KEGG   ENZYME: 1.5.1.33Help
Entry
EC 1.5.1.33                 Enzyme                                 

Name
pteridine reductase;
PTR1;
pteridine reductase 1
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase
Reaction(IUBMB)
5,6,7,8-tetrahydrobiopterin + 2 NADP+ = biopterin + 2 NADPH + 2 H+ [RN:R01812]
Reaction(KEGG)
Substrate
5,6,7,8-tetrahydrobiopterin [CPD:C00272];
NADP+ [CPD:C00006]
Product
biopterin [CPD:C06313];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme from Leishmania (both amastigote and promastigote forms) catalyses the reduction by NADPH of folate and a wide variety of unconjugated pterins, including biopterin, to their tetrahydro forms. It also catalyses the reduction of 7,8-dihydropterins and 7,8-dihydrofolate to their tetrahydro forms. In contrast to EC 1.5.1.3 (dihydrofolate reductase) and EC 1.5.1.34 (6,7-dihydropteridine reductase), pteridine reductase will not catalyse the reduction of the quinonoid form of dihydrobiopterin. The enzyme is specific for NADPH; no activity has been detected with NADH. It also differs from EC 1.5.1.3 (dihydrofolate reductase) in being specific for the Si-face of NADPH.
History
EC 1.5.1.33 created 1999 as EC 1.1.1.253, transferred 2003 to EC 1.5.1.33
Orthology
K03793  
pteridine reductase
Genes
BFO: 
AQU: 
RCU: 
TBR: 
Tb927.8.2210(Tb08.26N11.790)
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
PLU: 
XFA: 
XFT: 
PD0677(ptr1)
XFM: 
XFN: 
XFF: 
XCC: 
XCC3431(ptr1)
XCB: 
XCA: 
XCP: 
XCV: 
XAC: 
XAC0688(ptr1)
XCI: 
XAX: 
XACM_0692(ptr1)
XAO: 
XOO: 
XOO3932(ptr1)
XOM: 
XOP: 
XOR: 
XAL: 
XFU: 
SML: 
SMT: 
BUJ: 
SMZ: 
PSU: 
PSD: 
FAU: 
RHD: 
DJI: 
CJA: 
PAR: 
PCR: 
PSO: 
MCT: 
SAZ: 
SLO: 
SPL: 
SHL: 
SWP: 
SVO: 
PAT: 
SDE: 
MAQ: 
MHC: 
MAD: 
AMC: 
AMAC: 
AMB: 
AMG: 
AMH: 
AMK: 
AMAA: 
AMAL: 
AMAE: 
AMAO: 
AMAD: 
AMAI: 
AMAG: 
ALT: 
GAG: 
GPS: 
TTU: 
FBL: 
LPN: 
LPH: 
LPV_3220(phaB)
LPO: 
LPO_3167(phaB)
LPU: 
LPM: 
LPF: 
LPP: 
LPC: 
LPC_3148(phaB)
LPA: 
LPE: 
LLO: 
LLO_0172(phaB)
MCA: 
MMT: 
MAH: 
CYQ: 
CZA: 
TMB: 
TGR: 
TKM: 
TNI: 
ABO: 
ADI: 
OCE: 
AFE: 
AFR: 
ACU: 
AFI: 
RMA: 
CVI: 
LHK: 
PSE: 
NEU: 
NET: 
NIT: 
NII: 
NMU: 
EBA: 
AZO: 
AZA: 
TMZ: 
DSU: 
TBD: 
SDR: 
MFA: 
MMB: 
MEH: 
MEI: 
MEP: 
MPQ_0259(fabG)
APP: 
SLT: 
GCA: 
ADE: 
ACP: 
AFW: 
ANK: 
MXA: 
MFU: 
CCX: 
COCOR_07451(fabG13)
SUR: 
SCL: 
SCU: 
SBU: 
SGP: 
ACM: 
GAU: 
GBA: 
PBS: 
IPA: 
SACI: 
RCA: 
CAP: 
 » show all
Taxonomy
Reference
1  [PMID:9153248]
  Authors
Nare B, Hardy LW, Beverley SM.
  Title
The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major.
  Journal
J. Biol. Chem. 272 (1997) 13883-91.
  Organism
Leishmania major
  Sequence
Reference
2  [PMID:11373620]
  Authors
Gourley DG, Schuttelkopf AW, Leonard GA, Luba J, Hardy LW, Beverley SM, Hunter WN.
  Title
Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites.
  Journal
Nat. Struct. Biol. 8 (2001) 521-5.
  Organism
Leishmania major
  Sequence
Reference
3  [PMID:10800597]
  Authors
Fitzpatrick PF.
  Title
The aromatic amino acid hydroxylases.
  Journal
Adv. Enzymol. Relat. Areas. Mol. Biol. 74 (2000) 235-94.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
131384-61-7

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