| Entry |
|
|---|
| Name |
isovaleryl-CoA dehydrogenase;
isovaleryl-coenzyme A dehydrogenase;
isovaleroyl-coenzyme A dehydrogenase;
3-methylbutanoyl-CoA:(acceptor) oxidoreductase |
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| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With other acceptors
 |
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| Sysname |
3-methylbutanoyl-CoA:acceptor oxidoreductase |
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| Reaction(IUBMB) |
3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced
acceptor [RN:R04096] |
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| Reaction(KEGG) |
R04096 > R04095
 |
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| Substrate |
3-methylbutanoyl-CoA [CPD:C02939];
acceptor [CPD:C00028] |
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| Product |
3-methylbut-2-enoyl-CoA [CPD:C03069];
reduced acceptor [CPD:C00030] |
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| Cofactor |
FAD [CPD:C00016] |
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| Comment |
A flavoprotein; forms with electron-transferring flavoprotein and EC
1.5.5.1 electron-transferring-flavoprotein dehydrogenase, a system
reducing ubiquinone. n-Pentanoate can act as donor. Not identical
with EC 1.3.99.2 (butyryl-CoA dehydrogenase), EC 1.3.99.3 (acyl-CoA
dehydrogenase) or EC 1.3.99.12 (2-methylacyl-CoA dehydrogenase). |
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| Pathway |
PATH: ec00280 Valine, leucine and isoleucine degradation |
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| Orthology |
KO: K00253 isovaleryl-CoA dehydrogenase |
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| Genes |
HSA: 3712(IVD)
PTR: 453333(IVD)
MCC: 702867(IVD)
MMU: 56357(Ivd)
RNO: 24513(Ivd)
CFA: 478259(IVD)
BTA: 510440(IVD)
SSC: 100156047(IVD)
ECB: 100057233
MDO: 100031931
OAA: 100090657
GGA: 423011(IVD)
TGU: 100221014
XTR: 496848(ivd)
DRE: 368775(ivd)
SPU: 591888
DME: Dmel_CG6638
DPO: Dpse_GA19744
AGA: AgaP_AGAP006780
AAG: AaeL_AAEL003125
AME: 408288
CEL: C02B10.1(ivd-1)
CBR: CBG19978
NVE: NEMVE_v1g194219
TAD: TRIADDRAFT_27663
ATH: AT3G45300(IVD)
OSA: 4337676(Os05g0125500)
PPP: PHYPADRAFT_146390
CRE: CHLREDRAFT_128289
CME: CMT072C
YLI: YALI0E12573g
NCR: NCU02126
PAN: PODANSg4507
MGR: MGCH7_ch7g256 MGG_02540
FGR: FG08510.1
ANI: AN4688.2
AFM: AFUA_5G08930
AOR: AO090020000493
ANG: An07g04280
NFI: NFIA_078380
BFU: BC1G_08865
CNE: CNA04330
CNB: CNBA4160
LBC: LACBIDRAFT_182156(IVD)
