| Entry |
|
|---|
| Name |
2-methylacyl-CoA dehydrogenase;
branched-chain acyl-CoA dehydrogenase;
2-methyl branched chain acyl-CoA dehydrogenase;
2-methylbutanoyl-CoA:(acceptor) oxidoreductase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With other acceptors
 |
|---|
| Sysname |
2-methylbutanoyl-CoA:acceptor oxidoreductase |
|---|
| Reaction(IUBMB) |
2-methylbutanoyl-CoA + acceptor = 2-methylbut-2-enoyl-CoA + reduced
acceptor [RN:R03173] |
|---|
| Reaction(KEGG) |
R03173 > R03172;
(other) R02661
 |
|---|
| Substrate |
2-methylbutanoyl-CoA [CPD:C01033];
acceptor [CPD:C00028] |
|---|
| Product |
2-methylbut-2-enoyl-CoA [CPD:C03345];
reduced acceptor [CPD:C00030] |
|---|
| Comment |
Also oxidizes 2-methylpropanoyl-CoA. Not identical with EC 1.3.99.2
(butyryl-CoA dehydrogenase), EC 1.3.99.3 (acyl-CoA dehydrogenase),
EC 1.3.99.10 (isovaleryl-CoA dehydrogenase) or EC 1.3.99.13
(long-chain-acyl-CoA dehydrogenase). |
|---|
| Pathway |
PATH: ec00280 Valine, leucine and isoleucine degradation
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K09478 short/branched chain acyl-CoA dehydrogenase
KO: K11410 short/branched chain acyl-CoA dehydrogenase |
|---|
| Genes |
HSA: 36(ACADSB)
PTR: 745464(ACADSB)
MCC: 707487(ACADSB)
MMU: 66885(Acadsb)
RNO: 25618(Acadsb)
CFA: 477856(ACADSB)
BTA: 504301(ACADSB)
ECB: 100057998
MDO: 100025277
GGA: 423947(RCJMB04_12m17)
TGU: 100217590
XTR: 448259(acadsb)
DME: Dmel_CG3902
DPO: Dpse_GA17761
AAG: AaeL_AAEL007555
AME: 409712
CEL: K06A5.6(acdh-3)
SCO: SCO2779(acdH)
SMA: SAV_5275(fadE4)
SGR: SGR_4756
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:6401712]
Ikeda Y, Dabrowski C, Tanaka K.
Separation and properties of five distinct acyl-CoA dehydrogenases
from rat liver mitochondria. Identification of a new 2-methyl
branched chain acyl-CoA dehydrogenase.
J. Biol. Chem. 258 (1983) 1066-76.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.3.99.12
IUBMB Enzyme Nomenclature: 1.3.99.12
ExPASy - ENZYME nomenclature database: 1.3.99.12
BRENDA, the Enzyme Database: 1.3.99.12
CAS: 85130-32-1 |
|---|
