KEGG   ENZYME: 1.6.1.1Help
Entry
EC 1.6.1.1                  Enzyme                                 
Name NAD(P)+ transhydrogenase (B-specific);
pyridine nucleotide transhydrogenase;
transhydrogenase;
NAD(P)+ transhydrogenase;
nicotinamide adenine dinucleotide (phosphate) transhydrogenase;
NAD+ transhydrogenase;
NADH transhydrogenase;
nicotinamide nucleotide transhydrogenase;
NADPH-NAD+ transhydrogenase;
pyridine nucleotide transferase;
NADPH-NAD+ oxidoreductase;
NADH-NADP+-transhydrogenase;
NADPH:NAD+ transhydrogenase;
H+-Thase;
non-energy-linked transhydrogenase;
NAD(P)+ transhydrogenase (B-specific)
Class Oxidoreductases;
Acting on NADH or NADPH;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname NADPH:NAD+ oxidoreductase (B-specific)
Reaction(IUBMB) NADPH + NAD+ = NADP+ + NADH [RN:R00112]
Reaction(KEGG) R00112
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Substrate NADPH [CPD:C00005];
NAD+ [CPD:C00003]
Product NADP+ [CPD:C00006];
NADH [CPD:C00004]
Cofactor FAD [CPD:C00016]
Comment The enzyme from Azotobacter vinelandii is a flavoprotein (FAD). It
is B-specific with respect to both NAD+ and NADP+. Also acts on
deamino coenzymes [cf. EC 1.6.1.2 NAD(P)+ transhydrogenase
(AB-specific)].
Pathway PATH: ec00760  Nicotinate and nicotinamide metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K00322  NAD(P) transhydrogenase
Genes NVE: NEMVE_v1g151545
AFM: AFUA_5G02780
PFA: PF14_0508
PFD: PFDG_02264
PFH: PFHG_00653
PYO: PY05907
PBE: PB001148.00.0
PKN: PKH_125300
PVX: PVX_117805
CPV: cgd8_2330
CHO: Chro.80274
TGO: TGME49_118650
TET: TTHERM_00314860
ECO: b3962(sthA)
ECJ: JW5551(sthA)
ECD: ECDH10B_4151(sthA)
EBW: BWG_3630(sthA)
ECE: Z5521(udhA)
ECS: ECs4891
ECF: ECH74115_5422(sthA)
ETW: ECSP_5031(sthA)
ECG: E2348C_4276(sthA)
ECC: c4923(udhA)
ECI: UTI89_C4555(sthA)
ECP: ECP_4177
ECV: APECO1_2503(udhA)
ECW: EcE24377A_4502(sthA)
ECX: EcHS_A4196(sthA)
ECM: EcSMS35_4408(sthA)
ECY: ECSE_4257
ECL: EcolC_4054
ECK: EC55989_4447(sthA)
ECQ: ECED1_4669(sthA)
ECR: ECIAI1_4172(sthA)
ECT: ECIAI39_3027(sthA)
ECZ: ECS88_4419(sthA)
EUM: ECUMN_4493(sthA)
ELF: LF82_2193(sthA)
EBL: B21_03796(udhA)
EBD: ECBD_4062
EBR: ECB_03847(udhA)
EOH: ECO103_4720(sthA)
EOI: ECO111_4787(sthA)
EOJ: ECO26_5079(sthA)
EFE: EFER_3800(sthA)
STY: STY3748(udhA)
STT: t3499(udhA)
SPT: SPA3964(udhA)
SEK: SSPA3689
SPQ: SPAB_05111
SEI: SPC_4234(udhA)
SEC: SC4015(udhA)
SEH: SeHA_C4454(sthA)
SEE: SNSL254_A4457(sthA)
SEW: SeSA_A4336(sthA)
SEA: SeAg_B4367(sthA)
SED: SeD_A4531(sthA)
SEG: SG3290(udhA)
SET: SEN3920(udhA)
SES: SARI_03538
STM: STM4126(udhA)
YPE: YPO3914(sthA)
YPK: y0321(udhA)
YPM: YP_3134(sthA)
YPA: YPA_0108
YPN: YPN_0053
YPG: YpAngola_A0118(sthA)
YPP: YPDSF_3526
YPS: YPTB0121(sthA)
YPI: YpsIP31758_0137(sthA)
YPY: YPK_4078
YPB: YPTS_0127
YEN: YE0134(sth)
SFL: SF4044(udhA)
SFX: S3700(udhA)
SFV: SFV_4035(udhA)
SSN: SSON_4135(udhA)
SBO: SBO_3981(udhA)
SBC: SbBS512_E4447(sthA)
SDY: SDY_3797(udhA)
ECA: ECA4242(sthA)
PCT: PC1_0188
PWA: Pecwa_0194
ETA: ETA_01400(udhA)
PLU: plu4739(sthA)
PAY: PAU_04232(sthA)
SGL: SG2157
ENT: Ent638_4024
ESA: ESA_03804
CTU: Ctu_01970(sthA)
KPN: KPN_04251(udhA)
KPE: KPK_5431(sthA)
KPU: KP1_0116(udhA)
CKO: CKO_03031
