KEGG   ENZYME: 1.3.1.45Help
Entry
EC 1.3.1.45                 Enzyme                                 

Name
2'-hydroxyisoflavone reductase;
NADPH:2'-hydroxyisoflavone oxidoreductase;
isoflavone reductase;
2',7-dihydroxy-4',5'-methylenedioxyisoflavone reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
vestitone:NADP+ oxidoreductase
Reaction(IUBMB)
vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+ [RN:R06562]
Reaction(KEGG)
Substrate
vestitone [CPD:C00786];
NADP+ [CPD:C00006]
Product
2'-hydroxyformononetin [CPD:C02920];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
In the reverse reaction, a 2'-hydroxyisoflavone is reduced to an isoflavanone; 2'-hydroxypseudobaptigenin also acts. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain.
History
EC 1.3.1.45 created 1990
Pathway
Isoflavonoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K05281  
2'-hydroxyisoflavone reductase
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Taxonomy
Reference
1
  Authors
Tiemann, K., Hinderer, W. and Barz, W.
  Title
Isolation of NADPH:isoflavone oxidoreductase, a new enzyme of pterocarpan biosynthesis in cell suspensions of Cicer arietinum.
  Journal
FEBS Lett. 213 (1987) 324-328.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
128449-69-4

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