| Entry |
|
|---|
| Name |
dihydrofolate reductase;
tetrahydrofolate dehydrogenase;
DHFR;
pteridine reductase:dihydrofolate reductase;
dihydrofolate reductase:thymidylate synthase;
thymidylate synthetase-dihydrofolate reductase;
folic acid reductase;
folic reductase;
dihydrofolic acid reductase;
dihydrofolic reductase;
7,8-dihydrofolate reductase;
NADPH-dihydrofolate reductase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase |
|---|
| Reaction(IUBMB) |
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+
[RN:R00939] |
|---|
| Reaction(KEGG) |
R00939;
(other) R00936 R00937 R00940 R02235 R02236
 |
|---|
| Substrate |
5,6,7,8-tetrahydrofolate [CPD:C00101];
NADP+ [CPD:C00006] |
|---|
| Product |
7,8-dihydrofolate [CPD:C00415];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Inhibitor |
Methotrexate [CPD:C01937];
Trimethoprim [CPD:C01965] |
|---|
| Comment |
The enzyme from animals and some micro-organisms also slowly reduces
folate to 5,6,7,8-tetrahydrofolate. |
|---|
| Pathway |
PATH: ec00670 One carbon pool by folate
PATH: ec00790 Folate biosynthesis
PATH: ec01061 Biosynthesis of phenylpropanoids
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00287 dihydrofolate reductase |
|---|
| Genes |
HSA: 1719(DHFR)
PTR: 460535(DHFRL1) 735442(DHFR)
MCC: 711268(DHFR)
MMU: 13361(Dhfr)
RNO: 24312(Dhfr)
CFA: 609048(DHFR)
BTA: 508809(DHFR)
ECB: 100073256
MDO: 100012354
GGA: 427317(DHFR)
TGU: 100229812
XLA: 495375
XTR: 733465(TNeu121j20.1)
DRE: 81882(dhfr)
CIN: 100182410 100187224
SPU: 575335
DME: Dmel_CG14887(Dhfr)
DPO: Dpse_GA13324
DAN: Dana_GF18503
DER: Dere_GG17010
DPE: Dper_GL22182
DSE: Dsec_GM15163
DSI: Dsim_GD19106
DYA: Dyak_GE24403
DGR: Dgri_GH19291
DMO: Dmoj_GI23507
AGA: AgaP_AGAP010278
AAG: AaeL_AAEL007370
CQU: CpipJ_CPIJ013529 CpipJ_CPIJ014417
AME: 410422
NVI: 100122177
API: 100161593(Acypi002804)
CEL: C36B1.7(dhfr-1)
CBR: CBG12356
BMY: Bm1_54930
SMM: Smp_175230
NVE: NEMVE_v1g210271
HMG: 100211347
TAD: TRIADDRAFT_52382
ATH: AT2G16370(THY-1)
OSA: 4350527(Os11g0484400)
OLU: OSTLU_49676 OSTLU_92087
CME: CMS462C
SCE: YOR236W(DFR1)
AGO: AGOS_ACR124W
KLA: KLLA0C07018g KLLA0D07458g
LTH: KLTH0D10802g
DHA: DEHA0C17688g
PIC: PICST_38512(FSH1) PICST_60284(FSH3) PICST_82622(DFR1)
PPA: PAS_chr1-4_0697
VPO: Kpol_1072p26
LEL: LELG_05210
ZRO: ZYRO0F06930g
CTP: CTRG_05212
CDU: CD36_72780(DFR1)
