| Entry |
|
|---|
| Name |
acyl-CoA dehydrogenase;
acyl dehydrogenase;
fatty acyl coenzyme A dehydrogenase;
acyl coenzyme A dehydrogenase;
fatty-acyl-CoA dehydrogenase;
acyl CoA dehydrogenase;
general acyl CoA dehydrogenase;
medium-chain acyl-coenzyme A dehydrogenase;
medium-chain acyl-CoA dehydrogenase;
long-chain acyl coenzyme A dehydrogenase;
long-chain acyl-CoA dehydrogenase;
acyl-CoA:(acceptor) 2,3-oxidoreductase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With other acceptors
 |
|---|
| Sysname |
acyl-CoA:acceptor 2,3-oxidoreductase |
|---|
| Reaction(IUBMB) |
acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor
[RN:R00392] |
|---|
| Reaction(KEGG) |
R00392 > R00924 R01175 R01279 R02661 R03172 R03777 R03857 R03990
R04095 R04432 R04751 R04754
 |
|---|
| Substrate |
acyl-CoA [CPD:C00040];
acceptor [CPD:C00028] |
|---|
| Product |
2,3-dehydroacyl-CoA [CPD:C00605];
reduced acceptor [CPD:C00030] |
|---|
| Cofactor |
FAD [CPD:C00016] |
|---|
| Comment |
A flavoprotein; forms, with another flavoprotein
('electron-transferring flavoprotein') and EC 1.5.5.1
electron-transferring-flavoprotein dehydrogenase, a system reducing
ubiquinone and other acceptors. |
|---|
| Pathway |
PATH: ec00071 Fatty acid metabolism
PATH: ec00280 Valine, leucine and isoleucine degradation
PATH: ec00410 beta-Alanine metabolism
PATH: ec00640 Propanoate metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00249 acyl-CoA dehydrogenase |
|---|
| Genes |
HSA: 34(ACADM)
PTR: 469356(ACADM)
MCC: 705168(ACADM)
MMU: 11364(Acadm)
RNO: 24158(Acadm)
CFA: 490207(ACADM)
BTA: 505968(ACADM)
SSC: 397104(ACADM)
ECB: 100067343
OAA: 100074936
TGU: 100218051
XLA: 446467(acadm) 447486
DRE: 406283(acadm)
SPU: 591118
DME: Dmel_CG12262 Dmel_CG4586 Dmel_CG4860
DPO: Dpse_GA11516
DAN: Dana_GF10656
AGA: AgaP_AGAP005662
AAG: AaeL_AAEL014452
AME: 408567
TCA: 659081
CEL: K05F1.3(acdh-8) K09H11.1 T08G2.3(acdh-10) T25G12.5(acdh-7)
CBR: CBG15946
BMY: Bm1_33775
NVE: NEMVE_v1g125111
ATH: AT3G06810(IBR3)
CME: CML080C
AGO: AGOS_AFL213W
KLA: KLLA0E15246g
DHA: DEHA0B06424g
PIC: PICST_33103(ACD99)
NCR: NCU01181 NCU09885
MGR: MGG_08661
ANI: AN6761.2
AFM: AFUA_5G06500 AFUA_7G06510
AOR: AO090005000494 AO090009000596
ANG: An14g03240 An17g01150
CNE: CNJ01190 CNK00550
