KEGG   ENZYME: 1.4.99.1Help
Entry
EC 1.4.99.1                 Enzyme                                 
Name D-amino-acid dehydrogenase;
D-amino-acid:(acceptor) oxidoreductase (deaminating)
Class Oxidoreductases;
Acting on the CH-NH2 group of donors;
With other acceptors
BRITE hierarchy
Sysname D-amino-acid:acceptor oxidoreductase (deaminating)
Reaction(IUBMB) a D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced
acceptor [RN:R07166]
Reaction(KEGG) R07166 > R01374;
(other) R01342
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Substrate D-amino acid [CPD:C00405];
H2O [CPD:C00001];
acceptor [CPD:C00028]
Product 2-oxo acid [CPD:C00161];
NH3 [CPD:C00014];
reduced acceptor [CPD:C00030]
Cofactor FAD [CPD:C00016]
Comment A flavoprotein (FAD). Acts to some extent on all D-amino acids,
except D-aspartate and D-glutamate.
Pathway PATH: ec00360  Phenylalanine metabolism
PATH: ec00910  Nitrogen metabolism
Orthology KO: K00285  D-amino-acid dehydrogenase
Genes ECO: b1189(dadA)
ECJ: JW1178(dadA)
ECD: ECDH10B_1242(dadA)
EBW: BWG_1014(dadA)
ECE: Z1952(dadA)
ECS: ECs1684
ECF: ECH74115_1676(dadA)
ETW: ECSP_1586(dadA)
ECG: E2348C_1308(dadA)
ECC: c1638(dadA)
ECI: UTI89_C1375(dadA)
ECP: ECP_1232
ECV: APECO1_301(dadA)
ECW: EcE24377A_1334(dadA)
ECX: EcHS_A1292(dadA)
ECM: EcSMS35_1960(dadA)
ECY: ECSE_1237
ECL: EcolC_2436
ECK: EC55989_1284(dadA)
ECQ: ECED1_1331(dadA)
ECR: ECIAI1_1206(dadA)
ECT: ECIAI39_1881(dadA)
ECZ: ECS88_1252(dadA)
EUM: ECUMN_1478(dadA)
ELF: LF82_0433(dadA)
EBL: B21_01174(dadA)
EBD: ECBD_2433
EBR: ECB_01164(dadA)
EOH: ECO103_1291(dadA)
EOI: ECO111_1518(dadA)
EOJ: ECO26_1702(dadA)
EFE: EFER_1149(dadA) EFER_1766(dadA)
STY: STY1931(dadA)
STT: t1074(dadA)
SPT: SPA1070(dadA)
SEK: SSPA0999
SPQ: SPAB_01416
SEI: SPC_1926(dadA)
SEC: SC1796(dadA)
SEH: SeHA_C2001
SEE: SNSL254_A1941
SEW: SeSA_A1945
SEA: SeAg_B1330
SED: SeD_A1515
SET: SEN1234(dadA)
SES: SARI_01136
STM: STM1803(dadA)
YPE: YPO2147(dadA)
YPK: y2174(dadA)
YPM: YP_1948(dadA1)
YPA: YPA_1505
YPN: YPN_1614
YPG: YpAngola_A2361(dadA)
YPP: YPDSF_0986
YPS: YPTB2074(dadA)
YPI: YpsIP31758_1997(dadA)
YPY: YPK_2107
YPB: YPTS_2136
YEN: YE2281(dadA)
SFL: SF1178(dadA)
SFX: S1266(dadA)
SFV: SFV_1196(dadA)
SSN: SSON_1181(dadA)
SBO: SBO_1883(dadA)
SBC: SbBS512_E1347(dadA)
SDY: SDY_1226(dadA)
ECA: ECA2351(dadA)
PCT: PC1_1957
PWA: Pecwa_2253
ETA: ETA_15440(dadA)
PLU: plu2561(dadA)
PAY: PAU_01970(dadA)
