KEGG   ENZYME: 1.5.1.8Help
Entry
EC 1.5.1.8                  Enzyme                                 

Name
saccharopine dehydrogenase (NADP+, L-lysine-forming);
lysine-2-oxoglutarate reductase;
lysine-ketoglutarate reductase;
L-lysine-alpha-ketoglutarate reductase;
lysine:alpha-ketoglutarate:TPNH oxidoreductase (epsilon-N-[gultaryl-2]-L-lysine forming);
saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming) dehydrogenase;
6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)
Reaction(IUBMB)
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-lysine + 2-oxoglutarate + NADPH + H+ [RN:R00716]
Reaction(KEGG)
Substrate
N6-(L-1,3-dicarboxypropyl)-L-lysine [CPD:C00449];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
L-lysine [CPD:C00047];
2-oxoglutarate [CPD:C00026];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.5.1.8 created 1972
Pathway
Lysine degradation
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K00291  
saccharopine dehydrogenase (NADP+, L-lysine forming)
K14157  
alpha-aminoadipic semialdehyde synthase
Genes
HSA: 
10157(AASS)
PTR: 
472493(AASS)
PPS: 
100983928(AASS)
GGO: 
101143865(AASS)
PON: 
100454072(AASS)
MCC: 
694594(AASS)
MCF: 
102145151(AASS)
MMU: 
30956(Aass)
RNO: 
296925(Aass)
CGE: 
100751161(Aass)
HGL: 
101707268(Aass)
TUP: 
102489208(AASS)
CFA: 
482429(AASS)
AML: 
FCA: 
101091272(AASS)
PTG: 
102960744(AASS)
BTA: 
520865(AASS)
BOM: 
102275417(AASS)
PHD: 
102322901(AASS)
CHX: 
102185894(AASS)
SSC: 
100513962(AASS)
CFR: 
102520837(AASS)
BACU: 
103016134(AASS)
LVE: 
103085872(AASS)
ECB: 
100056260(AASS)
MYB: 
102254732(AASS)
MYD: 
102770634(AASS)
PALE: 
102881018(AASS)
MDO: 
100016400(AASS)
SHR: 
100923009(AASS)
OAA: 
100076030(AASS)
GGA: 
417757(AASS)
MGP: 
TGU: 
100222251(AASS)
FAB: 
101818954(AASS)
PHI: 
102112915(AASS)
APLA: 
101793380(AASS)
FPG: 
101923487(AASS)
FCH: 
102047696(AASS)
CLV: 
102094241(AASS)
ASN: 
102376316(AASS)
AMJ: 
102574453(AASS)
PSS: 
102454542(AASS)
CMY: 
102948389(AASS)
ACS: 
PBI: 
XLA: 
444409(aass)
XTR: 
496923(aass)
DRE: 
556229(aass)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102353181(AASS)
CMK: 
103179368(aass)
BFO: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
552130(LKR)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_R02D3.1(R02D3.1)
CBR: 
NVE: 
HMG: 
TAD: 
AQU: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
CSV: 
RCU: 
POP: 
VVI: 
SLY: 
SOT: 
DOSA: 
Os02t0783700-01(Os02g0783700)
OBR: 
BDI: 
SBI: 
SORBI_04g035220(SORBIDRAFT_04g035220)
ZMA: 
541648(lkrsdh1)
SITA: 
ATR: 
s00129p00051020(AMTR_s00129p00051020)
SMO: 
PPP: 
GSL: 
CNE: 
CNB: 
CGI: 
LBC: 
CCI: 
SCM: 
MBR: 
DDI: 
DPP: 
DFA: 
DFA_03752(aass)
TET: 
PTI: 
TPS: 
PIF: 
EHX: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:4385118]
  Authors
Hutzler J, Dancis J.
  Title
Conversion of lysine to saccharopine by human tissues.
  Journal
Biochim. Biophys. Acta. 158 (1968) 62-9.
  Organism
Homo sapiens
Reference
2  [PMID:6434529]
  Authors
Markovitz PJ, Chuang DT, Cox RP.
  Title
Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities.
  Journal
J. Biol. Chem. 259 (1984) 11643-6.
  Organism
Bos taurus, Papio sp.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9031-19-0