CGR: CAGL0J00385g CAGL0J03894g CAGL0L11044g
YLI: YALI0C12771g
SPO: SPCC1223.08c(dfr1)
PAN: PODANSg5354
FGR: FG07210.1
AFM: AFUA_2G08890 AFUA_3G06620
AOR: AO090020000337
ANG: An11g09680 An12g04590
AFV: AFLA_046100 AFLA_100800
PCS: Pc13g03650 Pc20g03140
NFI: NFIA_070630 NFIA_084470
CIM: CIMG_00470
URE: UREG_00509
SSL: SS1G_08803
BFU: BC1G_09253
CNE: CNJ01940
CNB: CNBJ1530
LBC: LACBIDRAFT_227877
UMA: UM03183.1 UM06281.1
MGL: MGL_3313
ECU: ECU08_0080
MBR: MONBRDRAFT_29079
DDI: DDB_0230113
PFA: PFD0805w
PYO: PY04370
TAN: TA08775
TPV: TP04_0504
CPV: cgd4_4460
CHO: Chro.40506
TET: TTHERM_00312120
TBR: Tb927.7.5480
TCR: 509153.90 510303.320
LMA: LmjF06.0860
TPS: THAPSDRAFT_261857
ECO: b0048(folA) b1606(folM)
ECJ: JW0047(folA)
ECD: ECDH10B_0049(folA)
EBW: BWG_0046(folA)
ECE: Z0055(folA)
ECS: ECs0051(folA)
ECF: ECH74115_0052(folA)
ETW: ECSP_0051(folA)
ECG: E2348C_0049(folA)
ECC: c0058(folA)
ECI: UTI89_C0054(folA)
ECP: ECP_0048(folA)
ECV: APECO1_1934(folA)
ECW: EcE24377A_0052(folA)
ECX: EcHS_A0054(folA)
ECM: EcSMS35_0050(folA) EcSMS35_A0121(dhfrV)
ECY: ECSE_0049(folA)
ECL: EcolC_3607(folA)
ECK: EC55989_0048(folA)
ECQ: ECED1_0047(folA)
ECR: ECIAI1_0050(folA)
ECT: ECIAI39_0049(folA)
ECZ: ECS88_0051(folA)
EUM: ECUMN_0050(folA)
ELF: LF82_0721(folA)
EBL: B21_00051(folA)
EBD: ECBD_3567
EBR: ECB_00052(folA)
EOH: ECO103_0051(folA)
EOI: ECO111_0049(folA)
EOJ: ECO26_0049(folA)
EFE: EFER_0056(folA)
STY: HCM1.165c(dhfR) HCM2.0117c STY0102(folA)
STT: t0090(folA)
SPT: SPA0088(folA)
SEK: SSPA0084(folA)
SPQ: SPAB_00112(folA)
SEI: SPC_0094(folA)
SEC: SC0082(folA) SC030(tri)
SEH: SeHA_C0093(folA)
SEE: SNSL254_A0092(folA)
SEW: SeSA_A0098(folA)
SEA: SeAg_B0096(folA)
SED: SeD_A0091(folA)
SEG: SG0089(folA)
SET: SEN0089(folA)
SES: SARI_02917(folA)
STM: STM0087(folA)
YPE: YPO0486(folA)
YPK: y3688(folA)
YPM: YP_3693(folA)
YPA: YPA_4079(folA)
YPN: YPN_0359(folA)
YPG: YpAngola_A0778(folA)
YPP: YPDSF_3147(folA)
YPS: YPTB0628(folA)
YPI: YpsIP31758_3449(folA)
YPY: YPK_3578(folA)
YPB: YPTS_0652(folA)
YEN: YE0626(folA)
SFL: SF0045(folA)
SFX: S0047(folA)
SFV: SFV_0042(folA)
SSN: SSON_0056(folA)
SBO: SBO_0037(folA)
SBC: SbBS512_E0042(folA)
SDY: SDY_0071(folA)
ECA: ECA3864(folA)
PCT: PC1_3641
PWA: Pecwa_3836
ETA: ETA_07210(folA)
PLU: plu0606(folA)
PAY: PAU_00564(folA)
BUC: BU143(folA)
BAS: BUsg136(folA)
BAB: bbp133(folA)
