KEGG   ENZYME: 1.5.1.15Help
Entry
EC 1.5.1.15                 Enzyme                                 
Name methylenetetrahydrofolate dehydrogenase (NAD+);
methylenetetrahydrofolate dehydrogenase (NAD+)
Class Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase
Reaction(IUBMB) 5,10-methylenetetrahydrofolate + NAD+ =
5,10-methenyltetrahydrofolate + NADH + H+ [RN:R01218]
Reaction(KEGG) R01218
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Substrate 5,10-methylenetetrahydrofolate [CPD:C00143];
NAD+ [CPD:C00003]
Product 5,10-methenyltetrahydrofolate [CPD:C00445];
NADH [CPD:C00004];
H+ [CPD:C00080]
Pathway PATH: ec00670  One carbon pool by folate
PATH: ec01100  Metabolic pathways
Orthology KO: K00295  methylenetetrahydrofolate dehydrogenase (NAD+)
Genes HSA: 10797(MTHFD2)
PTR: 461253(MTHFD2L)
MCC: 702907
MMU: 17768(Mthfd2)
RNO: 313410(RGD1564040) 680308(Mthfd2)
CFA: 483107(MTHFD2)
BTA: 517539(MTHFD2)
ECB: 100053990
MDO: 100023851 100024210
GGA: 426126(RCJMB04_12b8)
TGU: 100224318
XLA: 446641(mthfd2)
XTR: 100170462
DRE: 100004977(mthfd2)
BFO: BRAFLDRAFT_62006
CIN: 100186867
SPU: 588966
DME: Dmel_CG18466(Nmdmc)
DAN: Dana_GF18431
DSE: Dsec_GM26287
DSI: Dsim_GD20823
DGR: Dgri_GH18238
DMO: Dmoj_GI10194
AGA: AgaP_AGAP004677
AAG: AaeL_AAEL014871
CQU: CpipJ_CPIJ004710
NVI: 100116505
API: 100164363
TAD: TRIADDRAFT_50697
SCE: YKR080W(MTD1)
AGO: AGOS_ADR214W
KLA: KLLA0A07953g
DHA: DEHA0E04081g
PIC: PICST_73792
YLI: YALI0B12078g
SPO: SPBC1711.04
NCR: NCU00963
MGR: MGG_10834
ANI: AN1524.2
AFM: AFUA_8G05330
AOR: AO090005000616
ANG: An16g07400
CNE: CNF03710
DDI: DDB_0230118(thfA)
MMO: MMOB1600(folD)
Taxonomy
Structures PDB: 1EDZ  1EE9  
Reference
  Authors
  Title


  Journal
  Organism
 1  [PMID:4153026]
Moore MR, O'Brien WE, Ljungdahl LG.
Purification and characterization of nicotinamide adenine
dinucleotide-dependent methylenetetrahydrofolate dehydrogenase from
Clostridium formicoaceticum.
J. Biol. Chem. 249 (1974) 5250-3.
Clostridium formicoaceticum
Other DBs ExplorEnz - The Enzyme Database: 1.5.1.15
IUBMB Enzyme Nomenclature: 1.5.1.15
ExPASy - ENZYME nomenclature database: 1.5.1.15
BRENDA, the Enzyme Database: 1.5.1.15
CAS: 82062-90-6
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