KEGG   ENZYME: 1.5.99.2Help
Entry
EC 1.5.99.2                 Enzyme                                 
Name dimethylglycine dehydrogenase;
N,N-dimethylglycine oxidase;
N,N-dimethylglycine:(acceptor) oxidoreductase (demethylating)
Class Oxidoreductases;
Acting on the CH-NH group of donors;
With other acceptors
BRITE hierarchy
Sysname N,N-dimethylglycine:acceptor oxidoreductase (demethylating)
Reaction(IUBMB) N,N-dimethylglycine + acceptor + H2O = sarcosine + formaldehyde +
reduced acceptor [RN:R01565]
Reaction(KEGG) R01565
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Substrate N,N-dimethylglycine [CPD:C01026];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Product sarcosine [CPD:C00213];
formaldehyde [CPD:C00067];
reduced acceptor [CPD:C00030]
Cofactor FAD [CPD:C00016]
Comment A flavoprotein.
Pathway PATH: ec00260  Glycine, serine and threonine metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K00315  dimethylglycine dehydrogenase
Genes HSA: 29958(DMGDH)
PTR: 471505(DMGDH)
MMU: 74129(Dmgdh)
RNO: 245961(Dmgdh)
CFA: 488935(DMGDH)
BTA: 504453(DMGDH)
ECB: 100073267
MDO: 100032620
TGU: 100231246
XLA: 446949
BFO: BRAFLDRAFT_280302
SPU: 587447
ISC: IscW_ISCW001817
CBR: CBG22093
BMY: Bm1_17220
NVE: NEMVE_v1g243380
HMG: 100209590
TAD: TRIADDRAFT_54121
REH: H16_B1955(gcvT3)
PUB: SAR11_1253
MLO: mll1517 mll1653 mll2449 mlr1280
SME: SMa1483 SMc01663
SMD: Smed_2198 Smed_5112
ATU: Atu1632
ATC: AGR_C_3012
ARA: Arad_3491 Arad_7067
AVI: Avi_2727
RLT: Rleg2_3310
RHI: NGR_b16530 NGR_c21820
SIL: SPO0207 SPO0544 SPO0564 SPO3400 SPOA0063
SIT: TM1040_0486 TM1040_1426 TM1040_2063
RSP: RSP_3566
RSH: Rsph17029_3249
RSQ: Rsph17025_3155
RSK: RSKD131_3734
JAN: Jann_0919 Jann_1481 Jann_1596 Jann_2805
RDE: RD1_0017 RD1_0019 RD1_0607 RD1_1345 RD1_3093 RD1_3434
PDE: Pden_1940
DSH: Dshi_1485 Dshi_2967
SWI: Swit_0939
Taxonomy
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:13895406]
FRISELL WR, MACKENZIE CG.
Separation and purification of sarcosine dehydrogenase and
dimethylglycine dehydrogenase.
J. Biol. Chem. 237 (1962) 94-8.
Rattus norvegicus [GN:rno]
Reference
  Authors
  Title


  Journal
  Organism
 2  [PMID:13716069]
HOSKINS DD, MACKENZIE CG.
Solubilization and electron transfer flavoprtein requirement of
mitochondrial sarcosine dehydrogenase and dimethylglycine
dehydrogenase.
J. Biol. Chem. 236 (1961) 177-83.
Rattus norvegicus [GN:rno]
Other DBs ExplorEnz - The Enzyme Database: 1.5.99.2
IUBMB Enzyme Nomenclature: 1.5.99.2
ExPASy - ENZYME nomenclature database: 1.5.99.2
BRENDA, the Enzyme Database: 1.5.99.2
CAS: 37256-30-7
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