KEGG   ENZYME: 1.3.5.1Help
Entry
EC 1.3.5.1                  Enzyme                                 
Name
succinate dehydrogenase (ubiquinone);
succinic dehydrogenase;
complex II;
menaquinol: fumarate oxidoreductase;
fumarate reductase complex (i.e. FRD, involved in anaerobic respiration, repressed in aerobic respiration);
succinate dehydrogenase complex (i. e. SDH, involved in aerobic respiration, repressed in anaerobic respiration)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a quinone or related compound as acceptor
BRITE hierarchy
Sysname
succinate:ubiquinone oxidoreductase
Reaction(IUBMB)
succinate + ubiquinone = fumarate + ubiquinol [RN:R02164]
Reaction(KEGG)
Substrate
succinate [CPD:C00042];
ubiquinone [CPD:C00399]
Product
fumarate [CPD:C00122];
ubiquinol [CPD:C00390]
Comment
A flavoprotein (FAD) containing iron-sulfur centres. The complex, present in mitochondria, can be degraded to form EC 1.3.99.1 succinate dehydrogenase, which no longer reacts with ubiquinone.
Pathway
Citrate cycle (TCA cycle)
Oxidative phosphorylation
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K00234  
succinate dehydrogenase (ubiquinone) flavoprotein subunit
K00235  
succinate dehydrogenase (ubiquinone) iron-sulfur subunit
Genes
HSA: 
6389(SDHA) 6390(SDHB)
PTR: 
100608629 456526(SDHB) 750143(SDHA)
PPS: 
100987473(SDHA) 100989574(SDHB)
GGO: 
101131972(SDHB) 101141874(SDHA)
PON: 
100173631(SDHA) 100437700(SDHB)
MCC: 
MMU: 
66945(Sdha) 67680(Sdhb)
RNO: 
157074(Sdha) 298596(Sdhb)
CFA: 
478217(SDHB) 478634(SDHA)
AML: 
FCA: 
751617(SDHB) 751619(SDHA)
BTA: 
281480(SDHA) 286840(SDHB)
SSC: 
414412(SDHB) 780433(SDHA)
ECB: 
100034244(SDHA) 100050091(SDHB)
MDO: 
751078(SDHB) 751085(SDHA)
SHR: 
100924299(SDHB) 100931806(SDHA)
OAA: 
100074487 100083131
GGA: 
100859720 395758(SDHA) 770063(SDHB)
MGP: 
100543850 100546340
TGU: 
100190642(SDHB) 100230079
ACS: 
100551545 100556555
XLA: 
379939(sdhb) 380463(sdha) 398946(MGC68518)
XTR: 
100144957(sdhb) 548743(sdha)
DRE: 
393884(sdha) 562149(sdhb)
TRU: 
101072453 101075255 101076572
OLA: 
101169635 101171309
BFO: 
BRAFLDRAFT_128477 BRAFLDRAFT_273662
CIN: 
100181830 100183000
SPU: 
580610 589263
DME: 
Dmel_CG17246(SdhA) Dmel_CG3283(SdhB) Dmel_CG5718 Dmel_CG7349
DPO: 
Dpse_GA14410 Dpse_GA17170 Dpse_GA19081 Dpse_GA20284
DAN: 
Dana_GF11072 Dana_GF12611 Dana_GF19050 Dana_GF24501
DER: 
Dere_GG13871 Dere_GG19200 Dere_GG20911 Dere_GG23224
DPE: 
Dper_GL11120 Dper_GL11254 Dper_GL21331 Dper_GL25074
DSE: 
Dsec_GM19835 Dsec_GM20899 Dsec_GM22932 Dsec_GM24693
DSI: 
Dsim_GD10425 Dsim_GD12763 Dsim_GD17417 Dsim_GD25325
DWI: 
Dwil_GK22142 Dwil_GK22213 Dwil_GK25101
DYA: 
Dyak_GE13850 Dyak_GE17763 Dyak_GE19076 Dyak_GE20163
DGR: 
Dgri_GH10931 Dgri_GH16714 Dgri_GH21756 Dgri_GH22974
DMO: 
Dmoj_GI14882 Dmoj_GI18459 Dmoj_GI19303
DVI: 
