| Entry |
|
|---|
| Name |
acyl-CoA oxidase;
fatty acyl-CoA oxidase;
acyl coenzyme A oxidase;
fatty acyl-coenzyme A oxidase |
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| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With oxygen as acceptor
 |
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| Sysname |
acyl-CoA:oxygen 2-oxidoreductase |
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| Reaction(IUBMB) |
acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2 [RN:R00388] |
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| Reaction(KEGG) |
R00388;
(other) R01175 R01279 R03777 R03857 R03990 R04751 R04754 R07888
R07892 R07896 R07934 R07950
 |
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| Substrate |
acyl-CoA [CPD:C00040];
O2 [CPD:C00007] |
|---|
| Product |
trans-2,3-dehydroacyl-CoA [CPD:C00658];
H2O2 [CPD:C00027] |
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| Cofactor |
FAD [CPD:C00016] |
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| Comment |
A flavoprotein (FAD). Acts on CoA derivatives of fatty acids with
chain lengths from 8 to 18. |
|---|
| Pathway |
PATH: ec00071 Fatty acid metabolism
PATH: ec00592 alpha-Linolenic acid metabolism
PATH: ec01040 Biosynthesis of unsaturated fatty acids
PATH: ec01070 Biosynthesis of plant hormones
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K00232 acyl-CoA oxidase |
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| Genes |
HSA: 51(ACOX1) 8310(ACOX3)
PTR: 454895(ACOX1) 461115(ACOX3)
MCC: 705197(ACOX1) 722634(ACOX3)
MMU: 11430(Acox1) 80911(Acox3)
RNO: 50681(Acox1) 83522(Acox3)
CFA: 483322(ACOX1) 488790(ACOX3)
BTA: 510065(ACOX3) 513996(ACOX1)
SSC: 100113422(ACOX1)
ECB: 100051466(ACOX1) 100056690
MDO: 100019995 100022432
OAA: 100083493
GGA: 417366(ACOX1) 422869(ACOX3)
TGU: 100224774 100230333
XLA: 403357 735228
XTR: 548479
DRE: 406421(acox3) 449662(acox1)
BFO: BRAFLDRAFT_219230
CIN: 100181154 100181361 100186673
SPU: 578168 580036 580903
DME: Dmel_CG17544 Dmel_CG4586 Dmel_CG5009 Dmel_CG9527
Dmel_CG9707(Acox57D-p) Dmel_CG9709(Acox57D-d)
DPO: Dpse_GA14550 Dpse_GA18591 Dpse_GA21857 Dpse_GA21980
Dpse_GA21981
DAN: Dana_GF11673 Dana_GF12814 Dana_GF12816 Dana_GF15197
Dana_GF15389
DER: Dere_GG21636 Dere_GG21822 Dere_GG22112 Dere_GG22113
Dere_GG23624
DPE: Dper_GL11770 Dper_GL11771 Dper_GL17222 Dper_GL21109
Dper_GL26258
DSE: Dsec_GM15834 Dsec_GM15835 Dsec_GM17014 Dsec_GM17941
Dsec_GM21823
DSI: Dsim_GD11316 Dsim_GD11593 Dsim_GD11595 Dsim_GD21764
Dsim_GD22578
DYA: Dyak_GE11899 Dyak_GE12194 Dyak_GE12195 Dyak_GE12655
Dyak_GE18444
DGR: Dgri_GH10984 Dgri_GH13470 Dgri_GH21827 Dgri_GH21832
Dgri_GH22025
DMO: Dmoj_GI17222 Dmoj_GI17496 Dmoj_GI19074 Dmoj_GI19075
Dmoj_GI19114
AGA: AgaP_AGAP007958 AgaP_AGAP008016 AgaP_AGAP011798
AAG: AaeL_AAEL000370 AaeL_AAEL008574 AaeL_AAEL008841
CQU: CpipJ_CPIJ001556 CpipJ_CPIJ003870 CpipJ_CPIJ006187
AME: 412020 552757
NVI: 100115159 100119298 100122596(Acox3)
TCA: 658001 660385 662475
API: 100159207 100163509
ISC: IscW_ISCW013214 IscW_ISCW017262
CEL: C48B4.1 F08A8.1 F08A8.2 F08A8.3 F08A8.4 F25C8.1 F58F9.7 F59F4.1
CBR: CBG05491 CBG05550 CBG10043 CBG16008
BMY: Bm1_15615
NVE: NEMVE_v1g235541 NEMVE_v1g237514
HMG: 100202148 100214840
TAD: TRIADDRAFT_18987 TRIADDRAFT_28074 TRIADDRAFT_38001
ATH: AT1G06290(ACX3) AT1G06310(ACX6) AT2G35690(ACX5) AT3G51840(ACX4)