BAP: BUAP5A_141(folA)
BAU: BUAPTUC7_142(folA)
WBR: WGLp022(folA)
SGL: SG0421(folA)
ENT: Ent638_0597(folA)
ESA: ESA_03290(folA)
CTU: Ctu_06800(folA)
KPN: KPN_00045(folA)
KPE: KPK_4697(folA)
KPU: KP1_0858(folA)
CKO: CKO_03333(folA)
SPE: Spro_0720(folA)
PMR: PMI2337(folA)
EIC: NT01EI_0693
ETR: ETAE_0597(folA)
BFL: Bfl124(folA)
BPN: BPEN_128(folA)
HDE: HDEF_1626(folA)
DDA: Dd703_0599
DDC: Dd586_3577
DZE: Dd1591_0559
HIN: HI0899(folA)
HIT: NTHI1065(folA)
HIP: CGSHiEE_07515
HIQ: CGSHiGG_08055
HDU: HD1118(folA)
HAP: HAPS_0682(folA)
HSO: HS_0189(folA)
HSM: HSM_0057
PMU: PM1893(folA)
MSU: MS1858(folA)
APL: APL_0883(folA)
APJ: APJL_0895(folA)
APA: APP7_0942
ASU: Asuc_0714
AAP: NT05HA_1524
AAT: D11S_0018
XFA: XF2331
XFT: PD1363
XFM: Xfasm12_1503
XFN: XfasM23_1448
XCC: XCC0788(folA)
XCB: XC_3443
XCA: xccb100_3563
XCV: XCV0897(folA)
XAC: XAC0844(folA)
XOO: XOO3751(folA)
XOM: XOO_3541
XOP: PXO_04648(folA)
SML: Smlt0814(folA)
SMT: Smal_0664
VCH: VC0440
VCO: VC0395_A2858(folA)
VCM: VCM66_0425(folA)
VCJ: VCD_001166 VCD_003671
VVU: VV1_0666
VVY: VV0475
VPA: VP0333
VHA: VIBHAR_00805
VSP: VS_0367 VS_1884
VEX: VEA_001668
VFI: VF_0284(folA)
VFM: VFMJ11_0272(folA)
VSA: VSAL_I0366(folA)
PPR: PBPRA0399
PAE: PA0350(folA)
PAU: PA14_04580(folA)
PAP: PSPA7_0443(folA)
PAG: PLES_03471(folA)
PPU: PP_5132(folA)
PPF: Pput_5005
PPG: PputGB1_5184
PPW: PputW619_0333
PST: PSPTO_0437(folA)
PSB: Psyr_4737
PSP: PSPPH_4771(folA)
PFL: PFL_5883(folA)
PFO: Pfl01_5361
PFS: PFLU5803(folA)
PEN: PSEEN0273(folA)
PMY: Pmen_4209
PSA: PST_4017(folA)
CJA: CJA_0469(folA)
AVN: Avin_48110
PAR: Psyc_2012(folA)
PCR: Pcryo_2315
PRW: PsycPRwf_2332
ACI: ACIAD0514(folA)
ACB: A1S_0457
ABM: ABSDF3053(folA)
ABY: ABAYE3315(folA) ABAYE3614(dfrA10) ABAYE3644(dhfrI)
ABC: ACICU_00467
ABN: AB57_0540(folA)
ABB: ABBFA_003077
SON: SO_3646(folA)
SDN: Sden_2922
SFR: Sfri_3084
SAZ: Sama_2824
SBL: Sbal_0972
SBM: Shew185_1041
SBN: Sbal195_1074
SBP: Sbal223_3318
SLO: Shew_0874
SPC: Sputcn32_0984
SSE: Ssed_0959
SPL: Spea_0857
SHE: Shewmr4_0900
SHM: Shewmr7_3120
SHN: Shewana3_3214
SHW: Sputw3181_3183
SHL: Shal_0910
SWD: Swoo_1009
SWP: swp_4092
ILO: IL0478(folA)
CPS: CPS_4505(folA)
PHA: PSHAa2653(folA)
PAT: Patl_3735
SDE: Sde_0351
MAQ: Maqu_2431
AMC: MADE_03728
PIN: Ping_1045
TTU: TERTU_0366(folA)
CBU: CBU_1993(folA)
CBS: COXBURSA331_A0096(folA)
