KEGG   ENZYME: 1.3.99.7Help
Entry
EC 1.3.99.7                 Enzyme                                 
Name glutaryl-CoA dehydrogenase;
glutaryl coenzyme A dehydrogenase;
glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating)
Class Oxidoreductases;
Acting on the CH-CH group of donors;
With other acceptors
BRITE hierarchy
Sysname glutaryl-CoA:acceptor 2,3-oxidoreductase (decarboxylating)
Reaction(IUBMB) glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor
[RN:R02488]
Reaction(KEGG) R02488 > R02487;
(other) R05579
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Substrate glutaryl-CoA [CPD:C00527];
acceptor [CPD:C00028]
Product crotonoyl-CoA [CPD:C00877];
CO2 [CPD:C00011];
reduced acceptor [CPD:C00030]
Cofactor FAD [CPD:C00016]
Comment A flavoprotein.
Pathway PATH: ec00071  Fatty acid metabolism
PATH: ec00310  Lysine degradation
PATH: ec00380  Tryptophan metabolism
PATH: ec00632  Benzoate degradation via CoA ligation
PATH: ec01100  Metabolic pathways
Orthology KO: K00252  glutaryl-CoA dehydrogenase
Genes HSA: 2639(GCDH)
PTR: 455754(GCDH)
MCC: 716935(GCDH)
MMU: 270076(Gcdh)
RNO: 364975(Gcdh)
CFA: 476696(GCDH)
BTA: 506310(GCDH)
ECB: 100063310
MDO: 100027487
OAA: 100079305
XLA: 446458(gcdh)
XTR: 549043(TGas142f10.1)
DRE: 393860(gcdh)
BFO: BRAFLDRAFT_281524
CIN: 100184635
SPU: 580832
DME: Dmel_CG9547
DPO: Dpse_GA21870
DAN: Dana_GF15703
DER: Dere_GG23615
DPE: Dper_GL26099
DSE: Dsec_GM17931
DSI: Dsim_GD22569
DYA: Dyak_GE18434
DGR: Dgri_GH13244
DMO: Dmoj_GI17285
AGA: AgaP_AGAP008501
AAG: AaeL_AAEL013642
CQU: CpipJ_CPIJ000375
AME: 410254
NVI: 100117653
TCA: 660326
API: 100163339(Acypi004433)
ISC: IscW_ISCW010793
CEL: F54D5.7
CBR: CBG02861
NVE: NEMVE_v1g159736
HMG: 100204769
TAD: TRIADDRAFT_63329
POP: POPTR_717426
VVI: 100257352
OSA: 4337904(Os05g0163700)
SBI: SORBI_06g001260(SORBIDRAFT_06g001260)
ZMA: 100282107
PPP: PHYPADRAFT_186552
CRE: CHLREDRAFT_40101
YLI: YALI0F23749g
NCR: NCU02291
PAN: PODANSg1796
MGR: MGG_06561
FGR: FG10804.1
ANI: AN2762.2
AFM: AFUA_3G06040
AOR: AO090020000074
ANG: An11g10470
AFV: AFLA_103330
PCS: Pc20g07920
NFI: NFIA_071210
CIM: CIMG_00502
URE: UREG_00537
SSL: SS1G_11174
BFU: BC1G_14595
CNE: CNG03020
CNB: CNBG1740
LBC: LACBIDRAFT_296371(GCD)
MPR: MPER_00969
UMA: UM01335.1
MBR: MONBRDRAFT_32637
DDI: DDB_0234151(gcdh) DDB_0237713
TGO: TGME49_031900
TET: TTHERM_00138150 TTHERM_00313080
PTM: GSPATT00008387001 GSPATT00021665001 GSPATT00023352001
     GSPATT00024907001
TCR: 508951.40 510121.40
PTI: PHATR_25572
TPS: THAPSDRAFT_23830(GCD1)
XCC: XCC1429(gcdH)
XCB: XC_2809
XCA: xccb100_2869(gcdH)
XCV: XCV1529
XAC: XAC1472(gcdH)
XOO: XOO1517(gcdH)
XOM: XOO_1408
XOP: PXO_04805
SML: Smlt0199(GCDH)
SMT: Smal_0159
PAE: PA0447(gcdH)
PAU: PA14_05840(gcdH)
PAP: PSPA7_0549(gcdH)
PAG: PLES_04431(gcdH)
PPU: PP_0158(gcdH)
PPF: Pput_0177
PPG: PputGB1_0175
PPW: PputW619_5068
