| Entry |
|
|---|
| Name |
glutamate dehydrogenase (NADP+);
glutamic dehydrogenase;
dehydrogenase, glutamate (nicotinamide adenine dinucleotide
(phosphate));
glutamic acid dehydrogenase;
L-glutamate dehydrogenase;
L-glutamic acid dehydrogenase;
NAD(P)+-glutamate dehydrogenase;
NAD(P)H-dependent glutamate dehydrogenase;
glutamate dehydrogenase (NADP+) |
|---|
| Class |
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
L-glutamate:NADP+ oxidoreductase (deaminating) |
|---|
| Reaction(IUBMB) |
L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+
[RN:R00248] |
|---|
| Reaction(KEGG) |
R00248;
(other) R00145 R00146
 |
|---|
| Substrate |
L-glutamate [CPD:C00025];
H2O [CPD:C00001];
NADP+ [CPD:C00006] |
|---|
| Product |
2-oxoglutarate [CPD:C00026];
NH3 [CPD:C00014];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Pathway |
PATH: ec00250 Alanine, aspartate and glutamate metabolism
PATH: ec00330 Arginine and proline metabolism
PATH: ec00910 Nitrogen metabolism
PATH: ec01064 Biosynthesis of alkaloids derived from ornithine,
lysine and nicotinic acid
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00262 glutamate dehydrogenase (NADP+) |
|---|
| Genes |
CIN: 100176644
ATH: AT1G51720
POP: POPTR_924051
RCU: RCOM_1485390
VVI: 100244689
OSA: 4324672(Os01g0558200)
SBI: SORBI_03g025320(SORBIDRAFT_03g025320)
PPP: PHYPADRAFT_179243 PHYPADRAFT_70453
CME: CMM119C
SCE: YAL062W(GDH3) YOR375C(GDH1)
KLA: KLLA0F00594g
LTH: KLTH0D00550g
DHA: DEHA0C18480g
PIC: PICST_82969(GDH3)
PPA: PAS_chr1-1_0107
VPO: Kpol_538p50
LEL: LELG_04591
ZRO: ZYRO0C00396g
CAL: CaO19.4716(GDH1)
CTP: CTRG_04035
CDU: CD36_45660
CGR: CAGL0D00176g
YLI: YALI0F17820g
SPO: SPCC622.12c
NCR: NCU01195
PAN: PODANSg8412
MGR: MGG_08074
FGR: FG07174.1
ANI: AN4376.2
AFM: AFUA_4G06620
AOR: AO090023000923
ANG: An04g00990(gdhA)
AFV: AFLA_113320
PCS: Pc22g17560(gdhA)
NFI: NFIA_109570
CIM: CIMG_04095
URE: UREG_06801
SSL: SS1G_09120
BFU: BC1G_13490
CNE: CNC00920
CNB: CNBC6340
LBC: LACBIDRAFT_292653
MPR: MPER_04103
UMA: UM02801.1
PFA: PF14_0164 PF14_0286
PFD: PFDG_00557 PFDG_00941
PFH: PFHG_00498 PFHG_03316
PYO: PY04261
PCB: PC000581.03.0 PC000975.01.0
PBE: PB000714.01.0 PB300230.00.0