ENT: Ent638_2363
ESA: ESA_01469
CTU: Ctu_24610(dadA)
KPN: KPN_02172 KPN_02309(dadA)
KPE: KPK_1985(dadA) KPK_2146
KPU: KP1_3276 KP1_3432(dadA)
CKO: CKO_01193
SPE: Spro_2746
PMR: PMI1509(dadA)
EIC: NT01EI_1632
ETR: ETAE_1474(dadA)
DDA: Dd703_1813 Dd703_1981
DDC: Dd586_1863 Dd586_1996
DZE: Dd1591_2005
XFA: XF0851
XFT: PD1824
XFM: Xfasm12_2000
XFN: XfasM23_1924
XCC: XCC2580(dadA) XCC3648(dadA)
XCB: XC_1538 XC_3719
XCA: xccb100_1581(dadA1) xccb100_3834(dadA2)
XCV: XCV2904(dadA) XCV3809(dadA2)
XAC: XAC2751(dadA) XAC3688(dadA)
XOO: XOO0693(dadA) XOO3288(dadA)
XOM: XOO_0630 XOO_3111
XOP: PXO_01910 PXO_03073
SML: Smlt0567 Smlt3457
SMT: Smal_0444
VCH: VC0786
VCO: VC0395_A0313(dadA)
VCM: VCM66_0744(dadA)
VCJ: VCD_003540
VVU: VV1_0414
VVY: VV0781
VPA: VP0623 VP1331
VSP: VS_1133
VEX: VEA_003672 VEA_004326
PPR: PBPRB1593
PAE: PA5084 PA5304(dadA)
PAU: PA14_67150 PA14_70040(dadA)
PAP: PSPA7_5823 PSPA7_6078(dadA)
PAG: PLES_54741 PLES_56991(dadA)
PPU: PP_1255 PP_3596 PP_4311 PP_4434(dadA-1) PP_5270(dadA-2)
PPF: Pput_1282 Pput_1556 Pput_2176 Pput_5180
PPG: PputGB1_2320 PputGB1_3877 PputGB1_4136 PputGB1_5322
PPW: PputW619_0200 PputW619_2811 PputW619_3638
PST: PSPTO_0101(dadA)
PSB: Psyr_0235
PSP: PSPPH_0223(dadA)
PFL: PFL_2195 PFL_3591 PFL_5808(dadA) PFL_6038(dadA)
PFO: Pfl01_2305 Pfl01_5290 Pfl01_5526
PFS: PFLU3327 PFLU5731 PFLU5968(dadA)
PEN: PSEEN1658 PSEEN2664 PSEEN4053 PSEEN5416(dadA)
PMY: Pmen_0245
PSA: PST_0483(dadA) PST_2205 PST_4110
AVN: Avin_47980(dadA)
PAR: Psyc_0158(dadA) Psyc_1346
PCR: Pcryo_0168 Pcryo_0900 Pcryo_1018 Pcryo_1218
PRW: PsycPRwf_0474
ACI: ACIAD0115(dadA) ACIAD1998(dadA)
ACB: A1S_0095 A1S_1075 A1S_1984
ABM: ABSDF0116(dadA) ABSDF1670(dadA)
ABY: ABAYE1567(dadA) ABAYE3774(dadA)
ABC: ACICU_00123 ACICU_02107
ABN: AB57_0138 AB57_2330
ABB: ABBFA_001462 ABBFA_003422
SAZ: Sama_1533
SLO: Shew_2360
SSE: Ssed_1764 Ssed_3545
SPL: Spea_0813 Spea_1706
SHL: Shal_0867 Shal_2553
SWD: Swoo_2820
SWP: swp_1986
CPS: CPS_1447 CPS_2746
MAQ: Maqu_2864
PIN: Ping_2082
AEH: Mlg_0415
HHA: Hhal_1817
HNA: Hneap_2389
HCH: HCH_00170 HCH_03166
CSA: Csal_1318 Csal_1724 Csal_2708
MMW: Mmwyl1_0203 Mmwyl1_3630 Mmwyl1_3891
AHA: AHA_1961
ASA: ASA_2333(dadA)
AFE: Lferr_0868
AFR: AFE_0720
NMA: NMA0092(dadA)
NME: NMB0176(dadA)
NMC: NMC0166(dadA)
NMN: NMCC_1976(dadA)
NMI: NMO_1862(dadA)
NGO: NGO1808
NGK: NGK_2465
CVI: CV_1914(dadA2) CV_2823(dadA1) CV_3692
