KEGG   ENZYME: 1.3.7.9Help
Entry
EC 1.3.7.9                  Enzyme                                 

Name
4-hydroxybenzoyl-CoA reductase;
4-hydroxybenzoyl-CoA reductase (dehydroxylating);
4-hydroxybenzoyl-CoA:(acceptor) oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
benzoyl-CoA:acceptor oxidoreductase
Reaction(IUBMB)
benzoyl-CoA + oxidized ferredoxin + H2O = 4-hydroxybenzoyl-CoA + reduced ferredoxin [RN:R05316]
Reaction(KEGG)
Substrate
benzoyl-CoA [CPD:C00512];
oxidized ferredoxin [CPD:C00139];
H2O [CPD:C00001]
Product
4-hydroxybenzoyl-CoA [CPD:C02949];
reduced ferredoxin [CPD:C00138]
Comment
A molybdenum-flavin-iron-sulfur protein that is involved in the anaerobic pathway of phenol metabolism in bacteria. A ferredoxin with two [4Fe-4S] clusters functions as the natural electron donor [3].
History
EC 1.3.7.9 created 2000 as EC 1.3.99.20, transferred 2011 to EC 1.3.7.9
Pathway
Benzoate degradation
Aminobenzoate degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K04107  
4-hydroxybenzoyl-CoA reductase subunit gamma
K04108  
4-hydroxybenzoyl-CoA reductase subunit alpha
K04109  
4-hydroxybenzoyl-CoA reductase subunit beta
Genes
EBA: 
ebA3602(hcrB) ebA3603(hcrA) ebA3604(hcrC)
TMZ: 
GEO: 
GEM: 
RPA: 
RPA0670(hbaB) RPA0671(hbaC) RPA0672(hbaD)
RPC: 
RPD: 
RPE: 
RPT: 
RPX: 
MAG: 
 » show all
Taxonomy
Reference
1  [PMID:2753161]
  Authors
Glockler R, Tschech A, Fuchs G.
  Title
Reductive dehydroxylation of 4-hydroxybenzoyl-CoA to benzoyl-CoA in a denitrifying, phenol-degrading Pseudomonas species.
  Journal
FEBS. Lett. 251 (1989) 237-40.
  Organism
Pseudomonas sp.
Reference
2  [PMID:9683649]
  Authors
Heider J, Boll M, Breese K, Breinig S, Ebenau-Jehle C, Feil U, Gad'on N, Laempe D, Leuthner B, Mohamed ME, Schneider S, Burchhardt G, Fuchs G.
  Title
Differential induction of enzymes involved in anaerobic metabolism of aromatic compounds in the denitrifying bacterium Thauera aromatica.
  Journal
Arch. Microbiol. 170 (1998) 120-31.
  Organism
Thauera aromatica
Reference
3  [PMID:9490068]
  Authors
Breese K, Fuchs G.
  Title
4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from the denitrifying bacterium Thauera aromatica--prosthetic groups, electron donor, and genes of a member of the molybdenum-flavin-iron-sulfur proteins.
  Journal
Eur. J. Biochem. 251 (1998) 916-23.
  Organism
Thauera aromatica
  Sequence
[tmz:Tmz1t_0225 Tmz1t_0226 Tmz1t_0224] (Thauera sp.)
Reference
4  [PMID:8477729]
  Authors
Brackmann R, Fuchs G.
  Title
Enzymes of anaerobic metabolism of phenolic compounds. 4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from a denitrifying Pseudomonas species.
  Journal
Eur. J. Biochem. 213 (1993) 563-71.
  Organism
Pseudomonas sp.
Reference
5  [PMID:9057820]
  Authors
Heider J, Fuchs G.
  Title
Anaerobic metabolism of aromatic compounds.
  Journal
Eur. J. Biochem. 243 (1997) 577-96.
  Organism
Azoarcus evansii, Rhodopseudonmonas palustris, Thauera aromatica
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
133758-58-4

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