| Entry |
|
|---|
| Name |
coproporphyrinogen oxidase;
coproporphyrinogen III oxidase;
coproporphyrinogenase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With oxygen as acceptor
 |
|---|
| Sysname |
coproporphyrinogen:oxygen oxidoreductase (decarboxylating) |
|---|
| Reaction(IUBMB) |
coproporphyrinogen III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 +
2 H2O [RN:R03220] |
|---|
| Reaction(KEGG) |
R03220
 |
|---|
| Substrate |
coproporphyrinogen III [CPD:C03263];
O2 [CPD:C00007];
H+ [CPD:C00080] |
|---|
| Product |
protoporphyrinogen IX [CPD:C01079];
CO2 [CPD:C00011];
H2O [CPD:C00001] |
|---|
| Pathway |
PATH: ec00860 Porphyrin and chlorophyll metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00228 coproporphyrinogen III oxidase |
|---|
| Genes |
HSA: 1371(CPOX)
PTR: 460544(CPOX)
MCC: 698849(CPOX)
MMU: 12892(Cpox)
RNO: 304024(Cpox)
CFA: 487948
BTA: 540283(CPOX)
ECB: 100072394
MDO: 100031341
OAA: 100089783
GGA: 418377(CPOX)
TGU: 100221663
DRE: 321294(cpox)
CIN: 100177681
SPU: 580851
DME: Dmel_CG3433(Coprox)
DPO: Dpse_GA17449
DAN: Dana_GF15439
DER: Dere_GG10448
DPE: Dper_GL26198
DSE: Dsec_GM16261
DSI: Dsim_GD23442
DYA: Dyak_GE14253
DGR: Dgri_GH13345
DMO: Dmoj_GI17730
AGA: AgaP_AGAP004749
AAG: AaeL_AAEL013389
CQU: CpipJ_CPIJ006245
AME: 552084
NVI: 100119936
TCA: 656916
API: 100160677
ISC: IscW_ISCW010977
SMM: Smp_162280
NVE: NEMVE_v1g149268 NEMVE_v1g229388
HMG: 100213358
TAD: TRIADDRAFT_25736
ATH: AT1G03475(LIN2)
POP: POPTR_771064
RCU: RCOM_0902640
VVI: 100243271
OSA: 4336951(Os04g0610800)
SBI: SORBI_06g028140(SORBIDRAFT_06g028140)
PPP: PHYPADRAFT_109483 PHYPADRAFT_224363
CRE: CHLREDRAFT_53583(CPX1)
OLU: OSTLU_30642
CME: CMO136C
SCE: YDR044W(HEM13)
AGO: AGOS_AGR030C
KLA: KLLA0F18546g
LTH: KLTH0C07194g
DHA: DEHA0F17798g
PIC: PICST_64368(HEM13)
PPA: PAS_chr3_0943
VPO: Kpol_1052p17
LEL: LELG_02000
ZRO: ZYRO0C13552g
CTP: CTRG_02611
CDU: CD36_83990
CGR: CAGL0K12100g
YLI: YALI0E29975g
SPO: SPAC222.11(hem13)
NCR: NCU01546
PAN: PODANSg6354
MGR: MGG_01061
FGR: FG10739.1
ANI: AN5130.2
AFM: AFUA_1G07480
AOR: AO090012000998
ANG: An07g10040
AFV: AFLA_022410
PCS: Pc12g05380
NFI: NFIA_017270
CIM: CIMG_02510
URE: UREG_03208
SSL: SS1G_01603
BFU: BC1G_02466
CNE: CNE00980
CNB: CNBE0930
LBC: LACBIDRAFT_159108
MPR: MPER_06868
UMA: UM02317.1
MGL: MGL_1247
MBR: MONBRDRAFT_28565
DDI: DDB_0231414(hemF)
PFA: PF11_0436
PFD: PFDG_03673
PFH: PFHG_03524
PYO: PY05501