CNB: CNBK2940
UMA: UM01049.1 UM06400.1
MGL: MGL_3154
MBR: MONBRDRAFT_38510
TBR: Tb11.01.3640
TCR: 509153.120 510303.290
LMA: LmjF06.0880 LmjF28.2510
SPQ: SPAB_02636
SEI: SPC_0856
SEC: SC0851(acdC)
SEH: SeHA_C0989
SEE: SNSL254_A0928
SEW: SeSA_A1009
SED: SeD_A0960
SEG: SG0838
SET: SEN0803
SES: SARI_02573
STM: STM0857
PAY: PAU_00629
DDA: Dd703_3095
PAE: PA0879 PA1187 PA1535 PA2550 PA4435 PA4994
PAU: PA14_31580 PA14_35970 PA14_44590 PA14_49080(lcaD) PA14_51120
PA14_52900 PA14_66040
PPU: PP_2437 PP_2793
PPF: Pput_3258
PST: PSPTO_2745
PSB: Psyr_2176 Psyr_2474
PSP: PSPPH_2632 PSPPH_4712 PSPPH_4715
PFL: PFL_1908(fadE13) PFL_2648(acd-6) PFL_3931(fadE1)
PFL_5084(fadE20)
PFO: Pfl01_1809 Pfl01_3651 Pfl01_4696
PEN: PSEEN3343
PMY: Pmen_0599 Pmen_0898 Pmen_2439 Pmen_2640 Pmen_2971
PSA: PST_1694 PST_2197 PST_3552
ACI: ACIAD1566
ACB: A1S_1642 A1S_3012
ABM: ABSDF1861 ABSDF2875
ABY: ABAYE0476 ABAYE2013
SFR: Sfri_2069
SLO: Shew_2860 Shew_3003(fadE)
SSE: Ssed_3347
PHA: PSHAb0374(fadE)
PAT: Patl_1688 Patl_1812 Patl_3783
SDE: Sde_0166 Sde_3776
MAQ: Maqu_2118 Maqu_2399 Maqu_3438
FTU: FTT_1529(fadE)
FTF: FTF1529(fadE)
FTW: FTW_0402(fadE)
FTH: FTH_0585(fadE)
FTN: FTN_1437(fadE)
HHA: Hhal_1493
HCH: HCH_01061 HCH_02846 HCH_05789
ABO: ABO_0185(fadE-1) ABO_0186(fadE-2) ABO_0571 ABO_0957 ABO_1264
ABO_1701(acdA) ABO_1702 ABO_1772 ABO_2098(fadE) ABO_2533
ABO_2662
CVI: CV_1785 CV_2084(caiA) CV_3816
RSO: RS02011(RSp0036) RSc2020
RPI: Rpic_0104 Rpic_2177 Rpic_3835
RPF: Rpic12D_0111 Rpic12D_1854 Rpic12D_3948
REU: Reut_A1002 Reut_A2181 Reut_B3500 Reut_B3515 Reut_B3542
Reut_B3552 Reut_B3556 Reut_B3709 Reut_B3835 Reut_B3857
Reut_B3870 Reut_B4154 Reut_B4166 Reut_B4519 Reut_B4628
Reut_B4753 Reut_B5206 Reut_B5285 Reut_B5288 Reut_B5361
Reut_C6297 Reut_C6366
REH: H16_A0101 H16_A0460(acaD) H16_A0816 H16_A0843 H16_A0863
H16_A1067 H16_A1068 H16_A1091 H16_A1530 H16_A2458(abmD)
H16_A2596 H16_B0014 H16_B0087 H16_B0356 H16_B0360 H16_B0379
H16_B0383 H16_B0384 H16_B0395 H16_B0396 H16_B0400 H16_B0580
H16_B0660 H16_B0661 H16_B0664 H16_B0665 H16_B0676 H16_B0683
H16_B0699 H16_B0703 H16_B0704 H16_B0721 H16_B0722 H16_B0751
H16_B0849 H16_B0909 H16_B0913 H16_B0938 H16_B0975 H16_B1192
H16_B1332 H16_B1367 H16_B1481 H16_B1826 H16_B2157 H16_B2158
