| Entry |
|
|---|
| Name |
benzoyl-CoA reductase;
benzoyl-CoA reductase (dearomatizing) |
|---|
| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With other acceptors
 |
|---|
| Sysname |
cyclohexa-1,5-diene-1-carbonyl-CoA:acceptor oxidoreductase
(aromatizing, ATP-forming) |
|---|
| Reaction(IUBMB) |
benzoyl-CoA + reduced acceptor + 2 ATP + 2 H2O =
cyclohexa-1,5-diene-1-carbonyl-CoA + acceptor + 2 ADP + 2 phosphate
[RN:R02451] |
|---|
| Reaction(KEGG) |
R02451;
(other) R00283
 |
|---|
| Substrate |
benzoyl-CoA [CPD:C00512];
reduced acceptor [CPD:C00030];
ATP [CPD:C00002];
H2O [CPD:C00001] |
|---|
| Product |
cyclohexa-1,5-diene-1-carbonyl-CoA [CPD:C06322];
acceptor [CPD:C00028];
ADP [CPD:C00008];
phosphate [CPD:C00009] |
|---|
| Cofactor |
Manganese [CPD:C00034];
Magnesium [CPD:C00305] |
|---|
| Comment |
An iron-sulfur protein. Requires Mg2+ or Mn2+. Reduced methyl
viologen can act as electron donor. Inactive towards aromatic acids
that are not CoA esters but will also catalyse the reaction: ammonia
+ acceptor + 2 ADP + 2 phosphate + H2O = hydroxylamine + reduced
acceptor + 2 ATP. In the presence of reduced acceptor, but in the
absence of oxidizable substrate, the enzyme catalyses the hydrolysis
of ATP to ADP plus phosphate. |
|---|
| Pathway |
PATH: ec00632 Benzoate degradation via CoA ligation
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K04112 benzoyl-CoA reductase subunit
KO: K04113 benzoyl-CoA reductase subunit
KO: K04114 benzoyl-CoA reductase subunit
KO: K04115 benzoyl-CoA reductase subunit |
|---|
| Genes |
RPA: RPA0657(badD) RPA0658(badE) RPA0659(badF) RPA0660(badG)
RPC: RPC_1026 RPC_1027 RPC_1028 RPC_1029
RPD: RPD_1535 RPD_1536 RPD_1537 RPD_1538
RPE: RPE_0605 RPE_0606 RPE_0607 RPE_0608
MAG: amb2138 amb2139 amb2140 amb2141
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:8575453]
Boll M, Fuchs G.
Benzoyl-coenzyme A reductase (dearomatizing), a key enzyme of
anaerobic aromatic metabolism. ATP dependence of the reaction,
purification and some properties of the enzyme from Thauera
aromatica strain K172.
Eur. J. Biochem. 234 (1995) 921-33.
Thauera aromatica |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.3.99.15
IUBMB Enzyme Nomenclature: 1.3.99.15
ExPASy - ENZYME nomenclature database: 1.3.99.15
UM-BBD (Biocatalysis/Biodegradation Database): 1.3.99.15
BRENDA, the Enzyme Database: 1.3.99.15
CAS: 176591-18-7 |
|---|