CBD: CBUD_2090(folA)
CBG: CbuG_2001(folA)
CBC: CbuK_2043(folA)
LPN: lpg0300
LPF: lpl0353(folA)
LPP: lpp0378(folA)
LPC: LPC_0379(folA)
MCA: MCA2729(folA)
FTU: FTT_0312c(folA)
FTF: FTF0312c(folA)
FTW: FTW_1770(folA)
FTL: FTL_0223
FTH: FTH_0218(folA)
FTA: FTA_0239(folA)
FTM: FTM_1540(folA)
FTN: FTN_0226(folA)
FPH: Fphi_0600
TCX: Tcr_0573
NOC: Noc_0235
AEH: Mlg_0423
HHA: Hhal_2048
TGR: Tgr7_2748
HNA: Hneap_0899 Hneap_1653
HCH: HCH_05856
CSA: Csal_2571
ABO: ABO_2343(folA)
MMW: Mmwyl1_3741
AHA: AHA_3377(folA)
ASA: ASA_0932(folA)
TAU: Tola_2373
DNO: DNO_0789(folA)
BCI: BCI_0561(folA)
RMA: Rmag_1019
VOK: COSY_0920(folA)
KKO: Kkor_2415
NMA: NMA2179
NME: NMB0308(folA)
NMC: NMC1873(folA)
NMN: NMCC_1836(folA)
NMI: NMO_1732(folA)
NGO: NGO1694
NGK: NGK_2087
CVI: CV_1028(folA)
LHK: LHK_00787
RSO: RSc0946(folA)
RPI: Rpic_0817
RPF: Rpic12D_0888
REU: Reut_A0914
REH: H16_A2704(folA2)
RME: Rmet_2569
CTI: RALTA_A2195(folA)
BMA: BMA0387(folA)
BMV: BMASAVP1_A2530(folA)
BML: BMA10229_A0903(folA)
BMN: BMA10247_0244(folA)
BPS: BPSL2476
BPM: BURPS1710b_2952(folA)
BPL: BURPS1106A_2902(folA)
BPD: BURPS668_2842(folA)
BPR: GBP346_A3022(folA)
BTE: BTH_I1674
BVI: Bcep1808_1002
BUR: Bcep18194_A4196
BCN: Bcen_0603
BCH: Bcen2424_1082
BCM: Bcenmc03_1041
BCJ: BCAL2915(dfrA)
BAM: Bamb_0958
BAC: BamMC406_0962
BMU: Bmul_2221
BMJ: BMULJ_01018(folA)
BXE: Bxe_A1020 Bxe_B1926
BPH: Bphy_0782
BPY: Bphyt_2964
BGL: bglu_1g09160
PNU: Pnuc_0380
PNE: Pnec_0386
BPE: BP3155(folA)
BPA: BPP0786(folA)
BBR: BB0871(folA)
BPT: Bpet4035(folA)
BAV: BAV0506(folA)
RFR: Rfer_2985
POL: Bpro_1822
PNA: Pnap_2773
AAV: Aave_1448
AJS: Ajs_1195
VEI: Veis_3173
DAC: Daci_4971
DIA: Dtpsy_1115
VAP: Vapar_1663
CTT: CtCNB1_3259
MPT: Mpe_A2052 Mpe_B0221
HAR: HEAR1055(folA)
MMS: mma_1192(folA)
LCH: Lcho_1259
NEU: NE0567(dfrA)
NET: Neut_1020
NMU: Nmul_A1963
EBA: ebA4414(dfrA)
AZO: azo3198(folA)
DAR: Daro_0579
TMZ: Tmz1t_1591
TBD: Tbd_2039
MFA: Mfla_0914 Mfla_1058
MMB: Mmol_1530
MEI: Msip34_0885
APP: CAP2UW1_0562
GSU: GSU0571(folA)
GME: Gmet_2947
GUR: Gura_0932
GEO: Geob_1750
PCA: Pcar_2754(folA)
BBA: Bd3231(folA)
DPS: DP0311
MXA: MXAN_5943(folA)
HOH: Hoch_5413
RCO: RC0034(folA)
RFE: RF_0037 RF_0038
RAK: A1C_00205
RRI: A1G_00215
RRJ: RrIowa_0047
RAF: RAF_ORF0031(folA)
RBE: RBE_0033(folA)
RBO: A1I_00175
WOL: WD0884(folA)
WRI: WRi_008610(folA)
WPI: WPa_0694(folA)
