KEGG   ENZYME: 1.4.1.3Help
Entry
EC 1.4.1.3                  Enzyme                                 
Name glutamate dehydrogenase [NAD(P)+];
glutamic dehydrogenase;
glutamate dehydrogenase [NAD(P)+]
Class Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname L-glutamate:NAD(P)+ oxidoreductase (deaminating)
Reaction(IUBMB) L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+
[RN:R00243 R00248]
Reaction(KEGG) R00243 R00248;
(other) R00145 R00146
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Substrate L-glutamate [CPD:C00025];
H2O [CPD:C00001];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product 2-oxoglutarate [CPD:C00026];
NH3 [CPD:C00014];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Pathway PATH: ec00250  Alanine, aspartate and glutamate metabolism
PATH: ec00330  Arginine and proline metabolism
PATH: ec00471  D-Glutamine and D-glutamate metabolism
PATH: ec00910  Nitrogen metabolism
PATH: ec01064  Biosynthesis of alkaloids derived from ornithine,
               lysine and nicotinic acid
PATH: ec01100  Metabolic pathways
Orthology KO: K00261  glutamate dehydrogenase (NAD(P)+)
Genes HSA: 2746(GLUD1) 2747(GLUD2)
PTR: 449581(GLUD2) 450576(GLUD1)
MCC: 702427
MMU: 14661(Glud1)
RNO: 24399(Glud1)
CFA: 483859(GLUD1)
BTA: 281785(GLUD1)
ECB: 100064139
MDO: 100020220
OAA: 100076659
GGA: 423612(GLUD1)
TGU: 100222270
XLA: 446858(glud1)
XTR: 496554(glud1)
DRE: 317737(glud1a) 373092(glud1b)
BFO: BRAFLDRAFT_130686
CIN: 100177733
SPU: 584300
DME: Dmel_CG4434 Dmel_CG5320(Gdh)
DPO: Dpse_GA18802
DAN: Dana_GF17976 Dana_GF18014
DER: Dere_GG12388 Dere_GG12444
DPE: Dper_GL23033 Dper_GL24163
DSE: Dsec_GM23525 Dsec_GM23576
DSI: Dsim_GD18335 Dsim_GD18391
DYA: Dyak_GE10843 Dyak_GE23967
DGR: Dgri_GH19680 Dgri_GH20746
DMO: Dmoj_GI22276 Dmoj_GI23212
AGA: AgaP_AGAP004362 AgaP_AGAP004622
AAG: AaeL_AAEL003757 AaeL_AAEL010464
CQU: CpipJ_CPIJ008658 CpipJ_CPIJ014605
AME: 409253
NVI: 100123602
TCA: 657380
API: 100169613
ISC: IscW_ISCW000393
CEL: ZK829.4
CBR: CBG06199
BMY: Bm1_08210
SMM: Smp_093820
NVE: NEMVE_v1g169502 NEMVE_v1g243194
HMG: 100210563
TAD: TRIADDRAFT_36699
ATH: AT3G03910(GDH3) AT5G07440(GDH2) AT5G18170(GDH1)
POP: POPTR_571209 POPTR_575509 POPTR_826140 POPTR_828764
RCU: RCOM_1121650 RCOM_1502760
VVI: 100250450(GSVIVT00025474001) 100257914(GSVIVT00014104001)
OSA: 4330164(Os02g0650900) 4334405(Os03g0794500)
     4336554(Os04g0543900)
SBI: SORBI_06g024150(SORBIDRAFT_06g024150)
ZMA: 100193614 542220(gdh1)
PPP: PHYPADRAFT_126976 PHYPADRAFT_190253
CRE: CHLREDRAFT_82916(GDH2)
CME: CML049C
MBR: MONBRDRAFT_33746
DDI: DDB_0231438
TET: TTHERM_00787250 TTHERM_01048110 TTHERM_01049200
PTM: GSPATT00012182001 GSPATT00031334001
STY: STY1922(gdhA)
STT: t1082(gdhA)