RME: Rmet_0845 Rmet_0968 Rmet_1814 Rmet_2199 Rmet_3412 Rmet_3727
Rmet_3899 Rmet_4410 Rmet_4458 Rmet_4574 Rmet_4575 Rmet_4613
Rmet_5024 Rmet_5133 Rmet_5152 Rmet_5357 Rmet_5358 Rmet_5437
Rmet_5837
CTI: RALTA_B1526
BMA: BMA0042 BMA1755 BMA1806 BMA3156
BMV: BMASAVP1_A0126 BMASAVP1_A1153 BMASAVP1_A2264 BMASAVP1_A2553
BMASAVP1_A2888
BML: BMA10229_A0715 BMA10229_A0929 BMA10229_A1462 BMA10229_A2197
BMA10229_A3054
BMN: BMA10247_0220 BMA10247_0436 BMA10247_1537 BMA10247_2510
BMA10247_2890
BPS: BPSL0061 BPSL0483 BPSL0614 BPSL1234 BPSL2329 BPSL2498 BPSS2029
BPM: BURPS1710b_0285 BURPS1710b_0705 BURPS1710b_0818 BURPS1710b_1459
BURPS1710b_2781 BURPS1710b_2975 BURPS1710b_A1147
BPL: BURPS1106A_0539 BURPS1106A_0655 BURPS1106A_1322 BURPS1106A_2703
BURPS1106A_2926 BURPS1106A_A2771
BPD: BURPS668_0521 BURPS668_0641 BURPS668_1313 BURPS668_2648
BURPS668_2865 BURPS668_A2926
BTE: BTH_I0060 BTH_I0531 BTH_I1083 BTH_I1655 BTH_I1833 BTH_II0292
BVI: Bcep1808_3880 Bcep1808_4782 Bcep1808_5764
BUR: Bcep18194_B1442 Bcep18194_B1805 Bcep18194_B3035 Bcep18194_C7425
BCN: Bcen_4153 Bcen_5016 Bcen_5651 Bcen_5810
BCH: Bcen2424_4213 Bcen2424_5844 Bcen2424_6016 Bcen2424_6174
BCM: Bcenmc03_3304
BAM: Bamb_3636 Bamb_5081 Bamb_6136
BXE: Bxe_A2526 Bxe_A2768 Bxe_A3188 Bxe_B0278 Bxe_B2584 Bxe_B2724
Bxe_B2741 Bxe_C0279 Bxe_C0426 Bxe_C0602 Bxe_C0604 Bxe_C0617
Bxe_C0655 Bxe_C0702 Bxe_C0852
PNU: Pnuc_0013 Pnuc_1388
BPE: BP0310 BP0625
BPA: BPP0575 BPP0585 BPP0613 BPP2810 BPP3941
BBR: BB0581 BB0591 BB0619 BB3131 BB4414 BB4702
BPT: Bpet0045(acd1) Bpet0552(acd4)
RFR: Rfer_0062 Rfer_0994 Rfer_1019 Rfer_2752 Rfer_3328 Rfer_3506
Rfer_3689
POL: Bpro_0583 Bpro_0590 Bpro_2961 Bpro_3014 Bpro_5265 Bpro_5275
Bpro_5284
PNA: Pnap_1911 Pnap_2142 Pnap_2701 Pnap_3620
AAV: Aave_0176 Aave_3077 Aave_3176 Aave_3812
AJS: Ajs_0062 Ajs_0103 Ajs_0230 Ajs_0232 Ajs_1777
VEI: Veis_0226 Veis_0496 Veis_1134 Veis_1197 Veis_1583 Veis_1896
Veis_2210 Veis_2503 Veis_3864 Veis_4039 Veis_4102 Veis_4306
Veis_4806
DAC: Daci_0198
DIA: Dtpsy_0078 Dtpsy_0120 Dtpsy_0224
MPT: Mpe_A1953
NEU: NE2348(fadE1)
NMU: Nmul_A0967
EBA: ebA5321 ebA5641 ebA736 p2A380
AZO: azo1702 azo1931(abmD) azo2494(aidB2)
APP: CAP2UW1_1659
GME: Gmet_3307
SAT: SYN_02586
PUB: SAR11_0249(mmgC)
MLO: mll3094 mll5430 mlr5042 mlr5626
MES: Meso_0023 Meso_0723 Meso_3278 Meso_3279 Meso_3281