MLO: mll1457
MES: Meso_1750
PLA: Plav_2449
SME: SMc01442(folA)
SMD: Smed_2019
ATU: Atu2046(folA)
ATC: AGR_C_3708
ARA: Arad_2910(folA)
AVI: Avi_2819(folA)
RET: RHE_CH02798(folA)
REC: RHECIAT_CH0002941(folA)
RLE: RL3255(folA)
RLT: Rleg2_2542
RLG: Rleg_2801
RHI: NGR_c20290(folA)
LAS: CLIBASIA_04280
BME: BMEI0609
BMF: BAB1_1417(folA)
BMB: BruAb1_1393(folA)
BMC: BAbS19_I13240
BMS: BR1398(folA)
BMT: BSUIS_A1449
BOV: BOV_1354(folA)
BCS: BCAN_A1430
BMR: BMI_I1409(folA)
OAN: Oant_1793
BJA: bll6510(folA)
BRA: BRADO5576(folA)
BBT: BBta_6098(folA)
RPA: RPA3492(dyr)
RPB: RPB_2037
RPC: RPC_3263
RPD: RPD_3353
RPE: RPE_2177
RPT: Rpal_4006
NWI: Nwi_2350
NHA: Nham_2729
OCA: OCAR_5277(folA)
BHE: BH10970(folA)
BQU: BQ08620(folA)
BBK: BARBAKC583_0925(folA)
BTR: Btr_1567(folA)
BGR: Bgr_13720(folA)
XAU: Xaut_1420
AZC: AZC_4483
MEX: Mext_2659 Mext_3930
MEA: Mex_1p2852(dfrA) Mex_1p4312(dmrA)
MDI: METDI3418(dfrA) METDI4922(dmrA)
MRD: Mrad2831_3892 Mrad2831_4526
MET: M446_1090 M446_2602
MPO: Mpop_2781 Mpop_4405
MCH: Mchl_2886 Mchl_4298
MNO: Mnod_0700 Mnod_4627
BID: Bind_1729
MSL: Msil_0603 Msil_2640
CCR: CC_2126
CCS: CCNA_02210
CAK: Caul_3387
PZU: PHZ_c0817(folA)
SIT: TM1040_1728
RSP: RSP_0389(folA)
RSH: Rsph17029_2043
RSQ: Rsph17025_0847
RSK: RSKD131_1718
RDE: RD1_1875(folA)
MMR: Mmar10_2025
HNE: HNE_0463(folA)
HBA: Hbal_0457
ZMO: ZMO0321
ZMN: Za10_0911
NAR: Saro_3262
SAL: Sala_2360
SWI: Swit_3786
ELI: ELI_13570
GBE: GbCGDNIH1_1342
RCE: RC1_1989(folA)
MAG: amb1326
BSU: BSU21810(dfrA)
BHA: BH3450(dfrA)
BAN: BA2237(dfrA)
BAR: GBAA2237(dfrA)
BAA: BA_2741
BAT: BAS2083
BAH: BAMEG_2357(dfrA)
BAI: BAA_2301(dfrA)
BCE: BC2192
BCA: BCE_2267(dfrA)
BCZ: BCZK2021(dfrA)
BCR: BCAH187_A2349(dfrA)
BCB: BCB4264_A2220(dfrA)
BCU: BCAH820_2264(dfrA)
BCG: BCG9842_B3104(dfrA)
BCQ: BCQ_2175(dfrA)
BCX: BCA_2322(dfrA)
BCY: Bcer98_1640
BTK: BT9727_2021(dfrA)
BTL: BALH_2001
BWE: BcerKBAB4_2062
BLI: BL03300(dfrA)
BLD: BLi02319(dfrA)
BCL: ABC2954(dfrA)
BAY: RBAM_019960(dfrA)
BPU: BPUM_1915(dfrA)
OIH: OB1739(dfrA)
GKA: GK1775
GTN: GTNG_1670
GWC: GWCH70_1582
GYM: GYMC10_2406
GYC: GYMC61_2588
AFL: Aflv_1454(dfrA)
SAU: SA1259(dfrA)
SAV: SAV1426(dfrA)
SAW: SAHV_1414(dfrA)
SAM: MW1316(dfrA)
SAR: SAR1439(dfrB)
SAS: SAS1369
SAC: SACOL1461(folA)
SAB: SAB1281c(dfrB)
SAA: SAUSA300_1319(folA)
SAX: USA300HOU_1363(dfrB)
SAO: SAOUHSC_01434
SAJ: SaurJH9_1486
