| Entry |
|
|---|
| Name |
Delta24-sterol reductase;
lanosterol Delta24-reductase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
sterol:NADP+ Delta24-oxidoreductase |
|---|
| Reaction(IUBMB) |
5alpha-cholest-7-en-3beta-ol + NADP+ =
5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H+ [RN:R05703] |
|---|
| Reaction(KEGG) |
R05703;
(other) R01457 R03689 R07488 R07493 R07498 R07499 R07507
 |
|---|
| Substrate |
5alpha-cholest-7-en-3beta-ol [CPD:C01189];
NADP+ [CPD:C00006] |
|---|
| Product |
5alpha-cholesta-7,24-dien-3beta-ol [CPD:C05439];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Comment |
Acts on a range of steroids with a 24(25)-double bond, including
lanosterol, desmosterol and zymosterol. |
|---|
| Pathway |
PATH: ec00100 Steroid biosynthesis
PATH: ec01062 Biosynthesis of terpenoids and steroids
PATH: ec01066 Biosynthesis of alkaloids derived from terpenoid and
polyketide
PATH: ec01070 Biosynthesis of plant hormones
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K09828 delta24-sterol reductase |
|---|
| Genes |
HSA: 1718(DHCR24)
PTR: 456879(DHCR24)
MCC: 717022
MMU: 74754(Dhcr24)
RNO: 298298(Dhcr24)
CFA: 489573(DHCR24)
BTA: 533726(DHCR24)
ECB: 100034055(DHCR24)
OAA: 100088141
GGA: 424661(DHCR24)
TGU: 100220338
XLA: 444688
XTR: 549554(dhcr24)
DRE: 494102(dhcr24)
SPU: 587262
ATH: AT3G19820(DWF1)
MGR: MGG_06580
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:9291139]
Bae SH, Paik YK.
Cholesterol biosynthesis from lanosterol: development of a novel
assay method and characterization of rat liver microsomal lanosterol
delta 24-reductase.
Biochem. J. 326 ( Pt 2) (1997) 609-16.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.3.1.72
IUBMB Enzyme Nomenclature: 1.3.1.72
ExPASy - ENZYME nomenclature database: 1.3.1.72
BRENDA, the Enzyme Database: 1.3.1.72
CAS: 9033-57-2 |
|---|
