| Entry |
|
|---|
| Name |
phenylalanine dehydrogenase;
L-phenylalanine dehydrogenase;
PHD |
|---|
| Class |
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
L-phenylalanine:NAD+ oxidoreductase (deaminating) |
|---|
| Reaction(IUBMB) |
L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH + H+
[RN:R00688] |
|---|
| Reaction(KEGG) |
R00688;
(other) R00145 R00146
 |
|---|
| Substrate |
L-phenylalanine [CPD:C00079];
H2O [CPD:C00001];
NAD+ [CPD:C00003] |
|---|
| Product |
phenylpyruvate [CPD:C00166];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080] |
|---|
| Comment |
The enzymes from Bacillus badius and Sporosarcina ureae are highly
specific for L-phenylalanine; that from Bacillus sphaericus also
acts on L-tyrosine. |
|---|
| Pathway |
PATH: ec00360 Phenylalanine metabolism
PATH: ec00400 Phenylalanine, tyrosine and tryptophan biosynthesis
PATH: ec01061 Biosynthesis of phenylpropanoids
PATH: ec01064 Biosynthesis of alkaloids derived from ornithine,
lysine and nicotinic acid
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00270 phenylalanine dehydrogenase |
|---|
| Genes |
BHA: BH0218(pdh)
OIH: OB2878
GKA: GK2031(pdh)
GTN: GTNG_1916
ESI: Exig_0386
 |
|---|
| Structures |
PDB: 1BW9 1BXG |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:3112142]
Asano Y, Nakazawa A, Endo K.
Novel phenylalanine dehydrogenases from Sporosarcina ureae and
Bacillus sphaericus. Purification and characterization.
J. Biol. Chem. 262 (1987) 10346-54.
Sporosarcina ureae, Bacillus sphaericus |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:3311741]
Asano Y, Nakazawa A, Endo K, Hibino Y, Ohmori M, Numao N, Kondo K.
Phenylalanine dehydrogenase of Bacillus badius. Purification,
characterization and gene cloning.
Eur. J. Biochem. 168 (1987) 153-9.
Bacillus badius |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.4.1.20
IUBMB Enzyme Nomenclature: 1.4.1.20
ExPASy - ENZYME nomenclature database: 1.4.1.20
BRENDA, the Enzyme Database: 1.4.1.20
CAS: 69403-12-9 |
|---|