PBE: PB000335.03.0
PKN: PKH_093980
PVX: PVX_092725
TGO: TGME49_023020
TET: TTHERM_00716050
PTM: GSPATT00007017001 GSPATT00016653001
LMA: LmjF06.1270
LIF: LinJ06.1320
LBZ: LbrM06_V2.1260
PTI: PHATRDRAFT_15068(HemF_1) PHATR_10640(HemF_2)
TPS: THAPSDRAFT_31012(Cpx1)
ECO: b2436(hemF)
ECJ: JW2429(hemF)
ECD: ECDH10B_2601(hemF)
EBW: BWG_2198(hemF)
ECE: Z3701(hemF)
ECS: ECs3307
ECF: ECH74115_3666(hemF)
ETW: ECSP_3383(hemF)
ECG: E2348C_2620(hemF)
ECC: c2970(hemF)
ECI: UTI89_C2769(hemF)
ECP: ECP_2457
ECV: APECO1_4112(hemF)
ECW: EcE24377A_2722(hemF)
ECX: EcHS_A2573(hemF)
ECM: EcSMS35_2591(hemF)
ECY: ECSE_2726
ECL: EcolC_1243
ECK: EC55989_2725(hemF)
ECQ: ECED1_2878(hemF)
ECR: ECIAI1_2493(hemF)
ECT: ECIAI39_2581(hemF)
ECZ: ECS88_2624(hemF)
EUM: ECUMN_2757(hemF)
ELF: LF82_0980(hemF)
EBL: B21_02298(hemF)
EBD: ECBD_1246
EBR: ECB_02336(hemF)
EOH: ECO103_2954(hemF)
EOI: ECO111_3165(hemF)
EOJ: ECO26_3488(hemF)
EFE: EFER_0736(hemF)
STY: STY2688(hemF)
STT: t0407(hemF)
SPT: SPA0415(hemF)
SEK: SSPA0389
SPQ: SPAB_00503
SEI: SPC_1207(hemF)
SEC: SC2450(hemF)
SEH: SeHA_C2711(hemF)
SEE: SNSL254_A2645(hemF)
SEW: SeSA_A2687(hemF)
SEA: SeAg_B2596(hemF)
SED: SeD_A2817(hemF)
SEG: SG2483(hemF)
SET: SEN2432(hemF)
SES: SARI_00431
STM: STM2451(hemF)
YPE: YPO3032(hemF)
YPK: y1451(hemF)
YPM: YP_2655(hemF)
YPA: YPA_2220
YPN: YPN_1353
YPG: YpAngola_A2784(hemF)
YPP: YPDSF_2137
YPS: YPTB2754(hemF)
YPI: YpsIP31758_1280(hemF)
YPY: YPK_1393
YPB: YPTS_2856
YEN: YE1168(hemF)
SFL: SF2489(hemF)
SFV: SFV_2488(hemF)
SSN: SSON_2525(hemF)
SBO: SBO_2461(hemF)
SBC: SbBS512_E2808(hemF)
SDY: SDY_2634(hemF)
ECA: ECA0874(hemF)
PCT: PC1_0757
PWA: Pecwa_0993
ETA: ETA_10850(hemF)
PLU: plu1383(hemF)
PAY: PAU_01393(hemF)
WBR: WGLp584(hemF)
SGL: SG1712
ENT: Ent638_2957
ESA: ESA_00813
CTU: Ctu_30290(hemF)
KPN: KPN_02779(hemF)
KPE: KPK_1358(hemF)
KPU: KP1_4029(hemF)
CKO: CKO_00350
SPE: Spro_3464
PMR: PMI1839(hemF)
EIC: NT01EI_1236
ETR: ETAE_1125
HDE: HDEF_1258(hemF)
DDA: Dd703_3211
DDC: Dd586_0781
DZE: Dd1591_3290
XFA: XF0017
XFT: PD0015(hemF)
XFM: Xfasm12_0017
XFN: XfasM23_0015
XCC: XCC4019(hemF)
XCB: XC_4108
XCA: xccb100_4212
XCV: XCV4198(hemF)
XAC: XAC4109(hemF)
XOO: XOO4239(hemF)
XOM: XOO_4002
XOP: PXO_03935(hemF)
SML: Smlt4586(hemF)
SMT: Smal_3938
VCH: VC0055
VCO: VC0395_A2465(hemF)
VCM: VCM66_0055(hemF)
VCJ: VCD_001523
VVU: VV1_1056
VVY: VV3216
VPA: VP3034
VHA: VIBHAR_00383
VSP: VS_3118
VEX: VEA_002066