LHK: LHK_00934
RSO: RSc0507 RSc0926(dadA) RSc2262
RPI: Rpic_0383 Rpic_0796 Rpic_2467 Rpic_4307 Rpic_4901
RPF: Rpic12D_0398 Rpic12D_0867 Rpic12D_2074 Rpic12D_3824
     Rpic12D_4417
REU: Reut_A1655 Reut_A2547 Reut_A2589 Reut_B3726
REH: H16_A0770(dadA2) H16_A0817(dadA1) H16_A1505(dadA5)
     H16_B0508(dadA6)
RME: Rmet_0700 Rmet_0740 Rmet_1877 Rmet_4441 Rmet_5580
CTI: RALTA_A0757(dadA3) RALTA_A0798(dadA1) RALTA_A1443(dadA2)
     RALTA_B0324 RALTA_B1215
BMA: BMA0408(dadA) BMA1447 BMAA1933
BMV: BMASAVP1_0948 BMASAVP1_A1939 BMASAVP1_A2551(dadA)
BML: BMA10229_1236 BMA10229_A0927(dadA) BMA10229_A3366
BMN: BMA10247_0222 BMA10247_1212 BMA10247_A2211
BPS: BPSL1415 BPSL2497(dadA) BPSS0154(dadA) BPSS0574
BPM: BURPS1710b_2464(dadA) BURPS1710b_2974(dadA)
     BURPS1710b_A1670(dadA) BURPS1710b_A2137(dadA)
BPL: BURPS1106A_2344 BURPS1106A_2925 BURPS1106A_A0215
     BURPS1106A_A0770
BPD: BURPS668_2305 BURPS668_2864 BURPS668_A0305 BURPS668_A0860
BPR: GBP346_A2414 GBP346_A3044
BTE: BTH_I1656 BTH_I2134 BTH_II0223 BTH_II1840
BVI: Bcep1808_0985 Bcep1808_1847 Bcep1808_3377 Bcep1808_6420
     Bcep1808_6673 Bcep1808_6677
BUR: Bcep18194_A3504 Bcep18194_A3940 Bcep18194_A4178 Bcep18194_A5216
     Bcep18194_B0064 Bcep18194_B0629
BCN: Bcen_0367 Bcen_0585 Bcen_1434 Bcen_2701 Bcen_3334 Bcen_6164
     Bcen_6408
BCH: Bcen2424_0406 Bcen2424_0850 Bcen2424_1064 Bcen2424_1915
     Bcen2424_5033 Bcen2424_6394 Bcen2424_6641
BCM: Bcenmc03_0385 Bcenmc03_0822 Bcenmc03_1023 Bcenmc03_1938
     Bcenmc03_5251 Bcenmc03_6239
BCJ: BCAL0293 BCAL1988 BCAL2933(dadA) BCAL3155 BCAM2276
BAM: Bamb_0725 Bamb_0940 Bamb_1903 Bamb_3394 Bamb_4442
BAC: BamMC406_0742 BamMC406_0944 BamMC406_1833 BamMC406_3227
     BamMC406_4962 BamMC406_6455
BMU: Bmul_0309 Bmul_1359 Bmul_2240 Bmul_2537 Bmul_3604 Bmul_5266
BMJ: BMULJ_00701(dadA) BMULJ_00999(dadA) BMULJ_01884(dadA)
     BMULJ_02945(dadA) BMULJ_03254(dadA) BMULJ_04913(dadA)
BXE: Bxe_A0369 Bxe_A1001 Bxe_A2285 Bxe_B0799 Bxe_B1348 Bxe_B1416
     Bxe_C0404
BPH: Bphy_0765 Bphy_1021 Bphy_3433 Bphy_4708 Bphy_5465 Bphy_6619
BPY: Bphyt_1916 Bphyt_2070 Bphyt_2982 Bphyt_3589 Bphyt_3716
     Bphyt_4229 Bphyt_4480 Bphyt_5338
BGL: bglu_1g08980 bglu_1g13610 bglu_2g06180
BPE: BP1818(dadA) BP2210 BP3009
BPA: BPP1901(dadA) BPP2721(dadA3) BPP3086(dadA) BPP3738 BPP3800
BBR: BB2777(dadA3) BB3049(dadA) BB3089 BB3209(dadA) BB4184 BB4245
BPT: Bpet0709 Bpet1260(dadA) Bpet1992 Bpet2578 Bpet2614
