KEGG   ENZYME: 1.3.1.54Help
Entry
EC 1.3.1.54                 Enzyme                                 
Name precorrin-6A reductase;
precorrin-6X reductase;
precorrin-6Y:NADP+ oxidoreductase
Class Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname precorrin-6B:NADP+ oxidoreductase
Reaction(IUBMB) precorrin-6B + NADP+ = precorrin-6A + NADPH + H+ [RN:R05150]
Reaction(KEGG) R05150;
(other) R05812
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Substrate precorrin 6B [CPD:C06319];
NADP+ [CPD:C00006]
Product precorrin 6A [CPD:C06320];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Pathway PATH: ec00860  Porphyrin and chlorophyll metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K05895  precorrin-6X reductase
Genes STY: STY2231(cbiJ)
STT: t0848(cbiJ)
SPT: SPA0845(cbiJ)
SEK: SSPA0790
SPQ: SPAB_01079
SEI: SPC_1689(cbiJ)
SEC: SC2034(cbiJ)
SEH: SeHA_C2248(cobK)
SEE: SNSL254_A2202(cobK)
SEW: SeSA_A2195(cobK)
SEA: SeAg_B2148(cobK)
SED: SeD_A2361(cobK)
SEG: SG2051(cbiJ)
SET: SEN2024(cbiJ)
SES: SARI_00862
STM: STM2026(cbiJ)
YEN: YE2717(cbiJ)
PLU: plu2990(cbiJ)
PAY: PAU_01610(cbiJ)
KPN: KPN_03191(cbiJ)
KPE: KPK_0925(cobK)
KPU: KP1_4456
CKO: CKO_00812
EIC: NT01EI_2184
ETR: ETAE_1995(cbiJ)
PAE: PA2909
PAU: PA14_26460(cobK)
PAP: PSPA7_2245
PAG: PLES_21551(cobK)
PPU: PP_4832(cobK)
PPF: Pput_4710(cbiJ)
PPG: PputGB1_4888
PPW: PputW619_4622
PST: PSPTO_4880
PSB: Psyr_4420(cbiJ)
PSP: PSPPH_4463(cbiJ)
PFL: PFL_0654(cobK)
PFO: Pfl01_0601(cbiJ)
PFS: PFLU0602(cobK)
PEN: PSEEN4874(cobK)
PMY: Pmen_4569
HHA: Hhal_1927
HCH: HCH_06470(cobK)
MMW: Mmwyl1_3377
TAU: Tola_1672
CVI: CV_1562(cbiJ)
RSO: RSp0618(cbiJH)
BMA: BMA1158(cobK)
BMV: BMASAVP1_A1599(cobK)
BML: BMA10229_A0260
BMN: BMA10247_0900(cobK)
BPS: BPSL1756(cobK)
BPM: BURPS1710b_2116(cobK)
BPL: BURPS1106A_1971(cobK)
BPD: BURPS668_1954(cobK)
BPR: GBP346_A1996(cobK)
BTE: BTH_I2395(cobK)
BVI: Bcep1808_1613
BUR: Bcep18194_A4828(cbiJ)
BCN: Bcen_1197(cobK)
BCH: Bcen2424_1677
BCM: Bcenmc03_1650
BCJ: BCAL1729(cobK)
BAM: Bamb_1577(cbiJ)
BAC: BamMC406_1595
BMU: Bmul_1565
BMJ: BMULJ_01679(cobK)
BXE: Bxe_B1248(cobK)
BPH: Bphy_3140
BPY: Bphyt_5366
BGL: bglu_1g18410
DAC: Daci_5847
CTT: CtCNB1_1873
GLO: Glov_3647
PCA: Pcar_0470(cobK)
MLO: mll1382(cobK)
SME: SMc03189(cobK)
SMD: Smed_2814(cbiJ)
ATU: Atu2799(cobK)
ATC: AGR_C_5078
ARA: Arad_9592(cobK)
AVI: Avi_2628(cobK)
