| Entry |
|
|---|
| Name |
glutamate dehydrogenase;
glutamic dehydrogenase;
glutamate dehydrogenase (NAD+);
glutamate oxidoreductase;
glutamic acid dehydrogenase;
L-glutamate dehydrogenase;
NAD+-dependent glutamate dehydrogenase;
NAD+-dependent glutamic dehydrogenase;
NAD+-glutamate dehydrogenase;
NAD+-linked glutamate dehydrogenase;
NAD+-linked glutamic dehydrogenase;
NAD+-specific glutamic dehydrogenase;
NAD+-specific glutamate dehydrogenase;
NAD+:glutamate oxidoreductase;
NADH-linked glutamate dehydrogenase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
L-glutamate:NAD+ oxidoreductase (deaminating) |
|---|
| Reaction(IUBMB) |
L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+
[RN:R00243] |
|---|
| Reaction(KEGG) |
R00243;
(other) R00145 R00146
 |
|---|
| Substrate |
L-glutamate [CPD:C00025];
H2O [CPD:C00001];
NAD+ [CPD:C00003] |
|---|
| Product |
2-oxoglutarate [CPD:C00026];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080] |
|---|
| Pathway |
PATH: ec00250 Alanine, aspartate and glutamate metabolism
PATH: ec00330 Arginine and proline metabolism
PATH: ec00910 Nitrogen metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00260 glutamate dehydrogenase |
|---|
| Genes |
OAA: 100092715
SCE: YDL215C(GDH2)
AGO: AGOS_AGL040C
KLA: KLLA0D08481g
LTH: KLTH0B07172g
DHA: DEHA0C11066g
PIC: PICST_78004(GDH2)
PPA: PAS_chr2-1_0311
VPO: Kpol_1041p10
LEL: LELG_01933
ZRO: ZYRO0C09834g
CAL: CaO19.2192(GDH2) CaO19.9738(GDH2)
CTP: CTRG_01673
CDU: CD36_22140
CGR: CAGL0G05698g
YLI: YALI0E09603g
SPO: SPCC132.04c
NCR: NCU00461
PAN: PODANSg5013
MGR: MGG_05247
FGR: FG04117.1
ANI: AN7451.2
AFM: AFUA_2G06000
AOR: AO090001000717
ANG: An02g14590
AFV: AFLA_130150
PCS: Pc22g08300
NFI: NFIA_082760
CIM: CIMG_00981
URE: UREG_00930
SSL: SS1G_00002
BFU: BC1G_15454
CNE: CND00180
CNB: CNBD6030
LBC: LACBIDRAFT_182694
UMA: UM05984.1
MGL: MGL_1189
MBR: MONBRDRAFT_17767
DDI: DDB_0233691
EDI: EDI_116960
PFA: PF08_0132
PFD: PFDG_00961
PFH: PFHG_02330
PYO: PY03701
PCB: PC000014.03.0
PBE: PB000888.03.0
PKN: PKH_011640
PVX: PVX_093640
TAN: TA11105
TPV: TP04_0883
BBO: BBOV_III009680
TGO: TGME49_049390
TBR: Tb09.160.4310
LMA: LmjF15.1010
LIF: LinJ15.1060
LBZ: LbrM15_V2.1050
PTI: PHATRDRAFT_45239
TPS: THAPSDRAFT_268335
XFA: XF2091
XFT: PD0785(gdhA)
XFM: Xfasm12_0934
