| Entry |
|
|---|
| Name |
trimethylamine dehydrogenase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-NH group of donors;
With a flavin as acceptor
 |
|---|
| Sysname |
trimethylamine:electron-transferring flavoprotein oxidoreductase
(demethylating) |
|---|
| Reaction(IUBMB) |
trimethylamine + H2O + electron-transferring flavoprotein =
dimethylamine + formaldehyde + reduced electron-transferring
flavoprotein [RN:R02511] |
|---|
| Reaction(KEGG) |
R02511
 |
|---|
| Substrate |
trimethylamine [CPD:C00565];
H2O [CPD:C00001];
electron-transferring flavoprotein [CPD:C04253] |
|---|
| Product |
dimethylamine [CPD:C00543];
formaldehyde [CPD:C00067];
reduced electron-transferring flavoprotein [CPD:C04570] |
|---|
| Comment |
A number of alkyl-substituted derivatives of trimethylamine can also
act as electron donors; phenazine methosulfate and
2,6-dichloroindophenol can act as electron acceptors. Contains FAD
and a [4Fe-4S] cluster. |
|---|
| Pathway |
PATH: ec00680 Methane metabolism |
|---|
| Orthology |
KO: K00317 trimethylamine dehydrogenase |
|---|
| Genes |
CAL: CaO19.125(EBP1)
MSU: MS2010(nemA)
BUR: Bcep18194_C7137
RDE: RD1_4141(tmd) RD1_4142(tmd)
SAU: SA0311
SAV: SAV0322
SAM: MW0299
SAR: SAR0319
SAS: SAS0299
SAC: SACOL0392
SAB: SAB0272c
SAA: SAUSA300_0322
SAO: SAOUHSC_00302
SAJ: SaurJH9_0370
SAH: SaurJH1_0381
SAE: NWMN_0315
SHA: SH0268
SPY: SPy_1219
SPZ: M5005_Spy_0933
SPM: spyM18_1171
SPG: SpyM3_0859
SPS: SPs1059
SPJ: MGAS2096_Spy0992
SPF: SpyM50865
SPA: M6_Spy0922
SPB: M28_Spy0905
SAG: SAG1061
SAN: gbs1095
SAK: SAK_1150
MPU: MYPU_7720(baiH)
MMY: MSC_0526
MCP: MCAP_0450
MAA: MAG_0050
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:5116569]
Colby J, Zatman LJ.
The purification and properties of a bacterial trimethylamine
dehydrogenase.
Biochem. J. 121 (1971) 9P-10P.
Bacterium 4B6 |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:204297]
Steenkamp DJ, Singer TP.
Participation of the iron-sulphur cluster and of the covalently
bound coenzyme of trimethylamine dehydrogenase in catalysis.
Biochem. J. 169 (1978) 361-9.
methylotrophic bacterium |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:7592591]
Huang L, Rohlfs RJ, Hille R.
The reaction of trimethylamine dehydrogenase with electron
transferring flavoprotein.
J. Biol. Chem. 270 (1995) 23958-65.
Methylophilus methylotrophus |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:11756429]
Jones M, Talfournier F, Bobrov A, Grossmann JG, Vekshin N, Sutcliffe
MJ, Scrutton NS.
Electron transfer and conformational change in complexes of
trimethylamine dehydrogenase and electron transferring flavoprotein.
J. Biol. Chem. 277 (2002) 8457-65.
Methylophilus methylotrophus |
|---|
Reference
Authors
Title
Journal
|
5 [PMID:11192721]
Scrutton NS, Sutcliffe MJ.
Trimethylamine dehydrogenase and electron transferring flavoprotein.
Subcell. Biochem. 35 (2000) 145-81. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.5.8.2
IUBMB Enzyme Nomenclature: 1.5.8.2
ExPASy - ENZYME nomenclature database: 1.5.8.2
UM-BBD (Biocatalysis/Biodegradation Database): 1.5.8.2
BRENDA, the Enzyme Database: 1.5.8.2
CAS: 39307-09-0 |
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