KEGG   ENZYME: 1.5.1.25Help
Entry
EC 1.5.1.25                 Enzyme                                 

Name
thiomorpholine-carboxylate dehydrogenase;
ketimine reductase;
ketimine-reducing enzyme
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase
Reaction(IUBMB)
thiomorpholine 3-carboxylate + NAD(P)+ = 3,4-dehydro-thiomorpholine-3-carboxylate + NAD(P)H + H+ [RN:R04339 R04340]
Reaction(KEGG)
Substrate
thiomorpholine 3-carboxylate [CPD:C03901];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
3,4-dehydro-thiomorpholine-3-carboxylate;
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The product is the cyclic imine of the 2-oxoacid corresponding to S-(2-aminoethyl)cysteine. In the reverse direction, a number of other cyclic unsaturated compounds can act as substrates, but more slowly.
History
EC 1.5.1.25 created 1990
Orthology
K18258  
thiomorpholine-carboxylate dehydrogenase
Genes
HSA: 
1428(CRYM)
PTR: 
742586(CRYM)
PPS: 
100970861(CRYM)
GGO: 
101125433(CRYM)
PON: 
100454622(CRYM)
MCC: 
697588(CRYM)
MCF: 
102132895(CRYM)
MMU: 
12971(Crym)
RNO: 
117024(Crym)
CGE: 
100771156(Crym)
HGL: 
101706899(Crym)
TUP: 
102468903(CRYM)
CFA: 
479818(CRYM)
AML: 
FCA: 
101080756(CRYM)
PTG: 
102963483(CRYM)
BTA: 
505167(CRYM)
BOM: 
PHD: 
102326109(CRYM)
CHX: 
100861024(CRYM)
OAS: 
101102280(CRYM)
SSC: 
100525333(CRYM)
CFR: 
102507933(CRYM)
BACU: 
102999498(CRYM)
LVE: 
103071882(CRYM)
ECB: 
100057895(CRYM)
MYB: 
102263573(CRYM)
MYD: 
102759132(CRYM)
PALE: 
102893293(CRYM)
MDO: 
100019705(CRYM)
SHR: 
OAA: 
100087208(CRYM)
GGA: 
427008(CRYM)
MGP: 
TGU: 
100229846(CRYM)
FAB: 
101819247(CRYM)
PHI: 
102108632(CRYM)
APLA: 
101796429(CRYM)
FPG: 
101911191(CRYM)
FCH: 
102048264(CRYM)
CLV: 
102090474(CRYM)
ASN: 
102368044(CRYM)
AMJ: 
102562821(CRYM)
PSS: 
102459235(CRYM)
CMY: 
102942903(CRYM)
ACS: 
100561928(crym)
PBI: 
103066829(CRYM)
XLA: 
XTR: 
100125176(crym)
DRE: 
791205(crym)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102367345(CRYM)
CMK: 
103178740(crym)
BFO: 
CIN: 
SPU: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DYA: 
DGR: 
DMO: 
TCA: 
PHU: 
NVE: 
HMG: 
TAD: 
AQU: 
MBR: 
GBA: 
 » show all
Taxonomy
Reference
1  [PMID:3371353]
  Authors
Nardini M, Ricci G, Caccuri AM, Solinas SP, Vesci L, Cavallini D.
  Title
Purification and characterization of a ketimine-reducing enzyme.
  Journal
Eur. J. Biochem. 173 (1988) 689-94.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
115232-54-7

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