XFN: XfasM23_0829
XCC: XCC2365
XCB: XC_1751
XCA: xccb100_1807
XCV: XCV2674
XAC: XAC2496
XOO: XOO2802
XOM: XOO_2642
XOP: PXO_00479
SML: Smlt3167
SMT: Smal_2605
VCH: VC1492
VCO: VC0395_A1099
VCM: VCM66_1435
VCJ: VCD_002882
VVU: VV1_2638 VV1_2639
VVY: VV1652
VPA: VP1602
VHA: VIBHAR_02342
VSP: VS_1421
VEX: VEA_003435
VFI: VF_1284
VFM: VFMJ11_1362
PPR: PBPRA1766
PAE: PA3068(gdhB)
PAU: PA14_24445(gdhB)
PAP: PSPA7_2072
PAG: PLES_19921(gdhB)
PPU: PP_2080
PPF: Pput_3660
PPG: PputGB1_1591
PPW: PputW619_1598
PST: PSPTO_3757
PSB: Psyr_1724
PSP: PSPPH_3560
PFL: PFL_2741
PFO: Pfl01_3206
PFS: PFLU3504
PEN: PSEEN1740(gdhB)
PMY: Pmen_2928
PSA: PST_2393
CJA: CJA_2161
AVN: Avin_18860
PAR: Psyc_1062(gdhA2)
PCR: Pcryo_1400
PRW: PsycPRwf_1098
SON: SO_2593
SDN: Sden_1729
SFR: Sfri_2221
SAZ: Sama_1592
SBL: Sbal_2440
SBM: Shew185_2433
SBN: Sbal195_2553
SBP: Sbal223_1911
SLO: Shew_1809
SPC: Sputcn32_2195
SSE: Ssed_2476
SPL: Spea_1942
SHE: Shewmr4_1680
SHM: Shewmr7_1755
SHN: Shewana3_1785
SHW: Sputw3181_1814
SHL: Shal_2357
SWD: Swoo_2140
SWP: swp_2811
ILO: IL1279
CPS: CPS_2802
PHA: PSHAa1670
PAT: Patl_2002
SDE: Sde_1748
MAQ: Maqu_1944
AMC: MADE_02008
PIN: Ping_0851
TTU: TERTU_2429
CBU: CBU_1226
CBS: COXBURSA331_A1371
CBD: CBUD_1311
CBG: CbuG_0784
CBC: CbuK_1086
LPN: lpg1581
LPF: lpl1444
LPP: lpp1539
LPC: LPC_1006
MCA: MCA1030(gluD) MCA1684
NOC: Noc_2978
AEH: Mlg_2779
HCH: HCH_04777
CSA: Csal_1340
ABO: ABO_1595
MMW: Mmwyl1_1110
AHA: AHA_2288
ASA: ASA_1992
KKO: Kkor_1988
NMA: NMA1687
NME: NMB1476(gluD)
NMC: NMC1413
NMN: NMCC_1388(gluD)
NMI: NMO_1307(gdhA1)
CVI: CV_3084(gdhA)
LHK: LHK_01887(gdhA-2)
RPI: Rpic_4838
RPF: Rpic12D_3761
REU: Reut_A1288
REH: H16_A1356(gudB)
RME: Rmet_1181
CTI: RALTA_A1276
BVI: Bcep1808_5206
BUR: Bcep18194_B1137
BCN: Bcen_3684
BCH: Bcen2424_4683
BCM: Bcenmc03_5617
BCJ: BCAM1822
BAM: Bamb_4077
BAC: BamMC406_4541
BMU: Bmul_4010
BMJ: BMULJ_04494
BXE: Bxe_B0842
BPH: Bphy_4626
BPY: Bphyt_4527
RFR: Rfer_1509
POL: Bpro_3020
PNA: Pnap_2078
LCH: Lcho_2684
EBA: ebA3619(gdh)
TMZ: Tmz1t_1660
APP: CAP2UW1_1097
NAM: NAMH_0845
DVM: DvMF_1346
DDE: Dde_1382
DMA: DMR_20420
DRT: Dret_0171
BBA: Bd0717
DAT: HRM2_03510(gdhA2) HRM2_38410(gdhA3) HRM2_38710(gdhA4)
HOH: Hoch_4376
RCM: A1E_04850
RAK: A1C_05635
RRI: A1G_06460
RRJ: RrIowa_1382
RMS: RMA_1197
RPK: RPR_03130