SAH: SaurJH1_1515
SAE: NWMN_1337(dfrA)
SAD: SAAV_1409(folA)
SEP: SE1119
SER: SERP1002(folA-1) SERP1581(folA-2)
SHA: SH1480(dfrA)
SSP: SSP1313
SCA: Sca_1070(dfrA)
LMO: lmo1873
LMF: LMOf2365_1903(folA)
LMH: LMHCC_0683(folA)
LMC: Lm4b_01890
LIN: lin1987
LWE: lwe1893(dfrA)
LSP: Bsph_2724
ESI: Exig_1742
EAT: EAT1b_0140
MCL: MCCL_1077(dfrB) MCCL_plsB0051
BBE: BBR47_43870(folA)
PJD: Pjdr2_2656
LLA: L162872(dfrA)
LLK: LLKF_1175(dfrA)
LLC: LACR_1270
LLM: llmg_1342(dfrA)
SPY: SPy_0883(dyr)
SPZ: M5005_Spy_0689(dyr)
SPM: spyM18_0944(dfr)
SPG: SpyM3_0602(dyr)
SPS: SPs1251
SPH: MGAS10270_Spy0747(dyr)
SPI: MGAS10750_Spy0781(dyr)
SPJ: MGAS2096_Spy0761(dyr)
SPK: MGAS9429_Spy0745(dyr)
SPF: SpyM51119(dfrB)
SPA: M6_Spy0706
SPB: M28_Spy0669(dyr)
SOZ: Spy49_0697(dyr)
SPN: SP_1571
SPD: SPD_1401(folA)
SPR: spr1429(dfr)
SPW: SPCG_1556(dfr)
SPX: SPG_1497(folA)
SNE: SPN23F_15880(dyr)
SPV: SPH_1685(folA)
SNM: SP70585_1612(folA)
SJJ: SPJ_1477(folA)
SPP: SPP_1594(folA)
SNT: SPT_1511(folA)
SAG: SAG1314(folA)
SAN: gbs1384(dfrA)
SAK: SAK_1345(folA)
SMU: SMU.947(dfrA)
STC: str0579(folA)
STL: stu0579(folA)
STE: STER_0623
SSA: SSA_1092(dfrA)
SSU: SSU05_0835
SSV: SSU98_0835
SSB: SSUBM407_0957 SSUBM407_1056(dyr)
SSI: SSU0779(dyr)
SSS: SSUSC84_0742(dyr)
SGO: SGO_0348 SGO_1141(folA)
SEQ: SZO_08900
SEZ: Sez_1077(dhfR)
SEU: SEQ_1111
SUB: SUB0772(dyr)
SDS: SDEG_0846(dyr)
LPL: lp_1869(dfrA)
LPJ: JDM1_1571(dfrA)
LJO: LJ1470
LJF: FI9785_797(dfrA)
LAC: LBA0902(dfrA)
LSA: LSA1000(dfrA)
LSL: LSL_0709(folA)
LDB: Ldb0788(folA)
LBU: LBUL_0721
LBR: LVIS_0785
LCA: LSEI_1388
LCB: LCABL_16080(folA)
LGA: LGAS_0831
LRE: Lreu_0770
LRF: LAR_0740
LHE: lhv_0956
LFE: LAF_0888
LRH: LGG_01398(dfrA)
LRL: LC705_01414(dfrA)
PPE: PEPE_1069
EFA: EF1577(folA)
OOE: OEOE_1013
LME: LEUM_0757
LCI: LCK_00692(folA)
CAC: CAC3004(folA)
CPE: CPE0044(folA)
CPF: CPF_0051(folA)
CPR: CPR_0054(folA)
CNO: NT01CX_1208(folA)
CTH: Cthe_1226
CDC: CD196_0056
CDL: CDR20291_0044
CBK: CLL_A3449(folA)
CBT: CLH_3228(folA)
CBE: Cbei_4953
CKL: CKL_2200(dfrD)
CKR: CKR_1935
CCE: Ccel_1310
STH: STH3116
VPR: Vpar_1384
FMA: FMG_0268
APR: Apre_1626
EEL: EUBELI_01270 EUBELI_01781
ERE: EUBREC_1249
MGE: MG_228(dhfR)
MPN: MPN321(dhfR)
MPU: MYPU_5370(dhfR)
MPE: MYPE6860(dhfR)
MMO: MMOB0350(dhfR)
MSY: MS53_0397(folA)
UUR: UU114(folA)
UPA: UPA3_0119(folA)
UUE: UUR10_0127(folA)
