| Entry |
|
|---|
| Name |
cytochrome-b5 reductase;
cytochrome b5 reductase;
dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase;
reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase;
NADH-ferricytochrome b5 oxidoreductase;
NADH-cytochrome b5 reductase;
NADH 5alpha-reductase ;
NADH-cytochrome-b5 reductase |
|---|
| Class |
Oxidoreductases;
Acting on NADH or NADPH;
With a heme protein as acceptor
 |
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| Sysname |
NADH:ferricytochrome-b5 oxidoreductase |
|---|
| Reaction(IUBMB) |
NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5
[RN:R00100] |
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| Reaction(KEGG) |
R00100
 |
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| Substrate |
NADH [CPD:C00004];
ferricytochrome b5 [CPD:C00996] |
|---|
| Product |
NAD+ [CPD:C00003];
H+ [CPD:C00080];
ferrocytochrome b5 [CPD:C00999] |
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| Cofactor |
FAD [CPD:C00016] |
|---|
| Comment |
A flavoprotein (FAD). |
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| Pathway |
PATH: ec00520 Amino sugar and nucleotide sugar metabolism |
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| Orthology |
KO: K00326 cytochrome-b5 reductase |
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| Genes |
HSA: 1727(CYB5R3) 51706(CYB5R1)
PTR: 451005 458883(CYB5R3) 740001
MCC: 704519 714058
MMU: 109754(Cyb5r3) 72017(Cyb5r1)
RNO: 25035(Cyb5r3) 304805(Cyb5r1)
CFA: 474479(CYB5R3) 606823(CYB5R1)
BTA: 515773(CYB5R3) 516287(CYB5R1)
ECB: 100064917 100071050
MDO: 100012151 100027533 100031988
OAA: 100088583
GGA: 418220(RCJMB04_4p8)
TGU: 100228774
XLA: 380169(dia1)
XTR: 100170571
DRE: 324560(cyb5r3) 336553(dia1) 553685(cyb5r4) 751641(cyb5r2)
DME: Dmel_CG5946
DPO: Dpse_GA19251
CEL: T05H4.4 T05H4.5
ATH: AT5G17770(ATCBR)
OSA: 4327126(Os01g0174300) 4327480(Os01g0814900)
4339153(Os05g0488900)
OLU: OSTLU_38305 OSTLU_6009
CME: CMS286C
SCE: YIL043C(CBR1) YKL150W(MCR1)
AGO: AGOS_ACR054C AGOS_ADL087W
KLA: KLLA0D04488g KLLA0F27621g
DHA: DEHA0E08745g
PIC: PICST_44816(CBR2) PICST_45522(CBR3) PICST_68997(CBR1)
CGR: CAGL0E06424g CAGL0L00847g
YLI: YALI0D04983g YALI0D11330g
SPO: SPAC17H9.12c SPCC970.03
NCR: NCU03112 NCU08060
MGR: MGG_03708 MGG_09315
ANI: AN0432.2 AN8920.2
AFM: AFUA_1G04540 AFUA_3G03970 AFUA_5G10060
AOR: AO090001000630 AO090003000873 AO090011000149
ANG: An01g03570 An01g09750
CNE: CNM00240
DDI: DDBDRAFT_0218707
PFA: PF13_0353
PYO: PY03083
TAN: TA13765
TBR: Tb11.01.7190 Tb11.02.1230 Tb11.47.0018 Tb927.5.1470
Tb927.7.2700 Tb927.7.2710
TCR: 511047.40 511817.40 511859.170
LMA: LmjF13.1060 LmjF15.0050 LmjF22.0770 LmjF22.0780
NOC: Noc_1586
NPH: NP1230A
 |
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| Structures |
PDB: 1I7P 1IB0 1NDH 1QX4 1UMK 2EIX |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13563476]
MAHLER HR, RAW I, MOLINARI R, DO AMARAL DF.
Studies of electron transport enzymes. II. Isolation and some
properties of a cytochrome-specific reduced diphosphopyridine
nucleotide dehydrogenase from pig liver.
J. Biol. Chem. 233 (1958) 230-9.
Sus scofa [GN:ssc] |
|---|
Reference
Authors
Title
Journal
|
2
Strittmatter, P.
Microsomal cytochrome b5 and cytochrome b5 reductase.
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd
ed., vol. 8, Academic Press, New York, 1963, p. 113-145. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13475360]
STRITTMATTER P, VELICK SF.
The purification and properties of microsomal cytochrome reductase.
J. Biol. Chem. 228 (1957) 785-99.
Rattus norvegicus [GN:rno], Oryctolagus cuniculus |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.6.2.2
IUBMB Enzyme Nomenclature: 1.6.2.2
ExPASy - ENZYME nomenclature database: 1.6.2.2
BRENDA, the Enzyme Database: 1.6.2.2
CAS: 9032-25-1 |
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