| Entry |
|
|---|
| Name |
sarcosine dehydrogenase;
sarcosine N-demethylase;
monomethylglycine dehydrogenase;
sarcosine:(acceptor) oxidoreductase (demethylating) |
|---|
| Class |
Oxidoreductases;
Acting on the CH-NH group of donors;
With other acceptors
 |
|---|
| Sysname |
sarcosine:acceptor oxidoreductase (demethylating) |
|---|
| Reaction(IUBMB) |
sarcosine + acceptor + H2O = glycine + formaldehyde + reduced
acceptor [RN:R00611] |
|---|
| Reaction(KEGG) |
R00611
 |
|---|
| Substrate |
sarcosine [CPD:C00213];
acceptor [CPD:C00028];
H2O [CPD:C00001] |
|---|
| Product |
glycine [CPD:C00037];
formaldehyde [CPD:C00067];
reduced acceptor [CPD:C00030] |
|---|
| Cofactor |
FMN [CPD:C00061] |
|---|
| Comment |
A flavoprotein (FMN). |
|---|
| Pathway |
PATH: ec00260 Glycine, serine and threonine metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00314 sarcosine dehydrogenase |
|---|
| Genes |
HSA: 1757(SARDH)
PTR: 464828(SARDH)
MCC: 713289
MMU: 192166(Sardh)
RNO: 114123(Sardh)
CFA: 491277(SARDH)
BTA: 614603(SARDH)
SSC: 100153126
ECB: 100069193(SARDH)
MDO: 100018850
OAA: 100073946
GGA: 417146(SARDH)
DRE: 394103(sardh)
DME: Dmel_CG6385
DPO: Dpse_GA19555
NVE: NEMVE_v1g174872
AFM: AFUA_4G01150
PUB: SAR11_1221
MLO: mll5369 mlr1213 mlr1283
SME: SMc01662
RET: RHE_CH00088(ypch00035) RHE_PE00084(ype00032)
RLE: RL0097
BME: BMEI0684
SIL: SPO3396
SIT: TM1040_0434
RDE: RD1_4112
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13895406]
FRISELL WR, MACKENZIE CG.
Separation and purification of sarcosine dehydrogenase and
dimethylglycine dehydrogenase.
J. Biol. Chem. 237 (1962) 94-8.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:13716069]
HOSKINS DD, MACKENZIE CG.
Solubilization and electron transfer flavoprtein requirement of
mitochondrial sarcosine dehydrogenase and dimethylglycine
dehydrogenase.
J. Biol. Chem. 236 (1961) 177-83.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.5.99.1
IUBMB Enzyme Nomenclature: 1.5.99.1
ExPASy - ENZYME nomenclature database: 1.5.99.1
BRENDA, the Enzyme Database: 1.5.99.1
CAS: 37228-65-2 93389-49-2 |
|---|