VFI: VF_A0558
VFM: VFMJ11_A0571
VSA: VSAL_II0652
PPR: PBPRA3572
PAE: PA0024(hemF)
PAU: PA14_00280(hemF)
PAP: PSPA7_0025(hemF)
PAG: PLES_00231(hemF)
PPU: PP_0073(hemF)
PPF: Pput_0089
PPG: PputGB1_0089
PPW: PputW619_0092
PST: PSPTO_0170(hemF)
PSB: Psyr_0024
PSP: PSPPH_0026(hemF)
PFL: PFL_0027(hemF)
PFO: Pfl01_0022
PFS: PFLU0023(hemF)
PEN: PSEEN0030(hemF)
PMY: Pmen_0060
PSA: PST_0026(hemF)
CJA: CJA_3587(hemF)
AVN: Avin_00220
PAR: Psyc_0219(hemF)
PCR: Pcryo_0243
PRW: PsycPRwf_0409
ACI: ACIAD3250(hemF)
ACB: A1S_3108
ABM: ABSDF0387(hemF)
ABY: ABAYE0378(hemF)
ABC: ACICU_03309
ABN: AB57_3560(hemF)
ABB: ABBFA_000403
SON: SO_0038(hemF)
SDN: Sden_0030
SFR: Sfri_0030
SAZ: Sama_0050
SBL: Sbal_0038
SBM: Shew185_0033
SBN: Sbal195_0037
SBP: Sbal223_0037
SLO: Shew_3729
SPC: Sputcn32_0030
SSE: Ssed_0042
SPL: Spea_0038
SHE: Shewmr4_0035
SHM: Shewmr7_0033
SHN: Shewana3_0041
SHW: Sputw3181_0030
SHL: Shal_0034
SWD: Swoo_0045
SWP: swp_0064
ILO: IL0023(hemF)
CPS: CPS_3996(hemF)
PHA: PSHAa0029(hemF)
PAT: Patl_0029
SDE: Sde_0025
MAQ: Maqu_0047
AMC: MADE_00028
PIN: Ping_2246
TTU: TERTU_0042(hemF)
CBU: CBU_1729(hemF)
CBS: COXBURSA331_A1921(hemF)
CBD: CBUD_0273(hemF)
CBG: CbuG_0110(hemF)
CBC: CbuK_0278(hemF)
LPN: lpg1215(hemF)
LPF: lpl1223(hemF)
LPP: lpp1223(hemF)
LPC: LPC_0684(hemF)
MCA: MCA2791(hemF)
FTU: FTT_1063(hemF)
FTF: FTF1063(hemF)
FTW: FTW_0975(hemF)
FTL: FTL_1022
FTH: FTH_0997(hemF)
FTA: FTA_1078(hemF)
FTM: FTM_0889(hemF)
FTN: FTN_0953(hemF)
FPH: Fphi_1842
TCX: Tcr_0017
NOC: Noc_2824
AEH: Mlg_2634
HHA: Hhal_2320
TGR: Tgr7_0116
HNA: Hneap_2092
HCH: HCH_00036(hemF)
CSA: Csal_2863
ABO: ABO_0135 ABO_1342(hemF) ABO_2580
MMW: Mmwyl1_0061
AHA: AHA_0265(hemF)
ASA: ASA_4133(hemF)
AFE: Lferr_1910
AFR: AFE_2263(hemF)
RMA: Rmag_0496
VOK: COSY_0456(hemF)
KKO: Kkor_2611
CVI: CV_0757(hemF)
LHK: LHK_00717(hem6)
RSO: RSc2192(hemF)
RPI: Rpic_2390
RPF: Rpic12D_1990
REU: Reut_A2524
REH: H16_A0914(hemF)
RME: Rmet_0783
CTI: RALTA_A0857(hemF)
BMA: BMA1886(hemF)
BMV: BMASAVP1_A1073(hemF)
BML: BMA10229_A0794(hemF)
BMN: BMA10247_0356(hemF)
BPS: BPSL1163(hemF)
BPM: BURPS1710b_1383(hemF)
BPL: BURPS1106A_1238(hemF)
BPD: BURPS668_1229(hemF)
BPR: GBP346_A1255(hemF)
BTE: BTH_I1013(hemF)
BVI: Bcep1808_2381
BUR: Bcep18194_A5623
BCN: Bcen_1684
BCH: Bcen2424_2296
BCM: Bcenmc03_2319
BCJ: BCAL2390(hemF)
BAM: Bamb_2334
BAC: BamMC406_2213
BMU: Bmul_0982
BMJ: BMULJ_02282(hemF)
BXE: Bxe_A3261
BPH: Bphy_2066
