stenmark SL, Pierson DL, Jensen RA, Glover GI.
Blue-green bacteria synthesise L-tyrosine by the pretyrosine
pathway.
Nature. 247 (1974) 290-2. |
|---|
Reference
Authors
Title
Journal
|
2
Byng, G., Whitaker, R., Flick, C. and Jensen, R.A.
Enzymology of L-tyrosine biosynthesis in corn (Zea mays).
Phytochemistry 20 (1981) 1289-1292. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:3967752]
Mayer E, Waldner-Sander S, Keller B, Keller E, Lingens F.
Purification of arogenate dehydrogenase from Phenylobacterium
immobile.
FEBS. Lett. 179 (1985) 208-12.
Phenylobacterium immobile |
|---|
Reference
Authors
Title
Journal
|
4
Lingens, F., Keller, E. and Keller, B.
Arogenate dehydrogenase from Phenylobacterium immobile.
Methods Enzymol. 142 (1987) 513-518. |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:2972718]
Zamir LO, Tiberio R, Devor KA, Sauriol F, Ahmad S, Jensen RA.
Structure of D-prephenyllactate. A carboxycyclohexadienyl metabolite
from Neurospora crassa.
J. Biol. Chem. 263 (1988) 17284-90.
Klebsiella pneumoniae |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.3.1.43
IUBMB Enzyme Nomenclature: 1.3.1.43
ExPASy - ENZYME nomenclature database: 1.3.1.43
BRENDA, the Enzyme Database: 1.3.1.43
CAS: 64295-75-6 |
|---|