RET: RHE_PE00451(cobK)
REC: RHECIAT_PA0000374(cobK)
RLE: pRL110627(cobK)
RLT: Rleg2_6023
RLG: Rleg_7178
RHI: NGR_c29770(cobK)
BME: BMEI0702(cobK)
BMF: BAB1_1319(cobK)
BMB: BruAb1_1300(cobK)
BMC: BAbS19_I12320
BMS: BR1299(cobK)
BMT: BSUIS_A1349(cobK)
BOV: BOV_1263(cobK)
BCS: BCAN_A1322(cobK)
BMR: BMI_I1312(cobK)
OAN: Oant_1886
BJA: bll3268(cobK)
BRA: BRADO4902(cobK)
BBT: BBta_3149(cobK)
RPA: RPA2087(cobK)
RPB: RPB_3181(cobK)
RPC: RPC_1885(cobK)
RPD: RPD_2317(cbiJ)
RPE: RPE_2222(cobK)
RPT: Rpal_2377
XAU: Xaut_3281
AZC: AZC_3941(cobK)
MEX: Mext_4722
MEA: Mex_1p5173(cobK)
MDI: METDI5775(cobK)
MRD: Mrad2831_3120
MET: M446_2443
MPO: Mpop_5261
MCH: Mchl_5189 Mchl_5688
MNO: Mnod_2154
BID: Bind_3512
MSL: Msil_3263
SIL: SPO2868(cobK)
SIT: TM1040_2215
RSP: RSP_2825(cobK)
RSH: Rsph17029_1472(cbiJ)
RSQ: Rsph17025_1522(cobK)
RSK: RSKD131_1139
JAN: Jann_2926
RDE: RD1_3177(cobK) RD1_3822(cobK)
PDE: Pden_2537
DSH: Dshi_1690(cobK)
NAR: Saro_0337
APT: APA01_14520
RRU: Rru_A2988
MAG: amb2641
GKA: GK1803
GTN: GTNG_1692(cbiJ)
GWC: GWCH70_1552
GYC: GYMC61_2614
AFL: Aflv_2178
LMO: lmo1200
LMF: LMOf2365_1209(cobK)
LMH: LMHCC_1451(cbiJ)
LMC: Lm4b_01204
LIN: lin1163
LWE: lwe1157(cbiJ)
LSP: Bsph_3444
BBE: BBR47_12470(cbiJ)
SSA: SSA_0473
LRE: Lreu_1713
LRF: LAR_1601
CAC: CAC1381(cbiJ)
CPE: CPE1219(cbiJ)
CPF: CPF_1427(cobK)
CPR: CPR_1233(cobK)
CTC: CTC00740(cobK)
CNO: NT01CX_0574(cobK)
CDF: CD3423(cbiJ)
CDC: CD196_3199(cbiJ)
CDL: CDR20291_3245(cbiJ)
CBO: CBO0950(cbiJ)
CBA: CLB_0992(cobK)
CBH: CLC_1006(cobK)
CBY: CLM_1101(cobK)
CBL: CLK_0388(cobK)
CBK: CLL_A2929(cobK)
CBB: CLD_3610(cobK)
CBI: CLJ_B1000(cobK)
CBT: CLH_2675(cobK)
CBF: CLI_1039(cobK)
CBE: Cbei_1258(cbiJ)
CKL: CKL_0729(cbiJ)
CKR: CKR_0651
AMT: Amet_0077
AOE: Clos_1022
VPR: Vpar_1140
DSY: DSY4065(cobK)
DHD: Dhaf_1301
DRM: Dred_2708
DAE: Dtox_1297 Dtox_2748
PTH: PTH_0956
HMO: HM1_2392(cbiJ)
EEL: EUBELI_20182
TEX: Teth514_0316
CHY: CHY_0765(cobK)
MTA: Moth_1095 Moth_1223
ADG: Adeg_0937
NTH: Nther_0936
MTU: Rv2070c(cobK)
MTC: MT2130(cobK)
MRA: MRA_2084(cobK)
MTF: TBFG_12106(cobK)
MTB: TBMG_01911(TBMG_01911.1)
MBO: Mb2096c(cobK)
MBB: BCG_2089c(cobK)
MBT: JTY_2083(cobK)
MPA: MAP1815c(cobK)
MAV: MAV_2427(cobK)
MSM: MSMEG_3875(cobK)
MUL: MUL_2296(cobK)
MVA: Mvan_0378
MGI: Mflv_0359
MAB: MAB_2197
MMC: Mmcs_2485(cobK)
MKM: Mkms_2530(cobK)
MJL: Mjls_2522(cbiJ)
