KEGG   ENZYME: 1.3.1.45Help
Entry
EC 1.3.1.45                 Enzyme                                 
Name
2'-hydroxyisoflavone reductase;
NADPH:2'-hydroxyisoflavone oxidoreductase;
isoflavone reductase;
2',7-dihydroxy-4',5'-methylenedioxyisoflavone reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
vestitone:NADP+ oxidoreductase
Reaction(IUBMB)
vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+ [RN:R06562]
Reaction(KEGG)
Substrate
vestitone [CPD:C00786];
NADP+ [CPD:C00006]
Product
2'-hydroxyformononetin [CPD:C02920];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
In the reverse reaction, a 2'-hydroxyisoflavone is reduced to an isoflavanone; 2'-hydroxypseudobaptigenin also acts. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain.
Pathway
Isoflavonoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K05281  
2'-hydroxyisoflavone reductase
Genes
MXA: 
SUR: 
BAN: 
BAR: 
BAT: 
BAH: 
BAI: 
BAL: 
BCE: 
BCZ: 
BCR: 
BCAH187_A3080
BCB: 
BCB4264_A3050
BCU: 
BCAH820_3063
BCG: 
BCG9842_B2200
BCQ: 
BCQ_2858
BCX: 
BCA_3114
BCY: 
Bcer98_2039
BTK: 
BT9727_2810
BTL: 
BALH_2726
BTB: 
BMB171_C2740
BWE: 
BcerKBAB4_2833
 » show all
Taxonomy
Reference
1
  Authors
Tiemann, K., Hinderer, W. and Barz, W.
  Title
Isolation of NADPH:isoflavone oxidoreductase, a new enzyme of pterocarpan biosynthesis in cell suspensions of Cicer arietinum.
  Journal
FEBS Lett. 213 (1987) 324-328.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
128449-69-4
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