KEGG   ENZYME: 1.4.1.9Help
Entry
EC 1.4.1.9                  Enzyme                                 
Name leucine dehydrogenase;
L-leucine dehydrogenase;
L-leucine:NAD+ oxidoreductase, deaminating;
LeuDH
Class Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname L-leucine:NAD+ oxidoreductase (deaminating)
Reaction(IUBMB) L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH + H+
[RN:R01088]
Reaction(KEGG) R01088;
(other) R00145 R00146 R01434 R02196 R03960
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Substrate L-leucine [CPD:C00123];
H2O [CPD:C00001];
NAD+ [CPD:C00003]
Product 4-methyl-2-oxopentanoate [CPD:C00233];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment Also acts on isoleucine, valine, norvaline and norleucine.
Pathway PATH: ec00280  Valine, leucine and isoleucine degradation
PATH: ec00290  Valine, leucine and isoleucine biosynthesis
PATH: ec01100  Metabolic pathways
Orthology KO: K00263  leucine dehydrogenase
Genes XCC: XCC1299(leu)
XCB: XC_2941
XCA: xccb100_3003
XCV: XCV1403(ldh)
XAC: XAC1350(leu)
XOO: XOO1883(leu)
XOM: XOO_1780
XOP: PXO_01746
SML: Smlt3523(vdh)
SMT: Smal_2953
PAE: PA3418(ldh)
PAU: PA14_19870(ldh)
PAP: PSPA7_1708(ldh)
PAG: PLES_16421(ldh)
PPU: PP_4617
PPF: Pput_4477
PPG: PputGB1_4601
PPW: PputW619_0821
PFL: PFL_0973(ldh)
PFO: Pfl01_0915
PFS: PFLU1030
PEN: PSEEN4606
PMY: Pmen_2875 Pmen_3248
PSA: PST_0867(ldh)
AVN: Avin_10760
SON: SO_2638(ldh)
SDN: Sden_1823
SFR: Sfri_2265
SAZ: Sama_2067
SBL: Sbal_2483
SBM: Shew185_2476
SBN: Sbal195_2596
SBP: Sbal223_1868
SPC: Sputcn32_2238
SSE: Ssed_1877
SPL: Spea_2543
SHE: Shewmr4_1598
SHM: Shewmr7_1673
SHN: Shewana3_1742
SHW: Sputw3181_1771
SHL: Shal_1711
SWD: Swoo_2710
SWP: swp_1857
ILO: IL1314
CPS: CPS_2904
PHA: PSHAa1167(bcd)
PAT: Patl_2995
MAQ: Maqu_2878
AMC: MADE_02824
CBU: CBU_0641
CBS: COXBURSA331_A0755
CBD: CBUD_0652
CBG: CbuG_1363
CBC: CbuK_1615
LPN: lpg2276
LPF: lpl2202
LPP: lpp2230
LPC: LPC_1745
NOC: Noc_1436
HCH: HCH_00319
KKO: Kkor_1133
REU: Reut_B5816 Reut_C6219
REH: H16_B0449
BXE: Bxe_A2689
BPH: Bphy_3953
TMZ: Tmz1t_1037
BBA: Bd2028
MXA: MXAN_1074
SCL: sce6206
HOH: Hoch_4303
MES: Meso_3241
CCR: CC_2082
CCS: CCNA_02164
CAK: Caul_3328
PZU: PHZ_c0894
SIL: SPO0390
SIT: TM1040_2779
PDE: Pden_4625
MMR: Mmar10_0963
HNE: HNE_1615(ldh1) HNE_2735(ldh2)
HBA: Hbal_2132
SAL: Sala_1521 Sala_1973
SWI: Swit_3986
ELI: ELI_03850
RRU: Rru_A1040
RCE: RC1_1776
BSU: BSU24080(bcd)
BHA: BH2765
BAN: BA4387
BAR: GBAA4387
BAA: BA_4842
BAT: BAS4070
BAH: BAMEG_4424
BAI: BAA_4406
BCE: BC4162
BCA: BCE_4237
BCZ: BCZK3917(dhlE)
BCR: BCAH187_A4295
BCB: BCB4264_A4275
BCU: BCAH820_4185
BCG: BCG9842_B0959
BCQ: BCQ_3952(dhlE)
BCX: BCA_4274
BCY: Bcer98_2859
BTK: BT9727_3908(dhlE)
BTL: BALH_3775(dhlE)
BWE: BcerKBAB4_4006
BLI: BL01501(bcd)
BLD: BLi02585(bcd)
BCL: ABC2453(bcd)
BAY: RBAM_022360(bcd)
BPU: BPUM_2147(bcd)
OIH: OB1869
GKA: GK2381
GTN: GTNG_2310
GWC: GWCH70_2308
GYC: GYMC61_0262
AFL: Aflv_0959(bcd)
LSP: Bsph_3496
ESI: Exig_0916
EAT: EAT1b_0510
MCL: MCCL_1161
BBE: BBR47_23670(ldh)
PJD: Pjdr2_5970
AAC: Aaci_1459
STH: STH1827 STH1830
TTE: TTE2202(gdhA3) TTE2203(gdhA4)
TEX: Teth514_0938
TPD: Teth39_0461
CHY: CHY_0579(ldh)
NTH: Nther_1681 Nther_2349
HOR: Hore_06730 Hore_06750
RHA: RHA1_ro01628
RER: RER_40180(vdh)
ROP: ROP_13250(vdh)
GBR: Gbro_4113
BCV: Bcav_4087
KSE: Ksed_04400
TCU: Tcur_0296
SRO: Sros_8995
SVI: Svir_28230
CAI: Caci_0299 Caci_4348
RXY: Rxyl_2467
CTR: CT773(ldh)
CTA: CTA_0843(ldh)
CTB: CTL0142(ldh)
CTL: CTLon_0142(ldh)
CTJ: JALI_7781(ldh)
CMU: TC0154
CPN: CPn0919(ldh)
CPA: CP0947
CPJ: CPj0919(ldh)
CPT: CpB0951
CCA: CCA00850
CAB: CAB815
CFE: CF0166(gdhA)
PHE: Phep_1400
GFO: GFO_2528(ldh)
FJO: Fjoh_2201
FPS: FP0533(vdh)
AAS: Aasi_0423
GAU: GAU_1293
SYD: Syncc9605_0225
SYE: Syncc9902_0253
SYG: sync_0270
SYR: SynRCC307_2295
SYX: SynWH7803_0275
CYC: PCC7424_2278
ANA: all0426
NPU: Npun_R1275
PMC: P9515_04091
PMH: P9215_04071
DRA: DR_0158
DGE: Dgeo_0203
DDR: Deide_00380
Taxonomy
Structures PDB: 1LEH  
Reference
  Authors
  Title
  Journal
  Organism
 1  [PMID:13746411]
SANWAL BD, ZINK MW.
L-Leucine dehydrogenase of Bacillus cereus.
Arch. Biochem. Biophys. 94 (1961) 430-5.
Bacillus cereus
Reference
  Authors
  Title

  Journal
 2
Zink, M.W. and Sanwal, B.D.
The distribution and substrate specificity of L-leucine
dehydrogenase.
Arch. Biochem. Biophys. 99 (1962) 72-77.
Other DBs ExplorEnz - The Enzyme Database: 1.4.1.9
IUBMB Enzyme Nomenclature: 1.4.1.9
ExPASy - ENZYME nomenclature database: 1.4.1.9
BRENDA, the Enzyme Database: 1.4.1.9
CAS: 9082-71-7
DBGET integrated database retrieval system