PKN: PKH_131960 PKH_133070
PVX: PVX_085005 PVX_085625
BBO: BBOV_IV010390
TGO: TGME49_093180
TCR: 507875.20 508111.30
LMA: LmjF28.2910
LIF: LinJ28.3060
LBZ: LbrM28_V2.3120
TVA: TVAG_025910 TVAG_196700
TPS: THAPSDRAFT_38359(GDH_1)
ECO: b1761(gdhA)
ECJ: JW1750(gdhA)
ECD: ECDH10B_1899(gdhA)
EBW: BWG_1574(gdhA)
ECE: Z2793(gdhA)
ECS: ECs2467
ECF: ECH74115_2481(gdhA)
ETW: ECSP_2329(gdhA)
ECG: E2348C_1889(gdhA)
ECC: c2162(gdhA)
ECI: UTI89_C1957(gdhA)
ECP: ECP_1707
ECV: APECO1_831(gdhA)
ECW: EcE24377A_1984(gdhA)
ECX: EcHS_A1845(gdhA)
ECM: EcSMS35_1429(gdhA)
ECY: ECSE_1932
ECL: EcolC_1871
ECK: EC55989_1928(gdhA)
ECQ: ECED1_1962(gdhA)
ECR: ECIAI1_1822(gdhA)
ECT: ECIAI39_1294(gdhA)
ECZ: ECS88_1812(gdhA)
EUM: ECUMN_2049(gdhA)
ELF: LF82_0823(gdhA)
EBL: B21_01718(gdhA)
EBD: ECBD_1883
EBR: ECB_01730(gdhA)
EOH: ECO103_1954(gdhA)
EOI: ECO111_2272(gdhA)
EOJ: ECO26_2536(gdhA)
EFE: EFER_1304(gdhA)
STY: STY1815(gdhA)
STT: t1178(gdhA)
SPT: SPA1545(gdhA)
SEK: SSPA1436
SPQ: SPAB_02044
SEI: SPC_2433(gdhA)
SEC: SC1321(gdhA)
SEH: SeHA_C1426(gdhA)
SEE: SNSL254_A1410(gdhA)
SEW: SeSA_A1393(gdhA)
SEA: SeAg_B1876(gdhA)
SED: SeD_A2047(gdhA)
SET: SEN1744(gdhA)
SES: SARI_01680
STM: STM1299(gdhA)
YPE: YPO3971(gdhA)
YPK: y3858(gdhA)
YPM: YP_3334(gdhA)
YPA: YPA_3799
YPN: YPN_3620
YPG: YpAngola_A4089(gdhA)
YPP: YPDSF_3336
YPS: YPTB3813(gdhA)
YPI: YpsIP31758_4036(gdhA)
YPY: YPK_0119
YPB: YPTS_4027
YEN: YE4051(gdhA)
SFL: SF1462(gdhA)
SFV: SFV_1457(gdhA)
SSN: SSON_1395(gdhA)
SBO: SBO_1328(gdhA)
SBC: SbBS512_E2014(gdhA)
SDY: SDY_1514(gdhA)
ECA: ECA0051(gdhA)
PCT: PC1_4200
PWA: Pecwa_4483
PLU: plu0122(gdhA)
PAY: PAU_00106(gdhA)
ENT: Ent638_1685
KPN: KPN_01210(gdhA)
KPE: KPK_3234(gdhA)
KPU: KP1_2238(gdhA)
CKO: CKO_01789
SPE: Spro_4692
PMR: PMI3008(gdhA)
EIC: NT01EI_3732
ETR: ETAE_3353
HIN: HI0189(gdhA)
HIT: NTHI0283(gdhA)
HIP: CGSHiEE_02310
HSO: HS_1339(gdhA)
HSM: HSM_0283
PMU: PM0043(gdhA)
MSU: MS0196(gdhA)
APL: APL_0427(gdhA)
APJ: APJL_0452(gdhA)
APA: APP7_0451
ASU: Asuc_0375
AAP: NT05HA_0070
AAT: D11S_2120
VEX: VEA_000352
PAE: PA4588(gdhA)
PAU: PA14_60710(gdhA)
PAP: PSPA7_5228(gdhA)
PAG: PLES_49711(gdhA)
PPU: PP_0675(gdhA)
PPF: Pput_0706
PPG: PputGB1_0707
