| Entry |
|
|---|
| Name |
formyltetrahydrofolate dehydrogenase;
10-formyl tetrahydrofolate:NADP oxidoreductase;
10-formyl-H2PtGlu:NADP oxidoreductase ;
10-formyl-H4folate dehydrogenase;
N10-formyltetrahydrofolate dehydrogenase ;
10-formyltetrahydrofolate dehydrogenase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
10-formyltetrahydrofolate:NADP+ oxidoreductase |
|---|
| Reaction(IUBMB) |
10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 +
NADPH + H+ [RN:R00941] |
|---|
| Reaction(KEGG) |
R00941
 |
|---|
| Substrate |
10-formyltetrahydrofolate [CPD:C00234];
NADP+ [CPD:C00006];
H2O [CPD:C00001] |
|---|
| Product |
tetrahydrofolate [CPD:C00101];
CO2 [CPD:C00011];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Pathway |
PATH: ec00670 One carbon pool by folate |
|---|
| Orthology |
KO: K00289 formyltetrahydrofolate dehydrogenase |
|---|
| Genes |
HSA: 10840(ALDH1L1)
PTR: 460655(ALDH1L1)
MCC: 716977
MMU: 107747(Aldh1l1)
RNO: 64392(Aldh1l1)
CFA: 476506(ALDH1L1)
BTA: 505677(ALDH1L1)
SSC: 100151976
ECB: 100061108
XLA: 444321
XTR: 496436(TNeu011l01.1)
DRE: 798292
DME: Dmel_CG8665
DPO: Dpse_GA21245
CEL: F36H1.6(alh-3)
NVE: NEMVE_v1g200699
 |
|---|
| Structures |
PDB: 1S3I 2BW0 2CFI 2CQ8 2O2P 2O2Q 2O2R |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4384443]
Kutzbach C, Stokstad EL.
Partial purification of a 10-formyl-tetrahydrofolate: NADP
oxidoreductase from mammalian liver.
Biochem. Biophys. Res. Commun. 30 (1968) 111-7.
Bos taurus [GN:bta] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.5.1.6
IUBMB Enzyme Nomenclature: 1.5.1.6
ExPASy - ENZYME nomenclature database: 1.5.1.6
BRENDA, the Enzyme Database: 1.5.1.6
CAS: 37256-25-0 |
|---|