RAF: RAF_ORF1070
RBO: A1I_00710
OTT: OTT_1868
WRI: WRi_002120
WPI: WPa_0356(gdhB)
AMF: AMF_352(gdh)
ACN: ACIS_00825(gdh)
ERU: Erum3230
ERW: ERWE_CDS_03300
ECN: Ecaj_0306
NRI: NRI_0487
MLO: mll4104
MES: Meso_3422
SME: SMc04085
SMD: Smed_3187
ATU: Atu2766(gdh)
ATC: AGR_C_5015
ARA: Arad_4924
AVI: Avi_4368(gdh)
RET: RHE_CH04105(ypch01447)
REC: RHECIAT_CH0004397
RLE: RL4720(gdhB)
RLT: Rleg2_3913
RLG: Rleg_4237
RHI: NGR_c33260
LAS: CLIBASIA_02745
BME: BMEI0231
BMF: BAB1_1827
BMB: BruAb1_1798
BMC: BAbS19_I17080
BMS: BR1819
BMT: BSUIS_B1297
BOV: BOV_1751
BCS: BCAN_A1857
BMR: BMI_I1835
OAN: Oant_1084
BJA: blr7995
BHE: BH16060
BQU: BQ12960
BBK: BARBAKC583_0066
BTR: Btr_2578
BGR: Bgr_19660
XAU: Xaut_1432
AZC: AZC_4508
MRD: Mrad2831_0077
MET: M446_3670
MNO: Mnod_4521
CCR: CC_0088
CCS: CCNA_00086
CAK: Caul_4787
PZU: PHZ_c3498
MMR: Mmar10_2930
HNE: HNE_3105
HBA: Hbal_2433
NAR: Saro_0211
SWI: Swit_4604
ACR: Acry_1427
RRU: Rru_A3663
RCE: RC1_2702(gdhA)
MAG: amb0031
BSU: BSU22960(gudB) BSU37790(rocG)
BHA: BH1622 BH2718 BH3942
BAN: BA1511(gdhA)
BAR: GBAA1511(gdhA)
BAA: BA_2033
BAT: BAS1401
BAH: BAMEG_3081(gudB)
BAI: BAA_1581(gudB)
BCE: BC1491
BCA: BCE_1617(gdhA)
BCZ: BCZK1372(gdhA)
BCR: BCAH187_A1652(gudB)
BCB: BCB4264_A1546(gudB)
BCU: BCAH820_1585(gudB)
BCG: BCG9842_B3799(gudB)
BCQ: BCQ_1560(gdhA)
BCX: BCA_1550(gudB)
BCY: Bcer98_1214
BTK: BT9727_1373(gdhA)
BTL: BALH_1347(gdhA)
BWE: BcerKBAB4_1413
BLI: BL02226(gudB)
BLD: BLi02435(gudB)
BCL: ABC1862(gudB)
BAY: RBAM_021110(gudB) RBAM_034990(rocG)
BPU: BPUM_2029(gudB)
OIH: OB1810(gudB)
GKA: GK0189 GK2235
GTN: GTNG_2171
GWC: GWCH70_0811 GWCH70_2183
GYC: GYMC61_0445 GYMC61_1045
AFL: Aflv_1068(gudB)
SAU: SA0819(gudB)
SAV: SAV0958(gudB)
SAW: SAHV_0953(gudB)
SAM: MW0840(gudB)
SAR: SAR0920
SAS: SAS0828
SAC: SACOL0961(gluD)
SAB: SAB0825
SAA: SAUSA300_0861(gudB)
SAX: USA300HOU_0917(gudB)
SAO: SAOUHSC_00895
SAJ: SaurJH9_0958
SAH: SaurJH1_0977
SAE: NWMN_0828(gudB)
SAD: SAAV_0919(gluD)
SEP: SE0654
SER: SERP0546(gluD)
SHA: SH1992(gudB)
SSP: SSP1817 SSP2174
SCA: Sca_0566(gudB)
LSP: Bsph_0624
ESI: Exig_1813
EAT: EAT1b_2980
MCL: MCCL_0584(gudB)
BBE: BBR47_24340(gdhA)
PJD: Pjdr2_2378
AAC: Aaci_1313
CTC: CTC01295
CDF: CD0179(gluD)
CDC: CD196_0193(gluD)
CDL: CDR20291_0180(gluD)
CBO: CBO1811(gluD)
CBA: CLB_1746(gluD)