PPW: PputW619_4509
PFL: PFL_5343(gdhA)
PFO: Pfl01_4874
PFS: PFLU5326(gdhA)
PEN: PSEEN0812(gdhA)
PMY: Pmen_1771
PSA: PST_0934(gdhA)
CJA: CJA_2152(gdhA)
PAR: Psyc_1670(dhe4)
PCR: Pcryo_1935
PRW: PsycPRwf_1144
ACI: ACIAD1110(gdhA)
ACB: A1S_1026
ABM: ABSDF2361(gdhA)
ABY: ABAYE2764(gdhA)
ABC: ACICU_00988
ABN: AB57_1107
ABB: ABBFA_002583
SPL: Spea_0527
SHL: Shal_0590
ILO: IL2338(gdhA)
PHA: PSHAa1392(gdhA)
PAT: Patl_0286
MAQ: Maqu_0302
AMC: MADE_01682 MADE_02946
LPP: lpp2344(gdhA)
FTU: FTT_0380c(gdh)
FTF: FTF0380c(gdh)
FTW: FTW_0766
FTL: FTL_0269
FTH: FTH_0268
FTA: FTA_0286
FTM: FTM_1499(gdhA)
FTN: FTN_1532(gdhA)
FPH: Fphi_1107
NOC: Noc_0864
AEH: Mlg_2123
HHA: Hhal_0060
ABO: ABO_2099(gdhA) ABO_2100(gdhA)
MMW: Mmwyl1_1895
AHA: AHA_1626
ASA: ASA_2731(gdhA)
KKO: Kkor_2077
NMA: NMA1964(gdhA)
NME: NMB1710(gdhA)
NMC: NMC1625(gdhA)
NMN: NMCC_1621(gdhA)
NMI: NMO_1524(gdhA3)
NGO: NGO1358
NGK: NGK_1591
LHK: LHK_01886(gdhA-1)
REU: Reut_B3724
REH: H16_B1945(gdhA2)
RME: Rmet_5114
CTI: RALTA_B1640(gdhA1)
BPE: BP0368(gdhA)
BBR: BB4535(gdhA)
BPT: Bpet0421(gdhA1)
BAV: BAV3182(gdhA)
AJS: Ajs_0977
DAC: Daci_5140
DIA: Dtpsy_0892 Dtpsy_1459
CTT: CtCNB1_1102
HAR: HEAR0384(gdhA)
MMS: mma_1454(gdhA2)
NEU: NE1616(gdhA)
NET: Neut_0501
NMU: Nmul_A2447
EBA: ebA5425(gdhA)
TMZ: Tmz1t_0452
MFA: Mfla_1286
HPY: HP0380
HPJ: jhp1001(gdhA)
HPA: HPAG1_1012
HPS: HPSH_05515
HPG: HPG27_1017
HPP: HPP12_1041(gdhA)
HPB: HELPY_1045(gdhA)
HHE: HH1241(gdhA)
HAC: Hac_0475(gdhA)
WSU: WS1924(gdhA)
TDN: Suden_1510
CCV: CCV52592_0886
CHA: CHAB381_0345
CCO: CCC13826_1815
CLA: Cla_1290(gdhA)
ABU: Abu_0287(gdhA)
SDL: Sdel_2189
SUN: SUN_1928(gdhA)
GSU: GSU1305
GME: Gmet_1186
GUR: Gura_2800
GLO: Glov_0573
GBM: Gbem_0193
GEO: Geob_2399
GEM: GM21_0175
PPD: Ppro_3497
DDS: Ddes_1152
DSA: Desal_1512
DBA: Dbac_3443
DPS: DP2840
DOL: Dole_1647
DAT: HRM2_03260(gdhA1)
ADE: Adeh_3019
ACP: A2cp1_3219
AFW: Anae109_3000
ANK: AnaeK_3118
SCL: sce9109(gdhA3)
HOH: Hoch_0109
SAT: SYN_02382
SME: SMa0228(gdhA)
BME: BMEI1723
BMF: BAB1_0228
BMB: BruAb1_0222
BMC: BAbS19_I02150
BMS: BR0227
BMT: BSUIS_A0227(gdhA)
BOV: BOV_0218
BCS: BCAN_A0230(gdhA)
BMR: BMI_I230
OAN: Oant_0300
NHA: Nham_0996
OCA: OCAR_7049
MDI: METDI4483(gdhA)
