| Entry |
|
|---|
| Name |
saccharopine dehydrogenase (NADP+, L-lysine-forming);
lysine-2-oxoglutarate reductase;
lysine-ketoglutarate reductase;
L-lysine-alpha-ketoglutarate reductase;
lysine:alpha-ketoglutarate:TPNH oxidoreductase
(epsilon-N-[gultaryl-2]-L-lysine forming);
saccharopine (nicotinamide adenine dinucleotide phosphate,
lysine-forming) dehydrogenase;
6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase
(L-lysine-forming) |
|---|
| Class |
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase
(L-lysine-forming) |
|---|
| Reaction(IUBMB) |
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-lysine +
2-oxoglutarate + NADPH + H+ [RN:R00716] |
|---|
| Reaction(KEGG) |
R00716
 |
|---|
| Substrate |
N6-(L-1,3-dicarboxypropyl)-L-lysine [CPD:C00449];
NADP+ [CPD:C00006];
H2O [CPD:C00001] |
|---|
| Product |
L-lysine [CPD:C00047];
2-oxoglutarate [CPD:C00026];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Pathway |
PATH: ec00300 Lysine biosynthesis
PATH: ec00310 Lysine degradation
PATH: ec01064 Biosynthesis of alkaloids derived from ornithine,
lysine and nicotinic acid
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00291 saccharopine dehydrogenase (NADP+, L-lysine forming) |
|---|
| Genes |
HSA: 10157(AASS)
MMU: 30956(Aass)
ATH: AT4G33150
TET: TTHERM_00149450
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4385118]
Hutzler J, Dancis J.
Conversion of lysine to saccharopine by human tissues.
Biochim. Biophys. Acta. 158 (1968) 62-9.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:6434529]
Markovitz PJ, Chuang DT, Cox RP.
Familial hyperlysinemias. Purification and characterization of the
bifunctional aminoadipic semialdehyde synthase with
lysine-ketoglutarate reductase and saccharopine dehydrogenase
activities.
J. Biol. Chem. 259 (1984) 11643-6.
Bos taurus [GN:bta], Papio sp. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.5.1.8
IUBMB Enzyme Nomenclature: 1.5.1.8
ExPASy - ENZYME nomenclature database: 1.5.1.8
BRENDA, the Enzyme Database: 1.5.1.8
CAS: 9031-19-0 |
|---|