BAV: BAV0960(dadA1) BAV2005(dadA2) BAV2030(dadA3) BAV2366(dadA4)
RFR: Rfer_0240 Rfer_1987
POL: Bpro_0148 Bpro_1385 Bpro_1999 Bpro_2697 Bpro_4194
PNA: Pnap_0094 Pnap_1756
AAV: Aave_0131 Aave_1822 Aave_1936 Aave_2554 Aave_4507
AJS: Ajs_0071 Ajs_2587 Ajs_3886
VEI: Veis_0793 Veis_2001 Veis_4473 Veis_4738 Veis_5009
DAC: Daci_0069 Daci_0528 Daci_3117 Daci_4949
DIA: Dtpsy_0090 Dtpsy_1221 Dtpsy_3159
VAP: Vapar_0751 Vapar_1545 Vapar_2597 Vapar_3174 Vapar_3676
     Vapar_3967 Vapar_5589
CTT: CtCNB1_0060 CtCNB1_0077 CtCNB1_0952
MPT: Mpe_A1981 Mpe_A3520
HAR: HEAR0360 HEAR0740(dadA) HEAR1744
MMS: mma_0406(dadA1) mma_0667(dadA2) mma_1540(dadA3)
LCH: Lcho_0948 Lcho_2380 Lcho_2852
EBA: ebA1192(dadA)
AZO: azo0967(dadA1) azo3924(dadA2)
DAR: Daro_3842
TMZ: Tmz1t_1408
MFA: Mfla_0791
MEI: Msip34_1863
APP: CAP2UW1_0929
HPY: HP0943
HPJ: jhp0878(dadA)
HPA: HPAG1_0926
HPS: HPSH_04965
HPG: HPG27_892
HPP: HPP12_0940(dadA)
HPB: HELPY_0929
HAC: Hac_1311(dadA)
CCV: CCV52592_0817
CCO: CCC13826_1160
BBA: Bd0322(dadA)
PUB: SAR11_1368(dadA)
MLO: mll3980 mll3992 mll6285 mlr5698 mlr9201
MES: Meso_0395 Meso_1828 Meso_1843 Meso_1866 Meso_3322 Meso_4364
PLA: Plav_0886
SME: SM_b20267 SMc00797 SMc03265
SMD: Smed_0342 Smed_2093 Smed_3864
ATU: Atu3293(dadA) Atu3364 Atu4682(dadA)
ATC: AGR_C_323 AGR_L_2918 AGR_L_3050 AGR_L_400
ARA: Arad_0729 Arad_0990 Arad_7296(dadA) Arad_7416 Arad_8335(dadA)
AVI: Avi_0844(dadA) Avi_6079(dadA)
RET: RHE_CH00451(ypch00165) RHE_CH00742(ypch00248) RHE_PF00436(dadA)
REC: RHECIAT_CH0000518 RHECIAT_CH0000821 RHECIAT_PC0000646
     RHECIAT_PC0000659(dadA)
RLE: RL0477(dadA) RL0784 RL2917(dadA) pRL120417(dadA)
RLT: Rleg2_0106 Rleg2_0122 Rleg2_0396 Rleg2_4831 Rleg2_4843
     Rleg2_6265
RLG: Rleg_0116 Rleg_0428 Rleg_2449 Rleg_4777
RHI: NGR_b07060(dadA) NGR_c03590 NGR_c30170
BME: BMEI0256 BMEII0373
BMI: BMEA_B0604 BMEA_B0906
BMF: BAB1_1801 BAB2_0311 BAB2_0613
BMB: BruAb1_1774 BruAb2_0309(dadA) BruAb2_0596
BMC: BAbS19_I16830 BAbS19_II02950 BAbS19_II05730
BMS: BRA0630 BRA0924(dadA)
BMT: BSUIS_B0626 BSUIS_B0916 BSUIS_B1269
BOV: BOV_1727 BOV_A0592 BOV_A0866(dadA)
BCS: BCAN_A1831 BCAN_B0630 BCAN_B0943(dadA)
BMR: BMI_I1810 BMI_II627 BMI_II918(dadA)
OAN: Oant_1110 Oant_1444 Oant_3709 Oant_4074
BJA: bll4301 bll6812 blr2222(dadA)
BRA: BRADO3486 BRADO4568
BBT: BBta_1259 BBta_4795
RPA: RPA3774
RPB: RPB_1124 RPB_1503 RPB_3648
RPC: RPC_1652
