| Entry |
|
|---|
| Name |
Delta24(241)-sterol reductase;
sterol Delta24(28)-methylene reductase;
sterol Delta24(28)-reductase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
ergosterol:NADP+ Delta24(241)-oxidoreductase |
|---|
| Reaction(IUBMB) |
ergosterol + NADP+ = ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH
+ H+ [RN:R05641] |
|---|
| Reaction(KEGG) |
R05641
 |
|---|
| Substrate |
ergosterol [CPD:C01694];
NADP+ [CPD:C00006] |
|---|
| Product |
ergosta-5,7,22,24(241)-tetraen-3beta-ol;
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Comment |
Acts on a range of steroids with a 24(241)-double bond. |
|---|
| Pathway |
PATH: ec00100 Steroid biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00223 delta24(24(1))-sterol reductase |
|---|
| Genes |
SCE: YGL012W(ERG4)
AGO: AGOS_AGL087C
KLA: KLLA0A05071g
DHA: DEHA0A08888g
PIC: PICST_29811
CAL: CaO19.12834(ERG4) CaO19.5379(ERG4)
CGR: CAGL0A00429g
YLI: YALI0D19206g
SPO: SPAC20G4.07c(erg4)
NCR: NCU01333
ANI: AN5184.2
AOR: AO090012000966
CNE: CNC04470
UMA: UM01498.1
TCR: 506577.120 507709.90
LMA: LmjF33.0680
CBU: CBU_1206
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:14922]
Neal WD, Parks LW.
Sterol 24(28) methylene reductase in Saccharomyces cerevisiae.
J. Bacteriol. 129 (1977) 1375-8.
Saccharomyces cerevisiae [GN:sce] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:10722850]
Zweytick D, Hrastnik C, Kohlwein SD, Daum G.
Biochemical characterization and subcellular localization of the
sterol C-24(28) reductase, erg4p, from the yeast saccharomyces
cerevisiae.
FEBS. Lett. 470 (2000) 83-7.
Saccharomyces cerevisiae [GN:sce] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.3.1.71
IUBMB Enzyme Nomenclature: 1.3.1.71
ExPASy - ENZYME nomenclature database: 1.3.1.71
BRENDA, the Enzyme Database: 1.3.1.71 |
|---|
