KEGG   ENZYME: 1.3.1.77Help
Entry
EC 1.3.1.77                 Enzyme                                 

Name
anthocyanidin reductase;
AtANR;
MtANR
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
flavan-3-ol:NAD(P)+ oxidoreductase
Reaction(IUBMB)
a flavan-3-ol + 2 NAD(P)+ = an anthocyanidin + 2 NAD(P)H + H+ [RN:R07351 R07352]
Reaction(KEGG)
Substrate
flavan-3-ol [CPD:C15598];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
anthocyanidin [CPD:C02003];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Forms 2,3-cis-flavan-3-ols. The isomeric 2,3-trans-flavan-3-ols are formed from flavan-3,4-diols by EC 1.17.1.3 leucoanthocyanidin reductase. While the enzyme from the legume Medicago truncatula (MtANR) uses both NADPH and NADH as reductant, that from the crucifer Arabidopsis thaliana (AtANR) uses only NADPH. Also, while the substrate preference of MtANR is cyanidin>pelargonidin>delphinidin, the reverse preference is found with AtANR.
History
EC 1.3.1.77 created 2004
Pathway
Flavonoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K08695  
anthocyanidin reductase
Genes
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
CAM: 
FVE: 
PPER: 
RCU: 
POP: 
POPTR_0004s03030g(POPTRDRAFT_831060) POPTR_0011s03430g(POPTRDRAFT_834000)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os04t0630300-01(Os04g0630300) Os04t0630400-01(Os04g0630400) Os04t0630600-00(Os04g0630600) Os04t0630800-01(Os04g0630800) Os04t0631000-00(Os04g0631000)
OBR: 
BDI: 
SBI: 
SORBI_06g029520(SORBIDRAFT_06g029520) SORBI_06g029550(SORBIDRAFT_06g029550) SORBI_06g029560(SORBIDRAFT_06g029560) SORBI_06g029570(SORBIDRAFT_06g029570) SORBI_06g029580(SORBIDRAFT_06g029580) SORBI_06g029590(SORBIDRAFT_06g029590) SORBI_06g029600(SORBIDRAFT_06g029600) SORBI_06g029610(SORBIDRAFT_06g029610) SORBI_06g029620(SORBIDRAFT_06g029620) SORBI_06g029630(SORBIDRAFT_06g029630)
ZMA: 
SITA: 
ATR: 
s00098p00115100(AMTR_s00098p00115100)
 » show all
Taxonomy
Reference
1  [PMID:12532018]
  Authors
Xie DY, Sharma SB, Paiva NL, Ferreira D, Dixon RA.
  Title
Role of anthocyanidin reductase, encoded by BANYULS in plant flavonoid biosynthesis.
  Journal
Science. 299 (2003) 396-9.
  Organism
Arabidopsis thaliana, Medicago truncatula
  Sequence
[ath:AT1G61720]
Reference
2  [PMID:14725861]
  Authors
Xie DY, Sharma SB, Dixon RA.
  Title
Anthocyanidin reductases from Medicago truncatula and Arabidopsis thaliana.
  Journal
Arch. Biochem. Biophys. 422 (2004) 91-102.
  Organism
Arabidopsis thaliana, Medicago truncatula
  Sequence
[ath:AT1G61720]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
93389-48-1

DBGET integrated database retrieval system