CBH: CLC_1753(gluD)
CBY: CLM_1968(gluD)
CBL: CLK_1192(gluD)
CBB: CLD_2829(gluD)
CBI: CLJ_B1989(gluD)
CBF: CLI_1806(gluD)
AMT: Amet_0815
AOE: Clos_2459
STH: STH1196
FMA: FMG_0889
APR: Apre_0188
TTE: TTE1205(gdhA) TTE1344(gdhA2)
TEX: Teth514_1591
TPD: Teth39_1154
CPO: COPRO5265_0158
NTH: Nther_1485
MTU: Rv2476c(gdh)
MTC: MT2551
MRA: MRA_2501(gdh)
MTF: TBFG_12500
MTB: TBMG_01497(TBMG_01497.1)
MBO: Mb2503c(gdh)
MBB: BCG_2496c(gdh)
MBT: JTY_2490(gdh)
MLB: MLBr_01249
MAV: MAV_1696
MSM: MSMEG_4699
MGI: Mflv_2569
MAB: MAB_1561
MMC: Mmcs_3614
MKM: Mkms_3687
MJL: Mjls_3619
MMI: MMAR_3829(gdh)
RER: RER_38310(gdh)
ROP: ROP_11070(gdh)
GBR: Gbro_2027
SCO: SCO2999(SCE33.01c)
SMA: SAV_5075
SGR: SGR_4536
ART: Arth_2699
ACH: Achl_2430
RSA: RSal33209_1623
KRH: KRH_20080(gdh)
BCV: Bcav_1575
KSE: Ksed_08770
NCA: Noca_1225
TFU: Tfu_2481
TCU: Tcur_4011
SRO: Sros_1449
FAL: FRAAL0156
ACE: Acel_1749
NML: Namu_1819
KRA: Krad_3797
SEN: SACE_1325(gudB) SACE_4093(gudB)
SVI: Svir_11780
AMI: Amir_1129
STP: Strop_3605
SAQ: Sare_3986
CAI: Caci_7895
RXY: Rxyl_2529
AFO: Afer_0272
FNU: FN0488
LBA: Lebu_2184
MPD: MCP_0793
HMA: rrnAC0884
NPH: NP6184A(gdhA_3)
PCL: Pcal_1031
 |
|---|
| Structures |
PDB: 1AUP 1BGV 1EUZ 1HRD 1K89 1V9L |
|---|
Reference
Authors
Title
Journal
|
1
Frieden, C.
L-Glutamate dehydrogenase.
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd
ed., vol. 7, Academic Press, New York, 1963, p. 3-24. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:13140081]
NISMAN B.
The Stickland reaction.
Bacteriol. Rev. 18 (1954) 16-42.
Clostridium sporogenes, Clostridium saccharobutyricum |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:4324282]
Pahlich E, Joy KW.
Glutamate dehydrogenase from pea roots: purification and properties
of the enzyme.
Can. J. Biochem. 49 (1971) 127-38.
Pisum sativum |
|---|
Reference
Authors
Title
Journal
|
4
Smith, E.L., Austen, B.M., Blumenthal, K.M. and Nyc, J.F.
Glutamate dehydrogenases.
In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 11, Academic
Press, New York, 1975, p. 293-367. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.4.1.2
IUBMB Enzyme Nomenclature: 1.4.1.2
ExPASy - ENZYME nomenclature database: 1.4.1.2
BRENDA, the Enzyme Database: 1.4.1.2
CAS: 9001-46-1 |
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