Dvir_GJ11663 Dvir_GJ15311 Dvir_GJ21546 Dvir_GJ22180
AGA: 
AgaP_AGAP007309 AgaP_AGAP010429
AAG: 
AaeL_AAEL010330 AaeL_AAEL010608
CQU: 
CpipJ_CPIJ006167 CpipJ_CPIJ017679
AME: 
550667(SdhA) 551169
NVI: 
100116862(SdhB) 100119074(Sdha)
TCA: 
657039 658066(SdhB)
API: 
100162363(Sdhb) 100166540
PHU: 
Phum_PHUM530140 Phum_PHUM612230
ISC: 
IscW_ISCW000555 IscW_ISCW018067
CEL: 
CELE_C03G5.1(sdha-1) CELE_C34B2.7(sdha-2) CELE_F42A8.2(sdhb-1)
CBR: 
CBG00872(Cbr-sdhb-1) CBG12805(Cbr-sdha-2) CBG22795(Cbr-sdha-1)
BMY: 
Bm1_17330 Bm1_17690
TSP: 
Tsp_06974 Tsp_09576
SMM: 
Smp_061230 Smp_089640.2
NVE: 
NEMVE_v1g113343 NEMVE_v1g181975
HMG: 
100206520 100210215
TAD: 
TRIADDRAFT_38520 TRIADDRAFT_63313
AQU: 
100632409
ATH: 
AT2G18450(SDH1-2) AT3G27380(SDH2-1) AT5G40650(SDH2-2) AT5G65165(SDH2-3) AT5G66760(SDH1-1)
ALY: 
ARALYDRAFT_332733(SDH2-3) ARALYDRAFT_480752(SDH1-2) ARALYDRAFT_493917(SDH2-2) ARALYDRAFT_496924(SDH1-1) ARALYDRAFT_904976(SDH2-1)
GMX: 
100796630 100802169 100815377 100818379
MTR: 
MTR_5g020050
CSV: 
101209955 101211616 101220767 101231415
RCU: 
RCOM_0325190 RCOM_0530950 RCOM_0566460
POP: 
POPTR_219180 POPTR_593943 POPTR_815545
VVI: 
100244487 100254718 100262907
OSA: 
4342350 4344541 4346890
DOSA: 
Os07t0134800-01(Os07g0134800) Os08t0120000-01(Os08g0120000) Os09t0370300-01(Os09g0370300)
BDI: 
100823502 100831380 100839755 100841750
SBI: 
SORBI_01g006490(SORBIDRAFT_01g006490) SORBI_02g023310(SORBIDRAFT_02g023310)
ZMA: 
100216648(csu474(rpS14)) 100279930(TIDP3457) 100280324 100502233
SMO: 
SELMODRAFT_440964 SELMODRAFT_446158 SELMODRAFT_57580 SELMODRAFT_82638
PPP: 
PHYPADRAFT_181904 PHYPADRAFT_196863 PHYPADRAFT_5986
CRE: 
CHLREDRAFT_142231(SDH2) CHLREDRAFT_195972(SDH1)
VCN: 
VOLCADRAFT_74298(sdh1) VOLCADRAFT_78776(sdh2)
OLU: 
OSTLU_29304 OSTLU_43363
OTA: 
Ot14g00120 Ot15g00650
CME: 
CMT582C
SCE: 
YJL045W YKL148C(SDH1) YLL041C(SDH2)
AGO: 
AGOS_ACL065C AGOS_ACR052W
ERC: 
Ecym_8248 Ecym_8411
KLA: 
KLLA0D04444g KLLA0E00683g
LTH: 
KLTH0E05742g KLTH0G07480g
PPA: 
PAS_chr3_1111 PAS_chr4_0733
VPO: 
Kpol_1070p4 Kpol_388p3 Kpol_543p66
ZRO: 
ZYRO0C10736g ZYRO0G07788g
CGR: 
CAGL0C03223g CAGL0E03850g CAGL0J00847g
NCS: 
NCAS_0C05870(NCAS0C05870) NCAS_0F02320(NCAS0F02320)
NDI: 
NDAI_0C03810(NDAI0C03810) NDAI_0H00250(NDAI0H00250)
TPF: 
TPHA_0E02930(TPHA0E02930) TPHA_0F00210(TPHA0F00210)
TBL: 
TBLA_0A10080(TBLA0A10080) TBLA_0E01400(TBLA0E01400)
TDL: 
TDEL_0E03730(TDEL0E03730) TDEL_0G01780(TDEL0G01780)
KAF: 
KAFR_0H03590(KAFR0H03590) KAFR_0L00230(KAFR0L00230)
DHA: 
DEHA2E07458g DEHA2G19382g
PIC: 
PICST_50416(SDH2) PICST_66251(SDH1)
PGU: 
PGUG_03289 PGUG_05465
LEL: 
LELG_01770 LELG_03274 LELG_05728
CAL: 
CaO19.10389 CaO19.2871(SDH1) CaO19.440(SDH1) CaO19.637(SDH2) CaO19.8070 CaO19.8251(SDH2)
CTP: 
CTRG_00535 CTRG_03795 CTRG_04515
CDU: 
CD36_05000 CD36_30410 CD36_46090
COT: 
CORT_0B01340 CORT_0B09040 CORT_0D04680