PST: PSPTO_5461
PSB: Psyr_5014
PFL: PFL_0117(gcdH)
PFO: Pfl01_0117
PFS: PFLU0115
PEN: PSEEN0120(gcdH)
PMY: Pmen_4429
PSA: PST_0442(gcdH)
AVN: Avin_24930
PAR: Psyc_0805(gcdH)
PCR: Pcryo_0815
PRW: PsycPRwf_1536
ACI: ACIAD1660(gcdH)
ACB: A1S_0721
ABM: ABSDF2744(gcdH)
ABY: ABAYE3097(gcdH)
ABC: ACICU_00662
ABN: AB57_0766
ABB: ABBFA_002896
SDN: Sden_3018
SAZ: Sama_2796
SLO: Shew_0900
SSE: Ssed_0984
SWD: Swoo_1033
ILO: IL0178
CPS: CPS_4667(gcdH)
PAT: Patl_3993
MAQ: Maqu_3322
LPN: lpg2580(gcdH)
LPF: lpl2502(gcdH)
LPP: lpp2632(gcdH)
LPC: LPC_0567(gcdH)
HCH: HCH_06122
ABO: ABO_0984(gcdH)
AHA: AHA_1250
KKO: Kkor_1207
CVI: CV_3918
LHK: LHK_02894
RSO: RSc0756(gcdH)
RPI: Rpic_0706
RPF: Rpic12D_0772
REU: Reut_A0805
REH: H16_A2818(gcdH)
RME: Rmet_2653
CTI: RALTA_A2307(gcdH)
BMA: BMA2064(gcdH)
BMV: BMASAVP1_A0845(gcdH)
BML: BMA10229_A2678(gcdH)
BMN: BMA10247_1931
BPS: BPSL2747
BPM: BURPS1710b_3237
BPL: BURPS1106A_3222
BPD: BURPS668_3185
BPR: GBP346_A3363
BTE: BTH_I1390
BVI: Bcep1808_0749
BUR: Bcep18194_A3906 Bcep18194_B1396
BCN: Bcen_0330
BCH: Bcen2424_0813
BCM: Bcenmc03_0782
BCJ: BCAL3191
BAM: Bamb_0694
BAC: BamMC406_0711
BMU: Bmul_2570
BMJ: BMULJ_00668(gcdH)
BXE: Bxe_A3904
BPH: Bphy_2438
BPY: Bphyt_0776
BGL: bglu_1g06890
PNU: Pnuc_0818
PNE: Pnec_1021
BPE: BP1537(gcdH)
BPA: BPP0656(gcdH) BPP1209(gcdH)
BBR: BB0663(gcdH) BB1426(gcdH)
BPT: Bpet3566(acd14)
BAV: BAV0901(gcdH)
RFR: Rfer_4070
POL: Bpro_1671
PNA: Pnap_1133 Pnap_2130
AAV: Aave_1982
AJS: Ajs_2979
VEI: Veis_1734
DAC: Daci_2207
DIA: Dtpsy_2407
VAP: Vapar_0118
CTT: CtCNB1_3613
MPT: Mpe_A3170
LCH: Lcho_1193
EBA: ebA2993(gcdH)
AZO: azo1924(gcdH1) azo1930(gcdH2)
DAR: Daro_0539
TMZ: Tmz1t_0419
APP: CAP2UW1_3028
GME: Gmet_2075
SCL: sce1991
HOH: Hoch_4889
MLO: mll2878
MES: Meso_2481
PLA: Plav_0821
SME: SM_b21181
SMD: Smed_4671
ATU: Atu4418(gcdH)
ATC: AGR_L_896
ARA: Arad_8277(gcdH)
AVI: Avi_5908(gcdH)
RET: RHE_PE00272(gcdH)
REC: RHECIAT_CH0002307(gcdHch) RHECIAT_PA0000217(gcdHa)
RLE: pRL110386
RLT: Rleg2_5829
RLG: Rleg_6742
RHI: NGR_b13350(gcdH)
BME: BMEI0897
BMF: BAB1_1109
BMB: BruAb1_1091
BMC: BAbS19_I10280
BMS: BR1085
BMT: BSUIS_A1132
BCS: BCAN_A1103(acdA)
BMR: BMI_I1097
OAN: Oant_2170
BJA: blr2616(gcdH)
BRA: BRADO2134(gcdH)
BBT: BBta_2451(gcdH)
RPA: RPA1094
RPB: RPB_1162
RPC: RPC_1037 RPC_4297
RPD: RPD_1264
RPE: RPE_4356
RPT: Rpal_1284
NWI: Nwi_0608
NHA: Nham_0753
OCA: OCAR_6920
XAU: Xaut_4712
AZC: AZC_3558
MRD: Mrad2831_5095
MET: M446_1649
MNO: Mnod_1268
PZU: PHZ_c0291(gcdH)
SIL: SPO1955(gcdH)
SIT: TM1040_1255
RSP: RSP_1295
RSH: Rsph17029_2955
RSQ: Rsph17025_2728
RSK: RSKD131_2695
JAN: Jann_2813 Jann_3069
RDE: RD1_3956(gcdH)
PDE: Pden_4412
DSH: Dshi_2357
MMR: Mmar10_1661
HBA: Hbal_2510
NAR: Saro_3419
SAL: Sala_2879
SWI: Swit_0822 Swit_4233
ELI: ELI_09200
ACR: Acry_0857
RRU: Rru_A2005
RCE: RC1_0143(gcdH)
MAG: amb3231
SAU: SA0225