SPE: Spro_4774
PMR: PMI3242(sthA)
EIC: NT01EI_3841
ETR: ETAE_3475
HDE: HDEF_0374(sthA)
DDA: Dd703_3787
DDC: Dd586_3928
DZE: Dd1591_0128
VCH: VC0151
VCO: VC0395_A2370
VCM: VCM66_0151(dudE)
VCJ: VCD_001608
VVU: VV1_1168
VVY: VV0126
VPA: VP2942
VHA: VIBHAR_00265
VSP: VS_3003
VEX: VEA_002152
VFI: VF_2439(sthA)
VFM: VFMJ11_2563
VSA: VSAL_I2890(sthA)
PPR: PBPRA3468
PAE: PA2991(sth)
PAU: PA14_25390(sth)
PAP: PSPA7_2169(sth)
PAG: PLES_20711(sth)
PPU: PP_2151(sthA)
PPF: Pput_3591
PPG: PputGB1_1692
PPW: PputW619_1668
PST: PSPTO_2106(sthA)
PSB: Psyr_1901
PSP: PSPPH_1856(sthA)
PFL: PFL_1958(sthA)
PFO: Pfl01_3862
PFS: PFLU1569(sthA)
PEN: PSEEN3711(sthA)
PMY: Pmen_1603
PSA: PST_2647(sthA)
CJA: CJA_1772
AVN: Avin_14670(sthA)
PAR: Psyc_1333(sthA)
PCR: Pcryo_1036
PRW: PsycPRwf_0951
ACI: ACIAD2274(sthA)
ACB: A1S_2328
ABM: ABSDF1195(sthA)
ABY: ABAYE1147(sthA)
ABC: ACICU_02531
ABN: AB57_2762
ABB: ABBFA_001112
ILO: IL0322(udhA)
CPS: CPS_0334(sthA)
PHA: PSHAa2898(sthA)
SDE: Sde_1805 Sde_2516
MAQ: Maqu_1923
AMC: MADE_03582
PIN: Ping_0118
TTU: TERTU_0708 TERTU_1957
LPN: lpg0876(pntAa)
FTU: FTT_0684c(sthA)
FTF: FTF0684c(sthA)
FTW: FTW_1044(sthA)
FTL: FTL_0960
FTH: FTH_0938
FTA: FTA_1011(udhA)
FTM: FTM_1174(udhA)
FTN: FTN_0999(udhA)
FPH: Fphi_1588
AEH: Mlg_0914
HCH: HCH_02051 HCH_02695
CSA: Csal_1577
ABO: ABO_1570(sth)
MMW: Mmwyl1_1719
BMA: BMA2367
BMV: BMASAVP1_A0281
BML: BMA10229_A1143
BMN: BMA10247_2547
BPS: BPSL2886(pntAB)
BPM: BURPS1710b_3393(pntAB) BURPS1710b_3394(pntAA)
BPD: BURPS668_3351
ADE: Adeh_3831
ACP: A2cp1_3972
AFW: Anae109_3945
ANK: AnaeK_3894
MXA: MXAN_2411(sthA)
SCL: sce2004
HOH: Hoch_5091
MLO: mlr8366
SME: SMc00300
SMD: Smed_1462
ATU: Atu1661(sthA)
ATC: AGR_C_3055
ARA: Arad_2151
AVI: Avi_2476(sthA)
RET: RHE_CH01846(ypch00610)
REC: RHECIAT_CH0001933(sthA)
RLE: RL2066(sthA)
RLT: Rleg2_1509
RLG: Rleg_1707
RHI: NGR_c13940
BJA: bll0896
MSL: Msil_3303
SIL: SPO3828(sthA)
SIT: TM1040_3447
GBE: GbCGDNIH1_1246
MTU: Rv2713(sthA)
MTC: MT2786
MRA: MRA_2741(sthA)
MTF: TBFG_12727
MTB: TBMG_01261(TBMG_01261.1)
MBO: Mb2732(sthA)
MBB: BCG_2726(sthA)
MBT: JTY_2720(sthA)
MPA: MAP2829
MAV: MAV_3606
MSM: MSMEG_2748(sthA)
MVA: Mvan_2448
MAB: MAB_3032
MMI: MMAR_2000(sthA)
RER: RER_47360(sthA)
TCU: Tcur_2047
SRO: Sros_6317
FRA: Francci3_3883
FRE: Franean1_0843
FAL: FRAAL6153(sthA)
NML: Namu_0212 Namu_5306
AMI: Amir_5462
PCU: pc0725(udhA)
LBI: LEPBI_II0144
LBF: LBF_4139(lpdA)
ABA: Acid345_3223
ACA: ACP_2380(sthA)
SUS: Acid_1071
RBA: RB5717(sthA)
Taxonomy
Structures PDB: 1D4O  1DJL  1E3T  1F8G  1HZZ  1L7D  1L7E  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:13412660]
HUMPHREY GF.
The distribution and properties of transhydrogenase from animal
tissues.
Biochem. J. 65 (1957) 546-50.
Pseudomonas fluorescens
Reference
  Authors
  Title

  Journal
 2  [PMID:3157549]
You KS.
Stereospecificity for nicotinamide nucleotides in enzymatic and
chemical hydride transfer reactions.
CRC. Crit. Rev. Biochem. 17 (1985) 313-451.
Other DBs ExplorEnz - The Enzyme Database: 1.6.1.1
IUBMB Enzyme Nomenclature: 1.6.1.1
ExPASy - ENZYME nomenclature database: 1.6.1.1
BRENDA, the Enzyme Database: 1.6.1.1
CAS: 9014-18-0
DBGET integrated database retrieval system