PLA: Plav_0392 Plav_0925 Plav_1613 Plav_1624
SME: SMc01639
ATU: Atu2572(acd)
ATC: AGR_C_4660
RET: RHE_CH00557(acd1) RHE_CH00905(ypch00295) RHE_CH04044(acd2)
RHE_PC00127(ypc00065)
RLE: RL0591 RL0965 RL4596 pRL100145 pRL100376
BME: BMEI1521 BMEII0495
BMF: BAB1_0440 BAB2_0442
BMB: BruAb1_0435 BruAb2_0437
BMS: BR0412
BOV: BOV_0420
OAN: Oant_1476 Oant_4017
BJA: bll0958(acd) bll2940 bll6283(acd) bll6363 bll6377 bll6791
blr0119 blr0120 blr0138 blr0981 blr0982 blr2947 blr2989 blr3304
blr7270
BRA: BRADO0653 BRADO3126 BRADO6881 BRADO6906 BRADO7111
BBT: BBta_0668 BBta_3566 BBta_4293 BBta_7841
RPA: RPA0480 RPA0481 RPA0740 RPA0780 RPA0816 RPA0995 RPA1236 RPA1612
RPA1699 RPA1708 RPA1709 RPA1710 RPA1762 RPA2137 RPA3289 RPA4002
RPA4553 RPA4598 RPA4798 RPA4799
RPB: RPB_0216 RPB_0559 RPB_0992 RPB_1146 RPB_1238 RPB_3267 RPB_4074
RPB_4606 RPB_4641
RPC: RPC_0737 RPC_2051 RPC_2197 RPC_4699
RPD: RPD_0270 RPD_0612 RPD_0767 RPD_0804 RPD_1095 RPD_1248 RPD_2198
RPD_3810 RPD_4007
RPE: RPE_0073 RPE_0119 RPE_0120 RPE_0532 RPE_0534 RPE_0672 RPE_0889
RPE_2248 RPE_3619 RPE_3822 RPE_3823 RPE_4126 RPE_4308
XAU: Xaut_1346
MEX: Mext_4597
MCH: Mchl_5058
CCR: CC_0079 CC_0690 CC_1110 CC_2328 CC_3087 CC_3454
SIL: SPO0575(acdA-1) SPO0693 SPO0879 SPO2538 SPO2698
SPOA0288(acdA-3) SPOA0403
SIT: TM1040_2239
RSP: RSP_1679
RSH: Rsph17029_0312
RSQ: Rsph17025_2567
JAN: Jann_0530 Jann_1327 Jann_2811 Jann_2970 Jann_3822
RDE: RD1_0611(acdA) RD1_1372(ibd2) RD1_2065 RD1_3969
PDE: Pden_2840 Pden_5091
DSH: Dshi_0204(mmgC) Dshi_1004
MMR: Mmar10_0539 Mmar10_1651 Mmar10_1653 Mmar10_1654 Mmar10_2691
HNE: HNE_0278 HNE_0516 HNE_0669 HNE_0809 HNE_1134 HNE_2441 HNE_2442
HNE_2690(mmgC) HNE_2770 HNE_2772 HNE_2795
NAR: Saro_1705 Saro_2511
SAL: Sala_2313 Sala_3053
SWI: Swit_0824 Swit_1479
ELI: ELI_11490
ACR: Acry_2113 Acry_2577
MAG: amb0308 amb2588
BCZ: BCZK2285(bcd) BCZK2818(acdA) BCZK4732(acdA) BCZK5041
BTK: BT9727_2128(mmgC) BT9727_2327(acdA) BT9727_4717(acdA)
BTL: BALH_2096(mmgC) BALH_2288(bcd) BALH_2769(acdA) BALH_4545(acdA)
OIH: OB0670 OB0674 OB2667 OB3010(acdA) OB3011
GKA: GK1028 GK1316 GK1654 GK2780 GK3393
GTN: GTNG_0890 GTNG_1171 GTNG_1503 GTNG_3338
MTU: Rv0131c(fadE1) Rv0154c(fadE2) Rv0231(fadE4) Rv0975c(fadE13)
Rv3140(fadE23)