SPT: SPA1078
SEK: SSPA1006
SPQ: SPAB_01425
SEI: SPC_1935
SEC: SC1788(gdh)
SEH: SeHA_C1992
SEE: SNSL254_A1932
SEW: SeSA_A1936
SEA: SeAg_B1339
SED: SeD_A1524
SEG: SG1321
SET: SEN1242
SES: SARI_01144
STM: STM1795
ETA: ETA_17440(gdhA)
SGL: SG0175
KPN: KPN_01492
KPE: KPK_2969
KPU: KP1_2495
SPE: Spro_2473
DDA: Dd703_1230
ACI: ACIAD2680(gdh)
ACB: A1S_3134
ABM: ABSDF0354(gdh)
ABY: ABAYE0351(gdh)
ABC: ACICU_03335
ABN: AB57_3588
ABB: ABBFA_000376
TCX: Tcr_1836
NOC: Noc_2054
TGR: Tgr7_1853
NGK: NGK_0734
RSO: RSc0480(gdhA)
RPI: Rpic_0356
RPF: Rpic12D_0371
REU: Reut_A0456
REH: H16_A0471(gdhA1)
RME: Rmet_0398
CTI: RALTA_A0427(gdhA2)
BMA: BMA2439(gdhA)
BMV: BMASAVP1_A0353(gdhA)
BML: BMA10229_A1212(gdhA)
BMN: BMA10247_2623(gdhA)
BPS: BPSL2925
BPM: BURPS1710b_3435(gdhA)
BPL: BURPS1106A_3432
BPD: BURPS668_3397
BPR: GBP346_A3577
BTE: BTH_I1224
BVI: Bcep1808_0634
BUR: Bcep18194_A3754
BCN: Bcen_0185
BCH: Bcen2424_0668
BCM: Bcenmc03_0635
BCJ: BCAL3359
BAM: Bamb_0563
BAC: BamMC406_0589
BMU: Bmul_2715
BMJ: BMULJ_00522
BXE: Bxe_A0596
BPH: Bphy_2574
BPY: Bphyt_3363
BGL: bglu_1g05580
BPE: BP1857(gdhA)
BPA: BPP1568(gdhA)
BBR: BB2646(gdhA)
BPT: Bpet2493(gdhA2)
BAV: BAV1836(gdhA)
POL: Bpro_3239
PNA: Pnap_1441
AAV: Aave_0188
AJS: Ajs_0135
VEI: Veis_1702
DAC: Daci_0211
DIA: Dtpsy_0153
VAP: Vapar_4808
CTT: CtCNB1_0120
MPT: Mpe_A3745
MMS: mma_0278(gdhA1)
LCH: Lcho_1626
DAR: Daro_2721
TMZ: Tmz1t_1333
CFF: CFF8240_1557
GUR: Gura_2895
GEM: GM21_0478
PCA: Pcar_1237
PPD: Ppro_1713
DPS: DP1198
ADE: Adeh_1766
ACP: A2cp1_2166
AFW: Anae109_2052
ANK: AnaeK_2074
MXA: MXAN_5873(gdhA)
SCL: sce4305(gdhA1) sce6195(gdhA2)
HOH: Hoch_2255 Hoch_4067
SAT: SYN_01242
SFU: Sfum_3244 Sfum_3265
PUB: SAR11_1187(gdhA)
PLA: Plav_1121
RLE: pRL100054
RHI: NGR_a01340
OAN: Oant_4595
BRA: BRADO2494(gdh)
BBT: BBta_2839(gdh)
NWI: Nwi_2286
NHA: Nham_2702
MNO: Mnod_0895
PZU: PHZ_c2434
SIL: SPO1743
SIT: TM1040_2150
RSP: RSP_0398
RSH: Rsph17029_2051
RSQ: Rsph17025_0839
RSK: RSKD131_1727
JAN: Jann_3440
RDE: RD1_1787(gilL)
BHA: BH0824
BBE: BBR47_08520(gdhA)
SWO: Swol_2170
VPR: Vpar_1550
DAE: Dtox_3997
CGT: cgR_2827
CEF: CE1577
RHA: RHA1_ro00339(gdhA1) RHA1_ro00573(dghA) RHA1_ro03043(gdhA2)
     RHA1_ro03288 RHA1_ro08786(gdhA3)
ROP: ROP_04820 ROP_27680 ROP_28450 ROP_30130 ROP_53310
SMA: SAV_1636(rocG)
SGR: SGR_3482
MLU: Mlut_00880
KSE: Ksed_04360
XCE: Xcel_2621
SRO: Sros_2327
FRA: Francci3_4390
FRE: Franean1_0183
FAL: FRAAL6693(gdhA)
SEN: SACE_3873(dghA) SACE_3882(gdhA1)
SVI: Svir_22490
SAQ: Sare_2957
TDE: TDE0997(gdhA)
ABA: Acid345_4115
ACA: ACP_2883(gdhA)
SRU: SRU_0505(gdhA)
RMR: Rmar_2129
DFE: Dfer_3400
CPI: Cpin_1525
PHE: Phep_3219
GFO: GFO_0726(gdhA)
RBI: RB2501_10817
BBL: BLBBGE_121(gdhA)
BPI: BPLAN_514(gdhA)