MCH: Mchl_5459
PZU: PHZ_c2888(gdhA)
RDE: RD1_2450(gdhA)
PDE: Pden_3872
DSH: Dshi_3841
NAR: Saro_1272
SAL: Sala_2771
SWI: Swit_0418 Swit_1330 Swit_5321
ELI: ELI_03570
BHA: BH2101(gdhA)
BLI: BL00756(rocG)
BLD: BLi02964(rocG)
BCL: ABC3392
BPU: BPUM_3511(gdhA)
GTN: GTNG_3148
GYM: GYMC10_4994
LMO: lmo0560
LMF: LMOf2365_0589(gdhA)
LMH: LMHCC_2071
LMC: Lm4b_00586
LIN: lin0569
LWE: lwe0526(gdhA)
LSP: Bsph_2152
PJD: Pjdr2_1708
SPN: SP_1306
SPD: SPD_1158(gdhA)
SPR: spr1181(gdhA)
SPW: SPCG_1272(gdhA)
SPX: SPG_1197(gdhA)
SNE: SPN23F_11970(gdh)
SPV: SPH_1446
SNM: SP70585_1369
SJJ: SPJ_1219
SPP: SPP_1344
SNT: SPT_0923
SAG: SAG1335(gdhA)
SAN: gbs1405
SAK: SAK_1366(gdhA)
SMU: SMU.913
STC: str0430(gdhA)
STL: stu0430(gdhA)
STE: STER_0467
SSA: SSA_0371(gdhA)
SSU: SSU05_0252
SSV: SSU98_0248
SSB: SSUBM407_0225(gdh)
SSI: SSU0234(gdh)
SSS: SSUSC84_0223(gdh)
SGO: SGO_0276(gdhA)
SEQ: SZO_08780
SEZ: Sez_1090(gdh)
SEU: SEQ_1280
SUB: SUB0762(gdh)
SDS: SDEG_0823(gdh)
LPL: lp_1169(gdh)
LPJ: JDM1_1013(gdh)
LSL: LSL_1297(gdhA)
LCB: LCABL_06940(gdh)
LRH: LGG_00607(gdh)
LRL: LC705_00586(gdh)
EFA: EF1415(gdhA)
CAC: CAC0737
CPE: CPE1518(gdhA)
CPF: CPF_1770(gdhA)
CPR: CPR_1499
CNO: NT01CX_0097
CTH: Cthe_0374
CBK: CLL_A0779(gluD)
CBT: CLH_0745(gluD)
CKL: CKL_3050(gdh)
CKR: CKR_2695
CPY: Cphy_0826
CCE: Ccel_2430
DSY: DSY4953
DHD: Dhaf_4852
PTH: PTH_0050(gdhA)
EEL: EUBELI_01617
ERE: EUBREC_3138
ACL: ACL_1093
MSM: MSMEG_5442
MVA: Mvan_4804
MGI: Mflv_1929
MAB: MAB_3800c
MMC: Mmcs_4267
MKM: Mkms_4353
MJL: Mjls_4646
CGL: NCgl1999(cgl2079)
CGB: cg2280(gdh)
CGT: cgR_1964
CEF: CE1982(gdh)
CDI: DIP1547(gdh)
CJK: jk1192(gdh)
CUR: cur_0800
CAR: cauri_1607(gdh)
CKP: ckrop_0600
NFA: nfa45920
RHA: RHA1_ro01405(gdh)
RER: RER_38460(gdhA)
ROP: ROP_11170(gdhA)
GBR: Gbro_4667
SCO: SCO4683(gdhA)
SGR: SGR_2604
LXX: Lxx11950(gdhA)
ART: Arth_3505
AAU: AAur_3325(gdhA)
ACH: Achl_3577
KRH: KRH_04830(gdhA)
MLU: Mlut_04440
BCV: Bcav_0346
BFA: Bfae_30790
JDE: Jden_2359
KSE: Ksed_14650
XCE: Xcel_2296
PAC: PPA1513
NCA: Noca_1658
TFU: Tfu_1371
TCU: Tcur_0396
SRO: Sros_5524
SEN: SACE_5979(gdh)
SVI: Svir_32600
BLO: BL0630(gdhA)
BLJ: BLD_1427(gdhA)
BLN: Blon_0011
BAD: BAD_0008(gdhA)