MTC: MT0139 MT0163 MT0241 MT1003 MT1719 MT2796 MT3227
MRA: MRA_0138(fadE1) MRA_0162(fadE2) MRA_0239(fadE4)
MRA_0982(fadE13) MRA_1690(fadE16) MRA_3173(fadE23)
MBO: Mb0136c(fadE1) Mb0159c(fadE2) Mb0236(fadE4) Mb1000c(fadE13)
Mb2743c(fadE20) Mb3164(fadE23)
MBB: BCG_0165c(fadE1) BCG_0190c(fadE2) BCG_0268(fadE4)
BCG_1029c(fadE13) BCG_3163(fadE23)
MBT: JTY_0135(fadE1) JTY_0160(fadE2)
MLE: ML0660(fadE23)
MPA: MAP0723 MAP0913c(fadE13) MAP1713 MAP3189(fadE23) MAP3539c
MAP3570c(fadE2) MAP3669(fadE4) MAP3877c
MAV: MAV_0039 MAV_1091 MAV_1267 MAV_1813 MAV_1877 MAV_1896 MAV_2553
MAV_2554 MAV_2606 MAV_2703 MAV_4019 MAV_4939 MAV_5144 MAV_5173
MSM: MSMEG_0102 MSMEG_2080 MSMEG_4826 MSMEG_4832 MSMEG_5491
MUL: MUL_1151(fadE4) MUL_2432(fadE23) MUL_2756 MUL_2757
MUL_4704(fadE13) MUL_4790(fadE1)
MVA: Mvan_0116 Mvan_0281 Mvan_1906 Mvan_4200 Mvan_4205 Mvan_4210
Mvan_4847 Mvan_5722
MGI: Mflv_0398 Mflv_0734 Mflv_1095 Mflv_1884 Mflv_2442 Mflv_2446
Mflv_2451 Mflv_4456 Mflv_4601 Mflv_4612 Mflv_5167
MAB: MAB_0328 MAB_1073c MAB_1851 MAB_1863 MAB_2081 MAB_3481 MAB_3487
MAB_4911c
MMC: Mmcs_0098 Mmcs_0212 Mmcs_0213 Mmcs_1603 Mmcs_3185 Mmcs_3735
Mmcs_3740 Mmcs_4305
MKM: Mkms_0107 Mkms_0222 Mkms_0223 Mkms_1627 Mkms_3247 Mkms_3808
Mkms_3817 Mkms_4391
MJL: Mjls_0088 Mjls_0202 Mjls_0203 Mjls_1573 Mjls_3197 Mjls_3747
Mjls_3752 Mjls_3756 Mjls_4077 Mjls_4155 Mjls_4685
CJK: jk0229(fadE2) jk0296(fadE4) jk1462(fadE6) jk1479(fadE7)
NFA: nfa21770(fadE19) nfa22680(fadE21) nfa24990(fadE26)
nfa25560(fadE27) nfa25620 nfa33820(fadE30) nfa34080(fadE31)
nfa35440(fadE33) nfa38250(fadE35) nfa40720 nfa4420(fadE1)
nfa44930(fadE38) nfa53310(fadE45)
RHA: RHA1_ro01875 RHA1_ro01932 RHA1_ro02214 RHA1_ro02297
RHA1_ro02341 RHA1_ro02696 RHA1_ro03059 RHA1_ro03093
RHA1_ro03965 RHA1_ro04596 RHA1_ro04636 RHA1_ro04692(fadE27)
RHA1_ro04693(fadE26) RHA1_ro04748 RHA1_ro04754 RHA1_ro05247
RHA1_ro05713 RHA1_ro05756 RHA1_ro05827 RHA1_ro05896
RHA1_ro06399 RHA1_ro06629 RHA1_ro06682 RHA1_ro07119
RHA1_ro08438 RHA1_ro09029 RHA1_ro10128 RHA1_ro10306
RHA1_ro10307 RHA1_ro10357
SCO: SCO1690(SCI30A.11) SCO2774(acdH2) SCO6787(acdH3)
SMA: SAV_1381(fadE15) SAV_5280(fadE7) SAV_6614(fadE17)
KRH: KRH_20400
NCA: Noca_0046 Noca_1832 Noca_2604 Noca_4554
TFU: Tfu_1282 Tfu_1512 Tfu_1647 Tfu_1999 Tfu_2485
FRA: Francci3_0940 Francci3_1193 Francci3_3276