BPY: Bphyt_1299
BGL: bglu_1g26370
PNU: Pnuc_0616
PNE: Pnec_1239
BPE: BP2310(hemF)
BPA: BPP2420(hemF)
BBR: BB1869(hemF)
BPT: Bpet3101(hemF)
BAV: BAV2209(hemF)
RFR: Rfer_2077
POL: Bpro_1970
PNA: Pnap_1730
AAV: Aave_3201
AJS: Ajs_1900
VEI: Veis_4240
DAC: Daci_3523
DIA: Dtpsy_1705
VAP: Vapar_2685
CTT: CtCNB1_2897
MPT: Mpe_A1339
HAR: HEAR0556(hemF)
MMS: mma_0542(hemF)
LCH: Lcho_1951
NEU: NE1876(hemF)
NET: Neut_1956
NMU: Nmul_A0135
EBA: ebA1156(hemF)
AZO: azo2896(hemF) azo3965
DAR: Daro_3669
TMZ: Tmz1t_1441
TBD: Tbd_2461
MFA: Mfla_0346
MMB: Mmol_0401
MEI: Msip34_0378
APP: CAP2UW1_0795
ADE: Adeh_2014
ACP: A2cp1_1949
AFW: Anae109_1703
ANK: AnaeK_1864
MXA: MXAN_6762(hemF)
HOH: Hoch_2765
RPR: RP882
RTY: RT0874(hemF)
RCM: A1E_05660
RCO: RC1369(hemF)
RFE: RF_1396(hemF)
RAK: A1C_06860
RRI: A1G_07495
RRJ: RrIowa_1598
RMS: RMA_1385(hemF)
RPK: RPR_07740
RAF: RAF_ORF1254(hemF)
RBE: RBE_1380(hemF)
RBO: A1I_07665
OTS: OTBS_0188(hemF)
OTT: OTT_1778(hemF)
WOL: WD1214
WBM: Wbm0709
WRI: WRi_011940
WPI: WPa_0965
AMA: AM762(hemF)
AMF: AMF_564(hemF)
ACN: ACIS_00567(hemF)
APH: APH_0423(hemF)
ERU: Erum4550(hemF)
ERW: ERWE_CDS_04770(hemF)
ERG: ERGA_CDS_04670(hemF)
ECN: Ecaj_0446
ECH: ECH_0591(hemF)
NSE: NSE_0454(hemF)
NRI: NRI_0429(hemF)
PUB: SAR11_0102(hemF)
MLO: mlr2722
MES: Meso_2169
PLA: Plav_2240
SME: SMc00180(hemF)
SMD: Smed_1549
ATU: Atu2247(hemF)
ATC: AGR_C_4089(hemF)
ARA: Arad_3212(hemF)
AVI: Avi_3221(hemF)
RET: RHE_CH03046(hemF)
REC: RHECIAT_CH0003206(hemF)
RLE: RL3494(hemF)
RLT: Rleg2_2786
RLG: Rleg_3050
LAS: CLIBASIA_04875
BME: BMEI0467
BMF: BAB1_1566(hemF)
BMB: BruAb1_1539(hemF)
BMC: BAbS19_I14640
BMS: BR1550(hemF)
BMT: BSUIS_A1608
BOV: BOV_1498(hemF)
BCS: BCAN_A1586
BMR: BMI_I1564(hemF)
OAN: Oant_1616
BJA: bll2481(hemF)
BRA: BRADO1972(hemF)
BBT: BBta_2296(hemF)
RPA: RPA1514(hemF)
RPB: RPB_4009
RPC: RPC_1263
RPD: RPD_3764
RPE: RPE_1317
RPT: Rpal_1701
NWI: Nwi_2621
NHA: Nham_3246
OCA: OCAR_7000(hemF)
XAU: Xaut_2954
AZC: AZC_3503
MEX: Mext_0673
MEA: Mex_1p0498(hemF)
MDI: METDI0653(hemF)
MRD: Mrad2831_4671
MET: M446_6063
MPO: Mpop_0647
MCH: Mchl_0684
MNO: Mnod_6599
BID: Bind_0060
MSL: Msil_3804
CCR: CC_0506
CCS: CCNA_00540
CAK: Caul_0699
PZU: PHZ_c2874(hemF)
SIL: SPO3653(hemF)
SIT: TM1040_2531
RSP: RSP_0682(hemF) RSP_3816
RSH: Rsph17029_2337
RSQ: Rsph17025_0548
RSK: RSKD131_2040
JAN: Jann_3848
RDE: RD1_1282(hemF)
PDE: Pden_1752
DSH: Dshi_0674(hemF)
MMR: Mmar10_0734