UMA: UM04833.1
MBR: MONBRDRAFT_32617
DDI: DDB_0230189(ivdA)
TET: TTHERM_01019590
PTM: GSPATT00014131001
TBR: Tb11.55.0026
TCR: 506629.220
LMA: LmjF27.0930
XCC: XCC0246(acdA)
XCB: XC_0256
XCA: xccb100_0268(ivd)
XCV: XCV0273(acdA)
XAC: XAC0265(acdA)
XOO: XOO4379(acdA)
XOM: XOO_4123
XOP: PXO_03805
SML: Smlt0239
SMT: Smal_0198
VVU: VV2_0496
VVY: VVA1046
VPA: VPA0618 VPA1125
VHA: VIBHAR_05480
PPR: PBPRB1114
PAE: PA2015(liuA)
PAU: PA14_38440(gnyD)
PAP: PSPA7_3274
PPU: PP_4064(ivd)
PPF: Pput_1777
PPG: PputGB1_3662
PPW: PputW619_1812
PST: PSPTO_2739
PSB: Psyr_2470
PFL: PFL_3936(ivd)
PFO: Pfl01_3656
PEN: PSEEN3386(ivd)
PMY: Pmen_2033
PSA: PST_3213
PAR: Psyc_0313(acd)
PCR: Pcryo_0344
PRW: PsycPRwf_2062
ACB: A1S_1376
ABY: ABAYE2288
ABC: ACICU_01411
ABN: AB57_1601
ABB: ABBFA_002118
SON: SO_1897(ivd)
SDN: Sden_2245
SFR: Sfri_2727
SAZ: Sama_1362
SBL: Sbal_2828
SBM: Shew185_2846
SBN: Sbal195_2973
SLO: Shew_2570
SPC: Sputcn32_1719
SSE: Ssed_1458
SPL: Spea_2797
SHE: Shewmr4_2322
SHM: Shewmr7_2394
SHN: Shewana3_1672
SHW: Sputw3181_2306
SHL: Shal_2902
SWD: Swoo_3223
SWP: swp_3442
ILO: IL0874
CPS: CPS_1603(ivd)
PHA: PSHAa0906 PSHAa1452
PAT: Patl_2925
MAQ: Maqu_2121
AMC: MADE_02412
CBU: CBU_0973
CBS: COXBURSA331_A0966
CBD: CBUD_1074
CBG: CbuG_1032
CBC: CbuK_0866
LPN: lpg1824
LPF: lpl1788
LPP: lpp1787
LPC: LPC_1268
HCH: HCH_03943
ABO: ABO_1240(ivd)
AHA: AHA_2078
ASA: ASA_1912(ivd)
CVI: CV_1766
RSO: RSc0279
RPI: Rpic_0129
REU: Reut_A0135 Reut_A1466
REH: H16_A0167(ivd1) H16_A1291 H16_A1972(ivd2)
RME: Rmet_0103
CTI: RALTA_A0110
BMA: BMAA0802(ivd)
BMV: BMASAVP1_0542(ivd)
BML: BMA10229_0654(ivd)
BMN: BMA10247_A1608(ivd)
BPS: BPSS1448
BPM: BURPS1710b_A0471
BPL: BURPS1106A_A1959
BPD: BURPS668_A2056
BTE: BTH_II0947
BVI: Bcep1808_3495
BUR: Bcep18194_A4473 Bcep18194_A4816 Bcep18194_A5469 Bcep18194_A5559
Bcep18194_A5560 Bcep18194_A6219 Bcep18194_A6220 Bcep18194_B0423
Bcep18194_B1437 Bcep18194_B1441 Bcep18194_B2484 Bcep18194_C7127
Bcep18194_C7145 Bcep18194_C7146 Bcep18194_C7297 Bcep18194_C7499
Bcep18194_C7558 Bcep18194_C7712
BCN: Bcen_3127
BCH: Bcen2424_5240
BCM: Bcenmc03_5032
BCJ: BCAM2433
BAM: Bamb_2269 Bamb_2270 Bamb_2932 Bamb_2933 Bamb_4588
BAC: BamMC406_5121
BMU: Bmul_3466
BMJ: BMULJ_05050(ivd)
BXE: Bxe_B0960
BPH: Bphy_3562
BPY: Bphyt_4686
BPA: BPP4359(ivd)
BBR: BB4945(ivd)
BPT: Bpet0059(ivd)
BAV: BAV3369(ivd)
RFR: Rfer_3842
POL: Bpro_4190
PNA: Pnap_0455
AAV: Aave_4371
AJS: Ajs_0118 Ajs_3779
VEI: Veis_1333 Veis_2500
DAC: Daci_5991
MPT: Mpe_A3360
LCH: Lcho_2119
EBA: ebA4656(acd)
