KEGG   ENZYME: 1.5.1.25Help
Entry
EC 1.5.1.25                 Enzyme                                 

Name
thiomorpholine-carboxylate dehydrogenase;
ketimine reductase;
ketimine-reducing enzyme
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase
Reaction(IUBMB)
thiomorpholine 3-carboxylate + NAD(P)+ = 3,4-dehydro-thiomorpholine-3-carboxylate + NAD(P)H + H+ [RN:R04339 R04340]
Reaction(KEGG)
Substrate
thiomorpholine 3-carboxylate [CPD:C03901];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
3,4-dehydro-thiomorpholine-3-carboxylate;
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The product is the cyclic imine of the 2-oxoacid corresponding to S-(2-aminoethyl)cysteine. In the reverse direction, a number of other cyclic unsaturated compounds can act as substrates, but more slowly.
Reference
1  [PMID:3371353]
  Authors
Nardini M, Ricci G, Caccuri AM, Solinas SP, Vesci L, Cavallini D.
  Title
Purification and characterization of a ketimine-reducing enzyme.
  Journal
Eur. J. Biochem. 173 (1988) 689-94.
  Organism
Sus scofa [GN:ssc]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
115232-54-7

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