AAS: Aasi_0113
OTE: Oter_3619
MIN: Minf_1762(gdhA)
GAU: GAU_1594(gdhA)
RBA: RB6930(gdhA)
TAI: Taci_0188 Taci_0319
NPU: Npun_F3641
CTE: CT2023(gdhA)
CPC: Cpar_1901
CPH: Cpha266_0167
CLI: Clim_0179
CTS: Ctha_0350
RRS: RoseRS_1722 RoseRS_4385
RCA: Rcas_0724 Rcas_2006
CAU: Caur_1698 Caur_2070
CAG: Cagg_1389 Cagg_2689
CHL: Chy400_1839 Chy400_2231
HAU: Haur_4511
TRO: trd_1476
STI: Sthe_1648 Sthe_1942
DRA: DR_0980
DGE: Dgeo_0494 Dgeo_0495
DDR: Deide_18260(gdhA) Deide_18270(gdhA)
TTH: TTC1211 TTC1212
TTJ: TTHA1576 TTHA1577
SAF: SULAZ_1457
TMA: TM1015
TPT: Tpet_1731
TLE: Tlet_0263
TRQ: TRQ2_1790
TNA: CTN_1563
TNP: Tnap_1745
TME: Tmel_0305 Tmel_0603
TAF: THA_550
FNO: Fnod_1064
PMO: Pmob_1583
KOL: Kole_0297 Kole_1402
TTR: Tter_0805
MAC: MA3169(gdhA)
MBA: Mbar_A2938
MMA: MM_0357 MM_3297
MBU: Mbur_1973
MLA: Mlab_0706
HAL: VNG0161G(gdhB) VNG0628G(gdhA1) VNG1204G(gdhA2)
HSL: OE1270F(gdhA3) OE1943F(gdhA1) OE2728R(gdhA2)
HMA: pNG7157(gudB) rrnAC0384(gdhA1) rrnAC0775(gdhA2)
NPH: NP1806A(gdhA_1)
HLA: Hlac_0802 Hlac_1201
HUT: Huta_0589
HMU: Hmuk_3114 Hmuk_3134 Hmuk_3380
TAC: Ta0635 Ta0776
TVO: TVN0759 TVN0760
PTO: PTO1315
PHO: PH1593
PAB: PAB0391(gdh)
PFU: PF1602
TKO: TK1431
TON: TON_0157
TGA: TGAM_1823(ghd-2)
TSI: TSIB_1110
RCI: LRC421(gdh-1) LRC422(gdh-2)
APE: APE_1386.1
SMR: Smar_0497
DKA: DKAM_1451
HBU: Hbut_0861
SSO: SSO1457(gdhA-1) SSO1907(gdhA-2) SSO1930(gdhA-3) SSO2044(gdhA-4)
STO: ST2241
SAI: Saci_0155(gdhA)
SIS: LS215_0926
SIA: M1425_0701 M1425_0949
SIM: M1627_0705 M1627_1005
SID: M164_0729 M164_0954
SIY: YG5714_0687 YG5714_0997
SIN: YN1551_1875 YN1551_2473
MSE: Msed_2074
PAI: PAE1996 PAE3438
PIS: Pisl_0980 Pisl_1816
PAS: Pars_1871
CMA: Cmaq_0204
TNE: Tneu_1301
TPE: Tpen_0843
NMR: Nmar_1312
NEQ: NEQ077
KCR: Kcr_0087
Taxonomy
Structures PDB: 1B26  1B3B  1BVU  1GTM  1HWX  1HWY  1HWZ  1L1F  1NQT  1NR1  
     1NR7  2TMG  3ETE  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:12981035]
OLSON JA, ANFINSEN CB.
The crystallization and characterization of L-glutamic acid
dehydrogenase.
J. Biol. Chem. 197 (1952) 67-79.
Bos taurus [GN:bta]
Reference
  Authors
  Title
  Journal

 2
Smith, E.L., Austen, B.M., Blumenthal, K.M. and Nyc, J.F.
Glutamate dehydrogenases.
In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 11, Academic
Press, New York, 1975, p. 293-367.
Reference
  Authors
  Title
  Journal
  Organism
 3  [PMID:13092953]
STRECKER HJ.
Glutamic dehydrogenase.
Arch. Biochem. Biophys. 46 (1953) 128-40.
Bos taurus [GN:bta]
Other DBs ExplorEnz - The Enzyme Database: 1.4.1.3
IUBMB Enzyme Nomenclature: 1.4.1.3
ExPASy - ENZYME nomenclature database: 1.4.1.3
BRENDA, the Enzyme Database: 1.4.1.3
CAS: 9029-12-3
DBGET integrated database retrieval system