AZO: azo3081
DAR: Daro_0100
APP: CAP2UW1_4335
GME: Gmet_3289
BBA: Bd1201
SCL: sce9239
SFU: Sfum_1260
MLO: mll7732
MES: Meso_0931
PLA: Plav_2780
SME: SM_b21121(ivdH)
SMD: Smed_4532
ATU: Atu3477(acd)
ATC: AGR_L_2707
RET: RHE_PC00064(ivdH)
RLE: pRL100296(ivdH)
RLT: Rleg2_4378
BME: BMEI1923
BMB: BruAb1_0020(ivd)
BMC: BAbS19_I00170
BMS: BR0020(ivd)
BMT: BSUIS_A0021
BOV: BOV_0017(ivd)
BCS: BCAN_A0020
BMR: BMI_I20(ivd)
OAN: Oant_0037
BJA: blr4419(acd)
BRA: BRADO0920 BRADO1442 BRADO1447(ivd2) BRADO3035
BBT: BBta_6658(ivd2) BBta_6663 BBta_7132
RPA: RPA1614(ivd2)
RPB: RPB_3933
RPC: RPC_4263
RPD: RPD_0356 RPD_3693
RPE: RPE_4310
RPT: Rpal_1804
NWI: Nwi_3018
NHA: Nham_3387
XAU: Xaut_4272
AZC: AZC_2833
MET: M446_2318
CCR: CC_2172
CCS: CCNA_02254
CAK: Caul_3157
PZU: PHZ_c1284(ivd)
SIL: SPO2793(ivd)
SIT: TM1040_0732 TM1040_2444
RSP: RSP_2506(ivdH)
RSH: Rsph17029_1168
RSQ: Rsph17025_2013
JAN: Jann_1142
RDE: RD1_3301(ivd)
PDE: Pden_3633
DSH: Dshi_1297(ivd)
MMR: Mmar10_1739
HNE: HNE_1272(ivd2)
NAR: Saro_1645
SAL: Sala_1529
SWI: Swit_2161
ELI: ELI_11785
ACR: Acry_2188
RRU: Rru_A1948 Rru_A3064
RCE: RC1_0401(ivd2)
MAG: amb0677
MJL: Mjls_4147 Mjls_4228
RHA: RHA1_ro11032
FAL: FRAAL2513 FRAAL3418 FRAAL4873 FRAAL6459
LIL: LA0414
LIC: LIC10363(ivd)
LBJ: LBJ_2429(ivd)
LBL: LBL_0682(ivd)
LBI: LEPBI_I1138
LBF: LBF_1096(ivd)
TAC: Ta0230
TVO: TVN1269
PTO: PTO1189
 |
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| Structures |
PDB: 1IVH |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:13319276]
BACHHAWAT BK, ROBINSON WG, COON MJ.
Enzymatic carboxylation of beta-hydroxyisovaleryl coenzyme A.
J. Biol. Chem. 219 (1956) 539-50.
Rattus norvegicus [GN:rno], Sus scofa [GN:ssc] |
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Reference
Authors
Title
Journal
Organism
|
2 [PMID:6401713]
Ikeda Y, Tanaka K.
Purification and characterization of isovaleryl coenzyme A
dehydrogenase from rat liver mitochondria.
J. Biol. Chem. 258 (1983) 1077-85.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:5229850]
Tanaka K, Budd MA, Efron ML, Isselbacher KJ.
Isovaleric acidemia: a new genetic defect of leucine metabolism.
Proc. Natl. Acad. Sci. U. S. A. 56 (1966) 236-42.
Homo sapiens [GN:hsa] |
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| Other DBs |
ExplorEnz - The Enzyme Database: 1.3.99.10
IUBMB Enzyme Nomenclature: 1.3.99.10
ExPASy - ENZYME nomenclature database: 1.3.99.10
BRENDA, the Enzyme Database: 1.3.99.10
CAS: 37274-61-6 |
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