| Entry |
|
|---|
| Name |
anthocyanidin reductase;
AtANR;
MtANR |
|---|
| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
flavan-3-ol:NAD(P)+ oxidoreductase |
|---|
| Reaction(IUBMB) |
a flavan-3-ol + 2 NAD(P)+ = an anthocyanidin + 2 NAD(P)H + H+
[RN:R07351 R07352] |
|---|
| Reaction(KEGG) |
R07352 > R06541 R06542 R06543;
R07351
 |
|---|
| Substrate |
flavan-3-ol;
NAD+ [CPD:C00003];
NADP+ [CPD:C00006] |
|---|
| Product |
anthocyanidin [CPD:C02003];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Comment |
Forms 2,3-cis-flavan-3-ols. The isomeric 2,3-trans-flavan-3-ols are
formed from flavan-3,4-diols by EC 1.17.1.3 leucoanthocyanidin
reductase. While the enzyme from the legume Medicago truncatula
(MtANR) uses both NADPH and NADH as reductant, that from the
crucifer Arabidopsis thaliana (AtANR) uses only NADPH. Also, while
the substrate preference of MtANR is
cyanidin>pelargonidin>delphinidin, the reverse preference is found
with AtANR. |
|---|
| Pathway |
PATH: ec00941 Flavonoid biosynthesis
PATH: ec01061 Biosynthesis of phenylpropanoids |
|---|
| Orthology |
KO: K08695 anthocyanidin reductase |
|---|
| Genes |
ATH: AT1G61720(BAN)
OSA: 4337100(Os04g0630800)
 |
|---|
| Structures |
PDB: 2RH8 3HFS |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:12532018]
Xie DY, Sharma SB, Paiva NL, Ferreira D, Dixon RA.
Role of anthocyanidin reductase, encoded by BANYULS in plant
flavonoid biosynthesis.
Science. 299 (2003) 396-9.
Arabidopsis thaliana [GN:ath], Medicago truncatula |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:14725861]
Xie DY, Sharma SB, Dixon RA.
Anthocyanidin reductases from Medicago truncatula and Arabidopsis
thaliana.
Arch. Biochem. Biophys. 422 (2004) 91-102.
Arabidopsis thaliana [GN:ath], Medicago truncatula |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.3.1.77
IUBMB Enzyme Nomenclature: 1.3.1.77
ExPASy - ENZYME nomenclature database: 1.3.1.77
BRENDA, the Enzyme Database: 1.3.1.77
CAS: 93389-48-1 |
|---|