POY: PAM294(folA)
AYW: AYWB_429(folA)
PML: ATP_00321(folA)
PAL: PAa_0085(folA)
ACL: ACL_0690(folA)
MFL: Mfl383
MTU: Rv2763c(dfrA)
MTC: MT2833(folA)
MRA: MRA_2788(dfrA)
MTF: TBFG_12776
MTB: TBMG_01212(TBMG_01212.1)
MBO: Mb2785c(dfrA)
MBB: BCG_2780c(dfrA)
MBT: JTY_2774(dfrA)
MLE: ML1518(folA)
MLB: MLBr_01518(folA)
MPA: MAP2868c(dfrA)
MAV: MAV_3651(folA)
MSM: MSMEG_2671(folA)
MUL: MUL_2179(dfrA)
MVA: Mvan_2381
MGI: Mflv_4006
MAB: MAB_3090c
MMC: Mmcs_2113
MKM: Mkms_2159
MJL: Mjls_2100
MMI: MMAR_1957(dfrA)
CGL: NCgl0809(cgl0843)
CGB: cg0965(folA)
CGT: cgR_0958
CEF: CE0918
CDI: DIP0824
CJK: jk0440(folA)
CUR: cur_1521
CAR: cauri_0791(folA)
CKP: ckrop_0460(folA)
NFA: nfa50230(dfrA)
RHA: RHA1_ro02249
RER: RER_44620(folA)
ROP: ROP_19630(folA)
GBR: Gbro_2177
LXX: Lxx09920(folA)
ART: Arth_3019
AAU: AAur_2993(folA)
ACH: Achl_2731 Achl_3945
RSA: RSal33209_0957
KRH: KRH_05680(folA)
MLU: Mlut_17470
BCV: Bcav_2865
BFA: Bfae_29380
JDE: Jden_1031
XCE: Xcel_2833
PAC: PPA1671
NCA: Noca_2312
SRO: Sros_4921
KRA: Krad_4438
BLO: BL1666(dfrA)
BLJ: BLD_1790(folA)
BLN: Blon_2141
BAD: BAD_0389(dfrA)
BLA: BLA_0435(dfrA)
BLC: Balac_0458
BLT: Balat_0458
APV: Apar_0631
CTR: CT612(folA)
CTA: CTA_0665(folA)
CTB: CTL0876(folA)
CTL: CTLon_0870(folA)
CTJ: JALI_6161(folA)
CMU: TC0902(folA)
CPN: CPn0759(folA)
CPA: CP1113
CPJ: CPj0759(folA)
CPT: CpB0787
CCA: CCA00998(folA)
CAB: CAB968(folA)
CFE: CF0015(folA)
BHY: BHWA1_00172(folA)
BTH: BT_2048
BFR: BF3735
BFS: BF3524(dfrA)
BVU: BVU_1949
PGI: PG2061(folA)
PGN: PGN_2061
PDI: BDI_3748
APS: CFPG_509
SRU: SRU_0412(folA)
RMR: Rmar_0341
CHU: CHU_0402(folA) CHU_1297(dfr) CHU_1569(folA) CHU_1753(dfr)
CHU_2397(folA) CHU_2917(folA) CHU_3049(dfr)
DFE: Dfer_4255 Dfer_4811
CPI: Cpin_6452
PHE: Phep_1421
GFO: GFO_0279(dfrA)
FJO: Fjoh_1468
FPS: FP0328(dfrA)
FBA: FIC_02181
COC: Coch_0487
RBI: RB2501_03245
BBL: BLBBGE_449(folA)
BPI: BPLAN_191(folA)
AAS: Aasi_0300
FSU: Fisuc_0020
FNU: FN0241
LBA: Lebu_0682
STR: Sterm_1610
SMF: Smon_0989
OTE: Oter_2446
AMU: Amuc_2031
RBA: RB12617(folA)
GVI: glr2476
DRA: DR_2632
DDR: Deide_23020(dfrA)
TMA: TM1641
TPT: Tpet_1150
TRQ: TRQ2_1305
TNA: CTN_0817
TNP: Tnap_1165
TME: Tmel_0646
TAF: THA_624(folA)
FNO: Fnod_1542
PMO: Pmob_0026
KOL: Kole_2036
HMA: pNG7359(folA2) rrnAC0859(folA1)
HWA: HQ1842A(folA) HQ2455A(folA)
NPH: NP2922A(folA)
HLA: Hlac_0438 Hlac_2167
