| Entry |
|
|---|
| Name |
saccharopine dehydrogenase (NADP+, L-glutamate-forming);
saccharopine (nicotinamide adenine dinucleotide phosphate,
glutamate-forming) dehydrogenase;
aminoadipic semialdehyde-glutamic reductase;
aminoadipate semialdehyde-glutamate reductase;
aminoadipic semialdehyde-glutamate reductase;
epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase
(L-2-aminoadipate-semialdehyde forming);
saccharopine reductase;
6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase
(L-glutamate-forming) |
|---|
| Class |
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase
(L-glutamate-forming) |
|---|
| Reaction(IUBMB) |
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-glutamate +
L-2-aminoadipate 6-semialdehyde + NADPH + H+ [RN:R02315] |
|---|
| Reaction(KEGG) |
R02315
 |
|---|
| Substrate |
N6-(L-1,3-dicarboxypropyl)-L-lysine [CPD:C00449];
NADP+ [CPD:C00006];
H2O [CPD:C00001] |
|---|
| Product |
L-glutamate [CPD:C00025];
L-2-aminoadipate 6-semialdehyde [CPD:C04076];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Pathway |
PATH: ec00300 Lysine biosynthesis
PATH: ec00310 Lysine degradation
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00293 saccharopine dehydrogenase (NADP+, L-glutamate forming) |
|---|
| Genes |
SCE: YNR050C(LYS9)
AGO: AGOS_ABR116C
KLA: KLLA0C18744g
DHA: DEHA0F18865g
PIC: PICST_70210(LYS9)
CAL: CaO19.7448(LYS9)
CGR: CAGL0C03443g
YLI: YALI0D22891g
SPO: SPBC3B8.03
NCR: NCU03748
MGR: MGG_08564
ANI: AN5601.2
AFM: AFUA_4G11340
AOR: AO090003001086
ANG: An04g05260
DDI: DDB_0238270(sdh)
SIT: TM1040_0106
HMA: rrnAC0132
 |
|---|
| Structures |
PDB: 1E5L 1E5Q 2AXQ |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4380448]
Jones EE, Broquist HP.
Saccharopine, an intermediate of the aminoadipic acid pathway of
lysine biosynthesis. 3. Aminoadipic semialdehyde-glutamate
reductase.
J. Biol. Chem. 241 (1966) 3430-4.
Saccharomyces cerevisiae [GN:sce] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.5.1.10
IUBMB Enzyme Nomenclature: 1.5.1.10
ExPASy - ENZYME nomenclature database: 1.5.1.10
BRENDA, the Enzyme Database: 1.5.1.10
CAS: 9033-55-0 |
|---|