RPD: RPD_1816
RPE: RPE_1682
RPT: Rpal_4295
NWI: Nwi_2282
NHA: Nham_2698
XAU: Xaut_2304
AZC: AZC_0820 AZC_2023 AZC_2066 AZC_2952
MRD: Mrad2831_1542 Mrad2831_4821 Mrad2831_5562
MET: M446_2122 M446_3464 M446_3636
MNO: Mnod_1094 Mnod_3651 Mnod_3970 Mnod_4261 Mnod_6396
PZU: PHZ_c0060
SIL: SPO0543 SPO3666 SPOA0168 SPOA0262
SIT: TM1040_0355 TM1040_2064 TM1040_3200
RSP: RSP_2316(dadA) RSP_3113(dadA)
RSH: Rsph17029_0990 Rsph17029_3842
RSQ: Rsph17025_1613
RSK: RSKD131_0638 RSKD131_3292
JAN: Jann_1410 Jann_2880
RDE: RD1_0238
PDE: Pden_0183 Pden_0804 Pden_4628 Pden_4860
DSH: Dshi_0558(dadA)
MMR: Mmar10_2102
HNE: HNE_2416(dadA)
SWI: Swit_0808
GOX: GOX0632
GBE: GbCGDNIH1_0502
GDI: GDI_0709(dadA) GDI_2422(dadA)
GDJ: Gdia_0673 Gdia_1301
APT: APA01_06230 APA01_24980
RRU: Rru_A1546 Rru_A2064
MAG: amb2799
BAN: BA2715
BAR: GBAA2715
BAA: BA_3236
BAT: BAS2529
BAH: BAMEG_1880
BAI: BAA_2779
BCE: BC2723
BCA: BCE_2742
BCZ: BCZK2454(dadA) pE33L466_0322(dadA)
BCR: BCAH187_A2777
BCB: BCB4264_A2732
BCU: BCAH820_2728
BCG: BCG9842_B2569
BCQ: BCQ_2570(dadA)
BCX: BCA_2803
BCY: Bcer98_1848
BTK: BT9727_2489(dadA)
BTL: BALH_2442
BWE: BcerKBAB4_2430
BCL: ABC2595
BAY: RBAM_029710(yurR)
GKA: GK1399
GTN: GTNG_1252
GWC: GWCH70_1426
GYM: GYMC10_2759
GYC: GYMC61_2192
AFL: Aflv_1550
LWE: lwe1929
ESI: Exig_1676
EAT: EAT1b_0144
PJD: Pjdr2_2975
MSM: MSMEG_6291
MVA: Mvan_4780
MGI: Mflv_0955
MMC: Mmcs_5235
MKM: Mkms_5323
MJL: Mjls_5615
CGL: NCgl2909(cgl3012)
CGB: cg3340(dadA)
CGT: cgR_2900
CEF: CE2845
RHA: RHA1_ro01324 RHA1_ro02152(dadA2)
RER: RER_15220
ROP: ROP_18690
BCV: Bcav_1087
NCA: Noca_0647
TFU: Tfu_2797
SRO: Sros_2431 Sros_5199
FRA: Francci3_3470
FRE: Franean1_1275
FAL: FRAAL5656
SEN: SACE_4702(dadA2) SACE_5427(dadA2)
SVI: Svir_10140 Svir_23290
AMI: Amir_3596
RXY: Rxyl_1818 Rxyl_2256
AFO: Afer_0198
RMR: Rmar_0499
DFE: Dfer_4274
CPI: Cpin_5571
RBI: RB2501_11857
RBA: RB5278(dadA)
STI: Sthe_0189
TTR: Tter_1324
Taxonomy
Structures PDB: 1FE2  1IGX  1IGZ  
Reference
  Authors
  Title
  Journal
  Organism
 1  [PMID:5925166]
Tsukada K.
D-amino acid dehydrogenases of Pseudomonas fluorescens.
J. Biol. Chem. 241 (1966) 4522-8.
Pseudomonas fluorescens
Other DBs ExplorEnz - The Enzyme Database: 1.4.99.1
IUBMB Enzyme Nomenclature: 1.4.99.1
ExPASy - ENZYME nomenclature database: 1.4.99.1
BRENDA, the Enzyme Database: 1.4.99.1
CAS: 37205-44-0
DBGET integrated database retrieval system