HMU: Hmuk_1491 Hmuk_3007
 |
|---|
| Structures |
PDB: 1AI9 1AO8 1AOE 1BOZ 1BZF 1CD2 1CZ3 1D1G 1DAJ 1DDR
1DDS 1DF7 1DG5 1DG7 1DG8 1DHF 1DHI 1DHJ 1DIS 1DIU
1DLR 1DLS 1DR1 1DR2 1DR3 1DR4 1DR5 1DR6 1DR7 1DRA
1DRB 1DRE 1DRF 1DRH 1DYH 1DYI 1DYJ 1DYR 1E26 1HFP
1HFQ 1HFR 1IA1 1IA2 1IA3 1IA4 1J3I 1J3J 1J3K 1JOL
1JOM 1JUV 1KLK 1KMS 1KMV 1LUD 1LY3 1LY4 1M78 1M79
1M7A 1MVS 1MVT 1OHJ 1OHK 1PD8 1PD9 1PDB 1QZF 1RA1
1RA2 1RA3 1RA8 1RA9 1RB2 1RB3 1RC4 1RD7 1RE7 1RF7
1RG7 1RH3 1RX1 1RX2 1RX3 1RX4 1RX5 1RX6 1RX7 1RX8
1RX9 1S3U 1S3V 1S3W 1S3Y 1SEJ 1TDR 1U70 1U71 1U72
1VDR 1VIE 1VIF 1VJ3 1YHO 1ZDR 2ANO 2ANQ 2BL9 2BLA
2BLB 2BLC 2C2S 2C2T 2CD2 2CIG 2D0K 2DHF 2DRC 2FZH
2FZI 2FZJ 2GQV 2H2Q 2HM9 2HQP 2INQ 2ITH 2JYB 2OIP
2P4T 2QK8 2RH2 2RK1 2RK2 2W3A 2W3B 2W3M 2W3V 2W3W
2W9G 2W9H 2W9S 2W9T 3CD2 3CL9 3CLB 3CSE 3D80 3D84
3DAT 3DAU 3DFR 3DG8 3DGA 3DL5 3DL6 3DRC 3E0B 3EIG
3F0B 3F0Q 3F0S 3F0U 3F0V 3F0X 3F8Y 3F8Z 3F91 3FL8
3FL9 3FQ0 3FQC 3FQF 3FQO 3FQV 3FQZ 3FRA 3FRB 3FRD
3FRE 3FRF 3FS6 3FY8 3FY9 3FYV 3FYW 3GHC 3GHV 3GHW
3GI2 3GYF 3HBB 3IA4 3IA5 3K45 3K47 4CD2 4DFR 5DFR
6DFR 7DFR 8DFR |
|---|
Reference
Authors
Title
Journal
|
1
Blakley, R.L. and MacDougall, B.M.
Dihydrofolic reductase from Streptococcus faecalis R.
J. Biol. Chem. 236 (1961) 1163. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:6815178]
Bolin JT, Filman DJ, Matthews DA, Hamlin RC, Kraut J.
Crystal structures of Escherichia coli and Lactobacillus casei
dihydrofolate reductase refined at 1.7 A resolution. I. General
features and binding of methotrexate.
J. Biol. Chem. 257 (1982) 13650-62.
Escherichia coli [GN:eco], Lactobacillus casei [GN:lca] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:4379915]
Kaufman BT, Gardiner RC.
Studies on dihydrofolic reductase. I. Purification and properties of
dihydrofolic reductase from chicken liver.
J. Biol. Chem. 241 (1966) 1319-28.
Gallus gallus [GN:gga] |
|---|
Reference
Authors
Title
Journal
|
4 [PMID:4306838]
Young IG, Gibson F.
Regulation of the enzymes involved in the biosynthesis of
2,3-dihydroxybenzoic acid in Aerobacter aerogenes and Escherichia
coli.
Biochim. Biophys. Acta. 177 (1969) 401-11. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.5.1.3
IUBMB Enzyme Nomenclature: 1.5.1.3
ExPASy - ENZYME nomenclature database: 1.5.1.3
BRENDA, the Enzyme Database: 1.5.1.3
CAS: 9002-03-3 |
|---|