BLA: BLA_0010(gdhA)
BLC: Balac_0010
BLT: Balat_0010
CCU: Ccur_07080
SHI: Shel_10490
APV: Apar_0610
ELE: Elen_1801
BHY: BHWA1_00140
ABA: Acid345_0942
SUS: Acid_0039
BTH: BT_1970 BT_1973
BFR: BF3607 BF3635
BFS: BF3409(gdhB2) BF3437(gdhB)
BVU: BVU_0246 BVU_0251
PGI: PG1232(gdh)
PGN: PGN_1367
PDI: BDI_3804 BDI_3809
DFE: Dfer_2214
PHE: Phep_1212
GFO: GFO_3186(gdhA)
FJO: Fjoh_0708
FPS: FP0271(gdhA)
FBA: FIC_00024
COC: Coch_0726
RBI: RB2501_07780
FSU: Fisuc_2811
STR: Sterm_0271
OTE: Oter_0818
AMU: Amuc_2051
EMI: Emin_0527
SYN: slr0710(gdhA)
SYP: SYNPCC7002_A0773(gdhA)
MAR: MAE_08260(gdhA)
CYT: cce_0997(gdhA)
CYP: PCC8801_0750
CYC: PCC7424_1597
CYN: Cyan7425_4908
CYH: Cyan8802_0779
GVI: gvip150(gdhA)
ANA: alr4255
AVA: Ava_1204 Ava_4115
PMT: PMT0623(gdhA)
PMF: P9303_16151(gdhA)
TER: Tery_4311
AMR: AM1_3244(gdhA)
PAA: Paes_1457
DRA: DR_1718
PMO: Pmob_1813
MVN: Mevan_1556
MST: Msp_1416(gdhA)
MSI: Msm_0888
HWA: HQ1880A(gdhA)
NPH: NP1582A(gdhA_2)
PCL: Pcal_1606
PAS: Pars_2065
 |
|---|
| Structures |
PDB: 2BMA |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4144743]
Coulton JW, Kapoor M.
Purification and some properties of the glutamate dehydrogenase of
Salmonella typhimurium.
Can. J. Microbiol. 19 (1973) 427-38.
Salmonella typhimurium |
|---|
Reference
Authors
Title
Journal
|
2
Grisolia, S., Quijada, C.L. and Fernandez, M.
Glutamate dehydrogenase from yeast and from animal tissues.
Biochim. Biophys. Acta 81 (1964) 61-70. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:4394939]
Shiio I, Ozaki H.
Regulation of nicotinamide adenine dinucleotide phosphate-specific
glutamate dehydrogenase from Brevibacterium flavum, a
glutamate-producing bacterium.
J. Biochem. (Tokyo). 68 (1970) 633-47.
Brevibacterium flavum |
|---|
Reference
Authors
Title
Journal
|
4
Smith, E.L., Austen, B.M., Blumenthal, K.M. and Nyc, J.F.
Glutamate dehydrogenases.
In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 11, Academic
Press, New York, 1975, p. 293-367. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.4.1.4
IUBMB Enzyme Nomenclature: 1.4.1.4
ExPASy - ENZYME nomenclature database: 1.4.1.4
BRENDA, the Enzyme Database: 1.4.1.4
CAS: 9029-11-2 |
|---|