HNE: HNE_0349(hemF)
HBA: Hbal_0740
ZMO: ZMO0951
ZMN: Za10_0349
NAR: Saro_2536
SAL: Sala_1347
SWI: Swit_1398
ELI: ELI_09420
GOX: GOX1896
GBE: GbCGDNIH1_1722
ACR: Acry_2944
GDI: GDI_2058(hemF)
GDJ: Gdia_0279
APT: APA01_08060
RCE: RC1_3420(hemF)
LLM: llmg_1418(hemN)
PCU: pc1975(hemF)
LIL: LB017(hemF)
LIC: LIC20015(hemN)
LBJ: LBJ_4015(hemN)
LBL: LBL_4015(hemN)
SRU: SRU_1742(hemF)
RMR: Rmar_1193
CHU: CHU_1918(hemF)
DFE: Dfer_2369
CPI: Cpin_6503
PHE: Phep_2162
GFO: GFO_1414(hemN) GFO_3228(hemF)
FJO: Fjoh_0950
FPS: FP0037(hemF)
RBI: RB2501_06000
OTE: Oter_2696
GAU: GAU_1136(hemF)
SYN: sll1185(hemF)
SYW: SYNW2040(hemF)
SYC: syc0855_c(hemF)
SYF: Synpcc7942_0674
SYD: Syncc9605_0403
SYE: Syncc9902_1926
SYG: sync_0467(hemF)
SYR: SynRCC307_2083(hemF)
SYX: SynWH7803_0461(hemF)
SYP: SYNPCC7002_A1828(hemF)
CYA: CYA_0869(hemF)
CYB: CYB_2837(hemF)
TEL: tll0684(hemF)
MAR: MAE_06700(hemF)
CYT: cce_3201(hemF)
CYP: PCC8801_1148
CYC: PCC7424_3053
CYN: Cyan7425_1891
CYH: Cyan8802_1178
GVI: gvip515(hemF)
ANA: all0650(hemF) all1357
NPU: Npun_F5168
AVA: Ava_4581 Ava_4996
PMA: Pro1737(hemF)
PMM: PMM1582(hemF)
PMT: PMT1706(hemF)
PMN: PMN2A_1154
PMI: PMT9312_1674
PMB: A9601_15101(hemN) A9601_17891(hemF)
PMC: P9515_14721(hemN) P9515_17691(hemF)
PMF: P9303_22671(hemF)
PMG: P9301_14971(hemN) P9301_17731(hemF)
PMH: P9215_18541(hemF)
PMJ: P9211_17021(hemF)
PME: NATL1_20281(hemF)
TER: Tery_1166
AMR: AM1_0615(hemF)
CAU: Caur_2599
CAG: Cagg_1294
CHL: Chy400_2808
 |
|---|
| Structures |
PDB: 1TK1 1TKL 1TLB 1TXN 1VJU 2AEX 2QT8 3DWR 3DWS 3E8J
3EJO |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:5881662]
del Batlle AM, Benson A, Rimington C.
Purification and properties of coproporphyrinogenase.
Biochem. J. 97 (1965) 731-40.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:8955072]
Medlock AE, Dailey HA.
Human coproporphyrinogen oxidase is not a metalloprotein.
J. Biol. Chem. 271 (1996) 32507-10.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:8407975]
Kohno H, Furukawa T, Yoshinaga T, Tokunaga R, Taketani S.
Coproporphyrinogen oxidase. Purification, molecular cloning, and
induction of mRNA during erythroid differentiation.
J. Biol. Chem. 268 (1993) 21359-63.
Bos taurus [GN:bta] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.3.3.3
IUBMB Enzyme Nomenclature: 1.3.3.3
ExPASy - ENZYME nomenclature database: 1.3.3.3
BRENDA, the Enzyme Database: 1.3.3.3
CAS: 9076-84-0 |
|---|