KEGG   ENZYME: 1.5.1.9Help
Entry
EC 1.5.1.9                  Enzyme                                 

Name
saccharopine dehydrogenase (NAD+, L-glutamate-forming);
dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming);
saccharopin dehydrogenase;
NAD+ oxidoreductase (L-2-aminoadipic-delta-semialdehyde and glutamate forming);
aminoadipic semialdehyde synthase;
6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)
Reaction(IUBMB)
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADH + H+ [RN:R02313]
Reaction(KEGG)
Substrate
N6-(L-1,3-dicarboxypropyl)-L-lysine [CPD:C00449];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
L-glutamate [CPD:C00025];
(S)-2-amino-6-oxohexanoate [CPD:C04076];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The activities of this enzyme along with EC 1.5.1.8, saccharopine dehydrogenase (NADP+, L-lysine-forming), occur on a single protein.
History
EC 1.5.1.9 created 1972, modified 2011
Pathway
Lysine degradation
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K00292  
saccharopine dehydrogenase (NAD+, L-glutamate forming)
K14157  
alpha-aminoadipic semialdehyde synthase
Genes
HSA: 
10157(AASS)
PTR: 
472493(AASS)
PPS: 
100983928(AASS)
GGO: 
101143865(AASS)
PON: 
100454072(AASS)
MCC: 
694594(AASS)
MCF: 
102145151(AASS)
MMU: 
30956(Aass)
RNO: 
296925(Aass)
CGE: 
100751161(Aass)
HGL: 
101707268(Aass)
TUP: 
102489208(AASS)
CFA: 
482429(AASS)
AML: 
FCA: 
101091272(AASS)
PTG: 
102960744(AASS)
BTA: 
520865(AASS)
BOM: 
102275417(AASS)
PHD: 
102322901(AASS)
CHX: 
102185894(AASS)
SSC: 
100513962(AASS)
CFR: 
102520837(AASS)
BACU: 
103016134(AASS)
LVE: 
103085872(AASS)
ECB: 
100056260(AASS)
MYB: 
102254732(AASS)
MYD: 
102770634(AASS)
PALE: 
102881018(AASS)
MDO: 
100016400(AASS)
SHR: 
100923009(AASS)
OAA: 
100076030(AASS)
GGA: 
417757(AASS)
MGP: 
TGU: 
100222251(AASS)
FAB: 
101818954(AASS)
PHI: 
102112915(AASS)
APLA: 
101793380(AASS)
FPG: 
101923487(AASS)
FCH: 
102047696(AASS)
CLV: 
102094241(AASS)
ASN: 
102376316(AASS)
AMJ: 
102574453(AASS)
PSS: 
102454542(AASS)
CMY: 
102948389(AASS)
ACS: 
PBI: 
XLA: 
444409(aass)
XTR: 
496923(aass)
DRE: 
556229(aass)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102353181(AASS)
CMK: 
103179368(aass)
BFO: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
552130(LKR)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_R02D3.1(R02D3.1)
CBR: 
NVE: 
HMG: 
TAD: 
AQU: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
CSV: 
RCU: 
POP: 
VVI: 
SLY: 
SOT: 
DOSA: 
Os02t0783700-01(Os02g0783700)
OBR: 
BDI: 
SBI: 
SORBI_04g035220(SORBIDRAFT_04g035220)
ZMA: 
541648(lkrsdh1)
SITA: 
ATR: 
s00129p00051020(AMTR_s00129p00051020)
SMO: 
PPP: 
GSL: 
CNE: 
CNB: 
CGI: 
LBC: 
CCI: 
SCM: 
MBR: 
DDI: 
DPP: 
DFA: 
DFA_03752(aass)
TET: 
PTI: 
TPS: 
PIF: 
EHX: 
NGR: 
PRW: 
STP: 
GFO: 
 » show all
Taxonomy
Reference
1  [PMID:4385118]
  Authors
Hutzler J, Dancis J.
  Title
Conversion of lysine to saccharopine by human tissues.
  Journal
Biochim. Biophys. Acta. 158 (1968) 62-9.
  Organism
Homo sapiens
Reference
2  [PMID:6434529]
  Authors
Markovitz PJ, Chuang DT, Cox RP.
  Title
Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities.
  Journal
J. Biol. Chem. 259 (1984) 11643-6.
  Organism
Bos taurus, Papio sp.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37256-26-1

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