MMI: MMAR_3052(cobK)
CDI: DIP1234(cobK)
CKP: ckrop_0902(cobK)
NFA: nfa31540(cobK)
RHA: RHA1_ro00826(cobK)
RER: RER_31580(cobK)
ROP: ROP_05640(cobK)
GBR: Gbro_2478
SCO: SCO3283(cbiJ)
SMA: SAV_1601(cobK)
SGR: SGR_3821
PAC: PPA0440(cobK)
NCA: Noca_2881
TFU: Tfu_0310
SRO: Sros_5596
FRA: Francci3_1522(cobK)
FRE: Franean1_5478
FAL: FRAAL2334(cobK)
NML: Namu_0176
SEN: SACE_5950(cobK)
SVI: Svir_17710
AMI: Amir_1780
CAI: Caci_6989
SHI: Shel_21200
TDE: TDE0624
CPI: Cpin_4478
FNU: FN0950
LBA: Lebu_0268
STR: Sterm_1028
SYN: slr0252(cobK)
SYW: SYNW1776
SYC: syc1476_d(cobK)
SYF: Synpcc7942_0021
SYD: Syncc9605_0688
SYE: Syncc9902_1670
SYG: sync_2025(cobK)
SYR: SynRCC307_0882(cobK)
SYX: SynWH7803_0618(cobK)
CYA: CYA_2390(cobK)
CYB: CYB_0118(cobK)
TEL: tlr1056(cobK)
MAR: MAE_37180(cbiJ)
CYT: cce_1635(cbiJ)
CYP: PCC8801_4032
CYC: PCC7424_0523
CYN: Cyan7425_5134
CYH: Cyan8802_4070
ANA: all1780(cbiJ)
NPU: Npun_R4791
AVA: Ava_0256(cobK)
PMA: Pro0503(cobK)
PMM: PMM0503
PMT: PMT1264
PMN: PMN2A_1836
PMI: PMT9312_0504
PMB: A9601_05601(cobK)
PMC: P9515_05671(cobK)
PMF: P9303_07381(cobK)
PMG: P9301_05301(cobK)
PMH: P9215_05851(cobK)
PMJ: P9211_05031 P9211_05041
PME: NATL1_05611(cobK)
TER: Tery_2739(cobK)
AMR: AM1_2859(cobK)
PAA: Paes_1287
CTS: Ctha_2214
DGE: Dgeo_2355
TME: Tmel_0705
TAF: THA_1075(cobK)
MJA: MJ0552
MFE: Mefer_0798
MVU: Metvu_0734
MMP: MMP0599(cbiJ)
MMQ: MmarC5_1007
MMX: MmarC6_0293
MMZ: MmarC7_1621
MAE: Maeo_0220
MVN: Mevan_1471
MTH: MTH1002
MST: Msp_1205(cbiJ)
MSI: Msm_0896
PTO: PTO0039 PTO0112
Taxonomy
Reference
  Authors
  Title


  Journal
  Organism
 1  [PMID:1732193]
Blanche F, Thibaut D, Famechon A, Debussche L, Cameron B, Crouzet J.
Precorrin-6x reductase from Pseudomonas denitrificans: purification
and characterization of the enzyme and identification of the
structural gene.
J. Bacteriol. 174 (1992) 1036-42.
Pseudomonas denitrificans
Reference
  Authors
  Title
  Journal
  Organism
 2  [PMID:12195810]
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC.
The biosynthesis of adenosylcobalamin (vitamin B12).
Nat. Prod. Rep. 19 (2002) 390-412.
Propionibacterium freundenreichii
Other DBs ExplorEnz - The Enzyme Database: 1.3.1.54
IUBMB Enzyme Nomenclature: 1.3.1.54
ExPASy - ENZYME nomenclature database: 1.3.1.54
BRENDA, the Enzyme Database: 1.3.1.54
CAS: 137573-72-9
DBGET integrated database retrieval system