AT4G16760(ACX1) AT5G65110(ACX2)
POP: POPTR_582787 POPTR_735866 POPTR_831370 POPTR_832274
POPTR_836303
RCU: RCOM_0186930 RCOM_0554440 RCOM_1119640
VVI: 100249305 100255430(GSVIVT00005192001)
100257524(GSVIVT00018681001)
OSA: 4324062(Os01g0159400) 4339846(Os06g0103500)
4340986(Os06g0354500) 4350881(Os11g0605500)
SBI: SORBI_03g039670(SORBIDRAFT_03g039670)
SORBI_10g004260(SORBIDRAFT_10g004260)
ZMA: 100191469 100283936(cl716_1) 100285661
PPP: PHYPADRAFT_102649 PHYPADRAFT_159691 PHYPADRAFT_207164
PHYPADRAFT_217871 PHYPADRAFT_221246 PHYPADRAFT_231834
CRE: CHLREDRAFT_121379 CHLREDRAFT_122887 CHLREDRAFT_170822
OLU: OSTLU_13743
CME: CMK115C
SCE: YGL205W(POX1)
AGO: AGOS_AER358C
KLA: KLLA0F09933g
LTH: KLTH0G01914g
DHA: DEHA0C01155g DEHA0D18722g
PIC: PICST_75424(POX1)
PPA: PAS_chr1-4_0538
VPO: Kpol_1035p54
LEL: LELG_02931
ZRO: ZYRO0E08338g
CAL: CaO19.1652(POX104)
CTP: CTRG_02377 CTRG_02721
CDU: CD36_64100 CD36_81950(POX1)
CGR: CAGL0A03740g
YLI: YALI0C23859g YALI0D24750g YALI0F10857g
FGR: FG02287.1
ANI: AN6752.2
AFM: AFUA_7G06090 AFUA_7G06100
AOR: AO090005000479 AO090010000014
AFV: AFLA_077250 AFLA_115890
PCS: Pc20g01800
NFI: NFIA_027340
CIM: CIMG_07097
URE: UREG_01105 UREG_05801
SSL: SS1G_10238
BFU: BC1G_08482
CNE: CNG00320
CNB: CNBG4450
LBC: LACBIDRAFT_319093
MPR: MPER_03508
UMA: UM02208.1 UM04324.1
MGL: MGL_4209
MBR: MONBRDRAFT_29702
DDI: DDB_0234154 DDB_0234155
TGO: TGME49_047500
TET: TTHERM_00079730 TTHERM_00242260 TTHERM_00370760 TTHERM_00586710
PTM: GSPATT00009871001 GSPATT00012079001
PTI: PHATRDRAFT_19979(AOX1)
TPS: THAPSDRAFT_263878(AOX1_1)
PLU: plu2336
PAY: PAU_02326(aco)
PPW: PputW619_4651
PFS: PFLU3198
MXA: MXAN_6432
MPA: MAP2101
MAV: MAV_2078
MSM: MSMEG_4474
MUL: MUL_1233
MVA: Mvan_3808
MGI: Mflv_2726
MAB: MAB_3588
MMC: Mmcs_3435
MKM: Mkms_3498
MJL: Mjls_3446
MMI: MMAR_3631
CJK: jk1941(acx)
CUR: cur_1845
CAR: cauri_2169(acx)
NFA: nfa24790
RHA: RHA1_ro02047
RER: RER_16630
ROP: ROP_17180
GBR: Gbro_1022
SGR: SGR_6404 SGR_6637
LXX: Lxx21820(acx2)
CMI: CMM_0813
CMS: CMS_0070
ART: Arth_2142
AAU: AAur_2138
ACH: Achl_1889
RSA: RSal33209_2074
KRH: KRH_16780
MLU: Mlut_11700
BCV: Bcav_3568
BFA: Bfae_23500
JDE: Jden_2376
KSE: Ksed_21270
XCE: Xcel_3111
NCA: Noca_0437
TFU: Tfu_2239
KRA: Krad_4030
SEN: SACE_5537 SACE_7372
SVI: Svir_31740
CAI: Caci_3363
SRU: SRU_1701
FJO: Fjoh_3394
RBI: RB2501_03675
 |
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| Structures |
PDB: 1IS2 1W07 2DDH 2FON 2IX5 2IX6 |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:7462191]
Kawaguchi A, Tsubotani S, Seyama Y, Yamakawa T, Osumi T, Hashimoto
T, Kikuchi T, Ando M, Okuda S.
Stereochemistry of dehydrogenation catalyzed by Acyl-CoA oxidase.
J. Biochem. (Tokyo). 88 (1980) 1481-6.
Rattus norvegicus [GN:rno], Candida lipolytica |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:7400120]
Osumi T, Hashimoto T, Ui N.
Purification and properties of acyl-CoA oxidase from rat liver.
J. Biochem. (Tokyo). 87 (1980) 1735-46.
Rattus norvegicus [GN:rno] |
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| Other DBs |
ExplorEnz - The Enzyme Database: 1.3.3.6
IUBMB Enzyme Nomenclature: 1.3.3.6
ExPASy - ENZYME nomenclature database: 1.3.3.6
BRENDA, the Enzyme Database: 1.3.3.6
CAS: 61116-22-1 |
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