FRE: Franean1_1886
FAL: FRAAL1585 FRAAL2829 FRAAL3513 FRAAL3514 FRAAL4769
SEN: SACE_2743(fadE22) SACE_2745(fadE21) SACE_2758 SACE_2850(acdA-3)
SACE_3126(fadE13) SACE_3565 SACE_4125(fadE1) SACE_5017(acdA)
SACE_5025 SACE_5380(fadE31) SACE_5699
STP: Strop_0683 Strop_1562 Strop_4326
SAQ: Sare_1049
CAI: Caci_6321
RXY: Rxyl_2278 Rxyl_2418 Rxyl_2735
LIL: LA0560 LA1130(fadE1) LA1930 LA3143 LA3363 LA3627 LA3676
LA3928(fadE2) LA4117
LIC: LIC10583 LIC11350 LIC11976 LIC12551(acd3) LIC13009 LIC13281
LBJ: LBJ_1583(caiA-2) LBJ_2860
LBL: LBL_0211 LBL_1801(caiA-2)
LBI: LEPBI_I3333
GAU: GAU_3272
RRS: RoseRS_2971
DRA: DR_1318 DR_A0196
DGE: Dgeo_0736 Dgeo_2399
TTJ: TTHB015
AFU: AF0498(acd-3) AF0964(acd-6)
HMA: rrnAC1983(acdI) rrnB0264(acdH)
HWA: HQ2389A(acd)
NPH: NP1596A(acd_5) NP1754A(acd_11) NP1870A(acd_9) NP2628A(acd_2)
NP2934A(acd_7) NP3004A(acd_6) NP3460A(acd_3) NP4050A(acd_10)
NP4214A(acd_12) NP4254A(acd_4) NP6180A(acd_8)
HLA: Hlac_0221
TAC: Ta0295m Ta0398
TVO: TVN1175 TVN1305
PTO: PTO0830 PTO1024 PTO1459
APE: APE_0385.1 APE_0739 APE_1681.1 APE_2158.1 APE_2354
MSE: Msed_0274
PAI: PAE2070
PIS: Pisl_1853
PCL: Pcal_0199 Pcal_1313
PAS: Pars_2103
CMA: Cmaq_0556
TNE: Tneu_1268
KCR: Kcr_1036
 |
|---|
| Structures |
PDB: 1EGC 1EGD 1EGE 1T9G 1UDY 1UKW 2A1T 2CX9 2PG0 2Z1Q
3MDD 3MDE |
|---|
Reference
Authors
Title
Journal
|
1
Beinert, H.
Acyl coenzyme A dehydrogenase.
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd
ed., vol. 7, Academic Press, New York, 1963, p. 447-466. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:13295224]
CRANE FL, MII S, HAUGE JG, GREEN DE, BEINERT H.
On the mechanism of dehydrogenation of fatty acyl derivatives of
coenzyme A. I. The general fatty acyl coenzyme A dehydrogenase.
J. Biol. Chem. 218 (1956) 701-6.
Sus scofa [GN:ssc] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13319294]
HAUGE JG, CRANE FL, BEINERT H.
On the mechanism of dehydrogenation of fatty acyl derivatives of
coenzyme A. III. Palmityl coA dehydrogenase.
J. Biol. Chem. 219 (1956) 727-33.
Sus scofa [GN:ssc] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.3.99.3
IUBMB Enzyme Nomenclature: 1.3.99.3
ExPASy - ENZYME nomenclature database: 1.3.99.3
BRENDA, the Enzyme Database: 1.3.99.3
CAS: 9027-65-0 |
|---|
