| Entry |
|
|---|
| Name |
pyrroline-2-carboxylate reductase;
Delta1-pyrroline-2-carboxylate reductase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
L-proline:NAD(P)+ 2-oxidoreductase |
|---|
| Reaction(IUBMB) |
L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+
[RN:R01246 R01249] |
|---|
| Reaction(KEGG) |
R01246 R01249;
(other) R02201 R02203
 |
|---|
| Substrate |
L-proline [CPD:C00148];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006] |
|---|
| Product |
1-pyrroline-2-carboxylate [CPD:C03564];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Comment |
Reduces 1-pyrroline-2-carboxylate to L-proline and also
1,2-didehydropiperidine-2-carboxylate to L-pipecolate. |
|---|
| Pathway |
PATH: ec00310 Lysine degradation
PATH: ec00330 Arginine and proline metabolism
PATH: ec01100 Metabolic pathways |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13502341]
MEISTER A, RADHAKRISHNAN AN, BUCKLEY SD.
Enzymatic synthesis of L-pipecolic acid and L-proline.
J. Biol. Chem. 229 (1957) 789-800.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.5.1.1
IUBMB Enzyme Nomenclature: 1.5.1.1
ExPASy - ENZYME nomenclature database: 1.5.1.1
BRENDA, the Enzyme Database: 1.5.1.1
CAS: 9029-16-7 |
|---|
