| Entry |
|
|---|
| Name |
L-amino-acid oxidase;
ophio-amino-acid oxidase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
 |
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| Sysname |
L-amino-acid:oxygen oxidoreductase (deaminating) |
|---|
| Reaction(IUBMB) |
an L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2 [RN:R01259] |
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| Reaction(KEGG) |
R01259 > R00357 R00648 R00677 R00689 R00729 R02197;
(other) R06124
 |
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| Substrate |
L-amino acid [CPD:C00151];
H2O [CPD:C00001];
O2 [CPD:C00007] |
|---|
| Product |
2-oxo acid [CPD:C00161];
NH3 [CPD:C00014];
H2O2 [CPD:C00027] |
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| Cofactor |
FAD [CPD:C00016] |
|---|
| Comment |
A flavoprotein (FAD). |
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| Pathway |
PATH: ec00250 Alanine, aspartate and glutamate metabolism
PATH: ec00270 Cysteine and methionine metabolism
PATH: ec00280 Valine, leucine and isoleucine degradation
PATH: ec00350 Tyrosine metabolism
PATH: ec00360 Phenylalanine metabolism
PATH: ec00380 Tryptophan metabolism
PATH: ec00400 Phenylalanine, tyrosine and tryptophan biosynthesis
PATH: ec00950 Isoquinoline alkaloid biosynthesis
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K03334 L-amino-acid oxidase |
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| Genes |
HSA: 259307(IL4I1)
MCC: 719114(IL4I1)
MMU: 14204(Il4i1)
RNO: 298483(Lao1)
CFA: 482436 484371(IL4I1)
BTA: 782545
ECB: 100147151 100147304
MDO: 100032718
GGA: 417039(LAO)
TGU: 100222394
DRE: 556554
 |
|---|
| Structures |
PDB: 1F8R 1F8S 1REO 1TDK 1TDN 1TDO 2IID 2JAE 2JB1 2JB2
2JB3 |
|---|
Reference
Authors
Title
Journal
|
1
Meister, A. and Wellner, D.
Flavoprotein amino acid oxidase.
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd
ed., vol. 7, Academic Press, New York, 1963, p. 609-648. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:13843884]
WELLNER D, MEISTER A.
Crystalline L-amino acid oxidase of Crotalus adamanteus.
J. Biol. Chem. 235 (1960) 2013-8.
Crotalus adamanteus |
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| Other DBs |
ExplorEnz - The Enzyme Database: 1.4.3.2
IUBMB Enzyme Nomenclature: 1.4.3.2
ExPASy - ENZYME nomenclature database: 1.4.3.2
BRENDA, the Enzyme Database: 1.4.3.2
CAS: 9000-89-9 |
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