SAV: SAV0233
SAW: SAHV_0232
SAM: MW0209
SAR: SAR0225(fadD)
SAS: SAS0209
SAC: SACOL0213
SAA: SAUSA300_0227(fadD)
SAX: USA300HOU_0242
SAO: SAOUHSC_00197
SAJ: SaurJH9_0217
SAH: SaurJH1_0223
SAE: NWMN_0169(fadD)
SAD: SAAV_0198
SSP: SSP2425
SCA: Sca_2408
SUB: SUB1805
MTU: Rv0400c(fadE7)
MTC: MT0410
MRA: MRA_0406(fadE7)
MTF: TBFG_10405
MTB: TBMG_00401(TBMG_00401.1)
MBO: Mb0406c(fadE7)
MBB: BCG_0437c(fadE7)
MBT: JTY_0407(fadE7)
MPA: MAP3878c(fadE7)
MAV: MAV_4767
MSM: MSMEG_2466 MSMEG_5267 MSMEG_6686
MUL: MUL_2825(fadE7)
MVA: Mvan_1857 Mvan_4671
MGI: Mflv_4513
MAB: MAB_0822 MAB_4609c
MMC: Mmcs_4147
MKM: Mkms_4222
MJL: Mjls_4378
MMI: MMAR_0698(fadE7)
CGL: NCgl0283(cgl0288)
CGB: cg0346(fadE)
CGT: cgR_0374
CEF: CE0324 CE0723 CE0729 CE2777
CJK: jk0194(fadE1)
CAR: cauri_0583 cauri_0633(fadE1) cauri_0874(fadE2)
NFA: nfa48280(fadE41)
RHA: RHA1_ro02304
RER: RER_48470(gcdH)
ROP: ROP_20160(gcdH) ROP_23800(gcdH)
GBR: Gbro_4408
SCO: SCO1750(2SCI34.03c)
SMA: SAV_1347(gcdH2) SAV_6542(fadE12) SAV_719(gcdH1)
SGR: SGR_5750
CMI: CMM_1026(gcdH)
CMS: CMS_0642C
ART: Arth_0434 Arth_0610 Arth_1365 Arth_3055 Arth_3822
AAU: AAur_0510 AAur_0756 AAur_0963 AAur_3029
ACH: Achl_0638 Achl_0739 Achl_1382 Achl_2757
RSA: RSal33209_0084 RSal33209_0176 RSal33209_0902 RSal33209_1844
     RSal33209_2129
KRH: KRH_00720 KRH_05060 KRH_16510
MLU: Mlut_02900 Mlut_03070 Mlut_19560 Mlut_23170
BFA: Bfae_30270
XCE: Xcel_0223
NCA: Noca_4292
TFU: Tfu_1068
TCU: Tcur_0541
SRO: Sros_5749 Sros_6905 Sros_9061
NML: Namu_0031 Namu_0871 Namu_0874
KRA: Krad_3505
SEN: SACE_1911(fadE7) SACE_5409(gcdH2)
SVI: Svir_17470
STP: Strop_0429
SAQ: Sare_0517
CAI: Caci_8460
RXY: Rxyl_1746 Rxyl_2061
ABA: Acid345_0610
ACA: ACP_0176(gcdH)
SUS: Acid_0040
SRU: SRU_0115(gcdH) SRU_1116
RMR: Rmar_1436
CHU: CHU_1408(caiA)
DFE: Dfer_2638 Dfer_5685
CPI: Cpin_2231 Cpin_3323
PHE: Phep_1209 Phep_2329
GFO: GFO_0313
FJO: Fjoh_1290
FPS: FP0347(gcdH)
FBA: FIC_01341
RBI: RB2501_04215
GAU: GAU_2471(gcdH)
CAU: Caur_3557 Caur_3845
CAG: Cagg_0077 Cagg_0098
CHL: Chy400_3838
HAU: Haur_3470
DRA: DR_0551 DR_A0337
DGE: Dgeo_1221 Dgeo_2761
DDR: Deide_2p01400
TTH: TTC0435
TTJ: TTHA0789
AFU: AF0991(gcdH)
HAL: VNG2499G(gcdH)
HSL: OE4500R(acd6)
HMA: rrnAC1972(gcdH)
NPH: NP2620A(acd_1)
HLA: Hlac_2578
HMU: Hmuk_1120
Taxonomy
Structures PDB: 1SIQ  1SIR  2EBA  2R0M  2R0N  3D6B  3EOM  3EON  3GNC  3GQT  
     3II9  
Reference
  Authors
  Title
  Journal
  Organism
 1  [PMID:4304226]
Besrat A, Polan CE, Henderson LM.
Mammalian metabolism of glutaric acid.
J. Biol. Chem. 244 (1969) 1461-7.
Bos taurus [GN:bta]
Other DBs ExplorEnz - The Enzyme Database: 1.3.99.7
IUBMB Enzyme Nomenclature: 1.3.99.7
ExPASy - ENZYME nomenclature database: 1.3.99.7
UM-BBD (Biocatalysis/Biodegradation Database): 1.3.99.7
BRENDA, the Enzyme Database: 1.3.99.7
CAS: 37255-38-2
DBGET integrated database retrieval system