YLI: 
YALI0D11374g YALI0D23397g
CLU: 
CLUG_00494 CLUG_04005
NCR: 
NCU00959 NCU08336
SMP: 
SMAC_00236 SMAC_01605
PAN: 
PODANSg5587 PODANSg5625
TTT: 
THITE_2122016 THITE_61645
MTM: 
MYCTH_2294679 MYCTH_2295190
MGR: 
MGG_00167 MGG_00168
FGR: 
FG05610.1 FG07361.1
NHE: 
NECHADRAFT_68374 NECHADRAFT_95465
VAL: 
VDBG_04666 VDBG_04895
SSL: 
SS1G_04384 SS1G_07864
BFU: 
BC1G_07795 BC1G_13286
ANI: 
AN2332.2 AN2916.2
NFI: 
NFIA_069350 NFIA_076860
AFM: 
AFUA_3G07810 AFUA_5G10370
AOR: 
AOR_1_730084(AO090020000415) AOR_1_838024(AO090010000505)
ANG: 
ANI_1_1750024(An02g12770) ANI_1_2706024(An02g07600)
AFV: 
AFLA_099990 AFLA_119870
ACT: 
ACLA_013460 ACLA_035740
PCS: 
Pc20g06030 Pc21g09900
CIM: 
CIMG_02339 CIMG_05754 CIMG_06614
CPW: 
CPC735_024240 CPC735_030760 CPC735_039850
PBL: 
PAAG_01725 PAAG_04238 PAAG_06103
URE: 
UREG_01411 UREG_03831 UREG_04544
ABE: 
ARB_02933 ARB_06591
TVE: 
TRV_04812 TRV_07643
AJE: 
HCAG_03263 HCAG_06317
PNO: 
SNOG_03351 SNOG_16547
PTE: 
PTT_03506 PTT_14436 PTT_15756
ZTR: 
MYCGRDRAFT_53658(SDH1) MYCGRDRAFT_71498 MYCGRDRAFT_74146(SDH2)
TML: 
GSTUM_00002676001 GSTUM_00009772001
SPO: 
SPAC140.01(sdh2) SPAC1556.02c(sdh1)
CNE: 
CNG03480 CNI03270
CNB: 
CNBG1290 CNBH3130
CGI: 
CGB_G1600C CGB_H4700C
LBC: 
LACBIDRAFT_182791 LACBIDRAFT_188373 LACBIDRAFT_247971
MPR: 
MPER_11995
CCI: 
CC1G_06084 CC1G_09250
SCM: 
SCHCODRAFT_66862 SCHCODRAFT_74617
UMA: 
UM00844.1 UM01172.1
MGL: 
MGL_3104 MGL_3463
PGR: 
PGTG_10848
MBR: 
MONBRDRAFT_33413 MONBRDRAFT_33571
NGR: 
NAEGRDRAFT_83231
DDI: 
DDB_G0270120(sdhB) DDB_G0280535(sdhA)
DPP: 
DICPUDRAFT_48520
PFA: 
PF10_0334 PFL0630w
PFD: 
PFDG_02621 PFDG_04097
PFH: 
PFHG_01332 PFHG_02795
PYO: 
PY04921 PY05468
PCB: 
PC000220.05.0 PC001322.02.0
PBE: 
PB000191.02.0 PB300700.00.0
PKN: 
PKH_061930 PKH_143010
PVX: 
PVX_111005 PVX_123345
PCY: 
PCYB_062870 PCYB_143960
TAN: 
TA03455 TA19430
TPV: 
TP01_0210 TP03_0230
BBO: 
BBOV_IV005280(23.m06368) BBOV_IV007210(23.m06369)
TGO: 
TGME49_015280 TGME49_015590
TET: 
TTHERM_00047080 TTHERM_00241700
PTM: 
GSPATT00008605001 GSPATT00018337001 GSPATT00032079001 GSPATT00035998001 PTMB.181
TBR: 
Tb927.8.6580(Tb08.30K1.380)
TCR: 
506399.89 511909.40
LMA: 
LMJF_24_1630
LIF: 
LINJ_24_1700
LDO: 
LDBPK_241700
LMI: 
LMXM_24_1630
LBZ: 
LBRM_15_1030 LBRM_24_1690
PTI: 
PHATRDRAFT_52539(SDH2) PHATR_41812(SDH1)
TPS: 
THAPSDRAFT_32945(SDH1) THAPSDRAFT_42475
PIF: 
PITG_10951 PITG_18354
 » show all
Taxonomy
Reference
1
  Authors
Hatefi, Y., Ragan, C.I. and Galante, Y.M.
  Title
The enzymes and the enzyme complexes of the mitochondrial oxidative phosphorylation system.
  Journal
In: Martonosi, A. (Ed.), The Enzymes of Biological Membranes, 2nd ed., vol. 4, Plenum Press, New York, 1985, p. 1-70.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-11-9
DBGET integrated database retrieval system