| Entry |
|
|---|
| Name |
4-hydroxybenzoyl-CoA reductase;
4-hydroxybenzoyl-CoA reductase (dehydroxylating);
4-hydroxybenzoyl-CoA:(acceptor) oxidoreductase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With other acceptors
 |
|---|
| Sysname |
benzoyl-CoA:acceptor oxidoreductase |
|---|
| Reaction(IUBMB) |
benzoyl-CoA + acceptor + H2O = 4-hydroxybenzoyl-CoA + reduced
acceptor [RN:R05316] |
|---|
| Reaction(KEGG) |
R05316
 |
|---|
| Substrate |
benzoyl-CoA [CPD:C00512];
acceptor [CPD:C00028];
H2O [CPD:C00001] |
|---|
| Product |
4-hydroxybenzoyl-CoA [CPD:C02949];
reduced acceptor [CPD:C00030] |
|---|
| Comment |
A molybdenum-flavin-iron-sulfur protein that is involved in the
anaerobic pathway of phenol metabolism in bacteria. A ferredoxin
with two [4Fe-4S] clusters functions as the natural electron donor
[3] |
|---|
| Pathway |
PATH: ec00632 Benzoate degradation via CoA ligation
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K04107 4-hydroxybenzoyl-CoA reductase subunit 1
KO: K04108 4-hydroxybenzoyl-CoA reductase subunit 2
KO: K04109 4-hydroxybenzoyl-CoA reductase subunit 3 |
|---|
| Genes |
EBA: ebA3603(hcrA) ebA3604(hcrC)
RPA: RPA0670(hbaB) RPA0671(hbaC) RPA0672(hbaD)
RPC: RPC_1013 RPC_1014
RPD: RPD_1523 RPD_1524 RPD_1525
RPE: RPE_0589 RPE_0590 RPE_0591
MAG: amb2019 amb2020 amb2021
 |
|---|
| Structures |
PDB: 1RM6 1SB3 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:2753161]
Glockler R, Tschech A, Fuchs G.
Reductive dehydroxylation of 4-hydroxybenzoyl-CoA to benzoyl-CoA in
a denitrifying, phenol-degrading Pseudomonas species.
FEBS. Lett. 251 (1989) 237-40.
Pseudomonas sp. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:9683649]
Heider J, Boll M, Breese K, Breinig S, Ebenau-Jehle C, Feil U,
Gad'on N, Laempe D, Leuthner B, Mohamed ME, Schneider S, Burchhardt
G, Fuchs G.
Differential induction of enzymes involved in anaerobic metabolism
of aromatic compounds in the denitrifying bacterium Thauera
aromatica.
Arch. Microbiol. 170 (1998) 120-31.
Thauera aromatica |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:9490068]
Breese K, Fuchs G.
4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from the
denitrifying bacterium Thauera aromatica--prosthetic groups,
electron donor, and genes of a member of the
molybdenum-flavin-iron-sulfur proteins.
Eur. J. Biochem. 251 (1998) 916-23.
Thauera aromatica |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:8477729]
Brackmann R, Fuchs G.
Enzymes of anaerobic metabolism of phenolic compounds.
4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from a denitrifying
Pseudomonas species.
Eur. J. Biochem. 213 (1993) 563-71.
Pseudomonas sp. |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:9057820]
Heider J, Fuchs G.
Anaerobic metabolism of aromatic compounds.
Eur. J. Biochem. 243 (1997) 577-96.
Azoarcus evansii, Rhodopseudonmonas palustris, Thauera aromatica |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.3.99.20
IUBMB Enzyme Nomenclature: 1.3.99.20
ExPASy - ENZYME nomenclature database: 1.3.99.20
UM-BBD (Biocatalysis/Biodegradation Database): 1.3.99.20
BRENDA, the Enzyme Database: 1.3.99.20
CAS: 133758-58-4 |
|---|
