| Entry |
|
|---|
| Name |
aralkylamine dehydrogenase;
aromatic amine dehydrogenase;
dehydrogenase, arylamine;
tyramine dehydrogenase;
aromatic amine dehydrogenase;
aralkylamine:(acceptor) oxidoreductase (deaminating) |
|---|
| Class |
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With other acceptors
 |
|---|
| Sysname |
aralkylamine:acceptor oxidoreductase (deaminating) |
|---|
| Reaction(IUBMB) |
RCH2NH2 + H2O + acceptor = RCHO + NH3 + reduced acceptor [RN:R01854] |
|---|
| Reaction(KEGG) |
R01854 > R02612;
(other) R02382 R04300
 |
|---|
| Substrate |
RCH2NH2 [CPD:C00375];
H2O [CPD:C00001];
acceptor [CPD:C00028] |
|---|
| Product |
RCHO [CPD:C00071];
NH3 [CPD:C00014];
reduced acceptor [CPD:C00030] |
|---|
| Comment |
Phenazine methosulfate can act as acceptor. Acts on aromatic amines
and, more slowly, on some long-chain aliphatic amines, but not on
methylamine or ethylamine (cf. EC 1.4.99.3 amine dehydrogenase). |
|---|
| Pathway |
PATH: ec00350 Tyrosine metabolism
PATH: ec00360 Phenylalanine metabolism
PATH: ec00950 Isoquinoline alkaloid biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K13371 aralkylamine dehydrogenase light chain
KO: K13372 aralkylamine dehydrogenase heavy chain |
|---|
| Structures |
PDB: 2AGL 2AGW 2AGX 2AGY 2AGZ 2AH0 2AH1 2H3X 2H47 2HJ4
2HJB 2HKM 2HKR 2HXC 2I0R 2I0S 2I0T 2IAA 2IUP 2IUQ
2IUR 2IUV 2OIZ 2OJY 2OK4 2OK6 2Q7Q |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:6830237]
Iwaki M, Yagi T, Horiike K, Saeki Y, Ushijima T, Nozaki M.
Crystallization and properties of aromatic amine dehydrogenase from
Pseudomonas sp.
Arch. Biochem. Biophys. 220 (1983) 253-62.
Pseudomonas sp. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.4.99.4
IUBMB Enzyme Nomenclature: 1.4.99.4
ExPASy - ENZYME nomenclature database: 1.4.99.4
BRENDA, the Enzyme Database: 1.4.99.4
CAS: 85030-73-5 |
|---|
