| Entry |
|
|---|
| Name |
1,2-dehydroreticulinium reductase (NADPH);
1,2-dehydroreticulinium ion reductase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
(R)-reticuline:NADP+ oxidoreductase |
|---|
| Reaction(IUBMB) |
(R)-reticuline + NADP+ = 1,2-dehydroreticulinium + NADPH + H+
[RN:R04695] |
|---|
| Reaction(KEGG) |
R04695
 |
|---|
| Substrate |
(R)-reticuline [CPD:C05178];
NADP+ [CPD:C00006] |
|---|
| Product |
1,2-dehydroreticulinium [CPD:C06167];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Comment |
Reduces the 1,2-dehydroreticulinium ion to (R)-reticuline, which is
a direct precursor of morphinan alkaloids in the poppy plant. The
enzyme does not catalyse the reverse reaction to any significant
extent under physiological conditions. |
|---|
| Pathway |
PATH: ec00950 Isoquinoline alkaloid biosynthesis
PATH: ec01063 Biosynthesis of alkaloids derived from shikimate
pathway
PATH: ec01100 Metabolic pathways |
|---|
Reference
Authors
Title
Journal
|
1
De-Eknamkul, W. and Zenk, M.H.
Purification and properties of 1,2-dehydroreticulinium reductase
from Papaver somniferum seedlings.
Phytochemistry 31 (1992) 813-821. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.5.1.27
IUBMB Enzyme Nomenclature: 1.5.1.27
ExPASy - ENZYME nomenclature database: 1.5.1.27
BRENDA, the Enzyme Database: 1.5.1.27
CAS: 130590-58-8 |
|---|
