KEGG   ENZYME: 1.3.99.5Help
Entry
EC 1.3.99.5                 Enzyme                                 
Name 3-oxo-5alpha-steroid 4-dehydrogenase;
steroid 5alpha-reductase;
3-oxosteroid Delta4-dehydrogenase;
3-oxo-5alpha-steroid Delta4-dehydrogenase;
steroid Delta4-5alpha-reductase;
Delta4-3-keto steroid 5alpha-reductase;
Delta4-3-oxo steroid reductase;
Delta4-3-ketosteroid5alpha-oxidoreductase;
Delta4-3-oxosteroid-5alpha-reductase;
3-keto-Delta4-steroid-5alpha-reductase;
5alpha-reductase;
testosterone 5alpha-reductase;
4-ene-3-ketosteroid-5alpha-oxidoreductase;
Delta4-5alpha-dehydrogenase;
3-oxo-5alpha-steroid:(acceptor) Delta4-oxidoreductase
Class Oxidoreductases;
Acting on the CH-CH group of donors;
With other acceptors
BRITE hierarchy
Sysname 3-oxo-5alpha-steroid:acceptor Delta4-oxidoreductase
Reaction(IUBMB) a 3-oxo-5alpha-steroid + acceptor = a 3-oxo-Delta4-steroid + reduced
acceptor [RN:R02643]
Reaction(KEGG) R02643 > R01834 R02497 R04827
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Substrate 3-oxo-5alpha-steroid [CPD:C02940];
acceptor [CPD:C00028]
Product 3-oxo-Delta4-steroid [CPD:C00619];
reduced acceptor [CPD:C00030]
Pathway PATH: ec00140  Steroid hormone biosynthesis
Orthology KO: K12343  3-oxo-5-alpha-steroid 4-dehydrogenase 1
KO: K12344  3-oxo-5-alpha-steroid 4-dehydrogenase 2
KO: K12345  3-oxo-5-alpha-steroid 4-dehydrogenase 3
Genes HSA: 6715(SRD5A1) 6716(SRD5A2) 79644(SRD5A3)
PTR: 471241(SRD5A3) 743740(SRD5A1)
MCC: 695103(SRD5A1) 696381(SRD5A3) 705676(SRD5A2)
MMU: 100044230 78925(Srd5a1) 94224(Srd5a2)
RNO: 24950(Srd5a1) 305291(Srd5a3) 64677(Srd5a2)
CFA: 403715(SRD5A2) 403716(SRD5A1) 482155(SRD5A3)
BTA: 527024(SRD5A2) 535834(SRD5A3) 614612(SRD5A1)
SSC: 397048(ST5AR2)
ECB: 100059582 100070655 100071450
MDO: 100017228
OAA: 100078235
GGA: 422750(SRD5A3) 772291(SRD5A2)
TGU: 100224163 100225484
XLA: 100049757 379123(srd5a3)
XTR: 448586(srd5a1) 549867(srd5a2) 779994(srd5a3)
DRE: 550398 560717(srd5a3) 767715(srd5a1)
BFO: BRAFLDRAFT_220169 BRAFLDRAFT_225387 BRAFLDRAFT_274883
CIN: 100181505 100186253
DME: Dmel_CG7840
DPO: Dpse_GA20623
DAN: Dana_GF14631
DER: Dere_GG10530
DPE: Dper_GL18734
DSE: Dsec_GM16876
DSI: Dsim_GD23520
DYA: Dyak_GE18750
DGR: Dgri_GH11587
DMO: Dmoj_GI17156
AGA: AgaP_AGAP007493
AAG: AaeL_AAEL012055
CQU: CpipJ_CPIJ008625
NVI: 100119448
API: 100167163
ISC: IscW_ISCW012662
CEL: B0024.13 F42F12.3
CBR: CBG00143 CBG09584
BMY: Bm1_06570
NVE: NEMVE_v1g101187 NEMVE_v1g88448
HMG: 100197205
TAD: TRIADDRAFT_53471 TRIADDRAFT_58245 TRIADDRAFT_59840
ATH: AT1G72590
POP: POPTR_557164 POPTR_576916 POPTR_595475
RCU: RCOM_0085180 RCOM_1450960
VVI: 100243811 100261294(GSVIVT00021458001) 100265912
OSA: 4324809(Os01g0851600) 4336740(Os04g0576800)
SBI: SORBI_03g040050(SORBIDRAFT_03g040050)
ZMA: 100194237(cl34681_1b) 100283443
PPP: PHYPADRAFT_119780 PHYPADRAFT_166483
CRE: CHLREDRAFT_120014 CHLREDRAFT_192416
OLU: OSTLU_24166
CME: CMO284C CMP066C
SCE: YIL049W(DFG10)
AGO: AGOS_ADL073W
KLA: KLLA0C08261g
LTH: KLTH0A04312g
DHA: DEHA0B09856g
PIC: PICST_31592(DFG10)
PPA: PAS_chr1-4_0673
VPO: Kpol_1009p22
LEL: LELG_02555
ZRO: ZYRO0D16852g
CAL: CaO19.209(DFG10)
CTP: CTRG_01961
CDU: CD36_23150(DFG10)
CGR: CAGL0L00693g
SPO: SPAC7D4.09c SPAC9.08c
PAN: PODANSg4842 PODANSg6407
MGR: MGG_03905 MGG_13163
FGR: FG01618.1 FG07239.1
ANI: AN4071.2
AFM: AFUA_1G05470 AFUA_4G07350
AOR: AO090009000397 AO090023000838
ANG: An04g01740 An18g04290
AFV: AFLA_050780 AFLA_112480
PCS: Pc18g02350 Pc22g18520
NFI: NFIA_019290 NFIA_108870
CIM: CIMG_03924 CIMG_04063
SSL: SS1G_10930
BFU: BC1G_12285
CNB: CNBA3370
LBC: LACBIDRAFT_312049
UMA: UM04015.1
MGL: MGL_3451
MBR: MONBRDRAFT_13728
EHI: EHI_197070
EDI: EDI_121990
PFH: PFHG_00677
PKN: PKH_125020
PVX: PVX_117670
TGO: TGME49_104480
TET: TTHERM_01001550
PTM: GSPATT00031296001
TBR: Tb927.8.2480
TCR: 504427.70 509331.70
LMA: LmjF17.1100
LIF: LinJ17.1220
LBZ: LbrM17_V2.1210
TVA: TVAG_096490 TVAG_391520
PTI: PHATRDRAFT_17044(DET2)
TPS: THAPSDRAFT_264431
BAV: BAV0747
LLA: L176238(yfhH)
MUL: MUL_3208
MAB: MAB_2819
MMI: MMAR_2552
NFA: nfa45190
TDE: TDE2697
BTH: BT_2068
BFR: BF3752
BFS: BF3540
BVU: BVU_1964
Taxonomy
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:13673006]
LEVY HR, TALALAY P.
Bacterial oxidation of steroids. II. Studies on the enzymatic
mechanism of ring A dehydrogenation.
J. Biol. Chem. 234 (1959) 2014-21.
Pseudomonas testosteroni
Other DBs ExplorEnz - The Enzyme Database: 1.3.99.5
IUBMB Enzyme Nomenclature: 1.3.99.5
ExPASy - ENZYME nomenclature database: 1.3.99.5
BRENDA, the Enzyme Database: 1.3.99.5
CAS: 9036-43-5
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