KEGG   ENZYME: 1.6.3.1Help
Entry
EC 1.6.3.1                  Enzyme                                 
Name
NAD(P)H oxidase;
THOX2;
ThOX;
dual oxidase;
p138tox;
thyroid NADPH oxidase;
thyroid oxidase;
thyroid oxidase 2;
NADPH oxidase
Class
Oxidoreductases;
Acting on NADH or NADPH;
With oxygen as acceptor
BRITE hierarchy
Sysname
NAD(P)H:oxygen oxidoreductase
Reaction(IUBMB)
NAD(P)H + H+ + O2 = NAD(P)+ + H2O2 [RN:R07171 R07172]
Reaction(KEGG)
Substrate
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O2 [CPD:C00027]
Comment
Requires FAD, heme and calcium. When calcium is present, this transmembrane glycoprotein generates H2O2 by transfering electrons from intracellular NAD(P)H to extracellular molecular oxygen. The electron bridge within the enzyme contains one molecule of FAD and probably two heme groups. This flavoprotein is expressed at the apical membrane of thyrocytes, and provides H2O2 for the thyroid peroxidase-catalysed biosynthesis of thyroid hormones.
Orthology
K13411  
dual oxidase
Genes
HSA: 
50506(DUOX2) 53905(DUOX1)
PTR: 
453395(DUOX2) 467673(DUOX1)
PPS: 
100974723(DUOX1) 100978429(DUOX2)
GGO: 
101137548(DUOX1) 101139037(DUOX2)
PON: 
100445893(DUOX2) 100447745(DUOX1)
MCC: 
713126(DUOX1) 713906
MMU: 
214593(Duox2) 99439(Duox1)
RNO: 
266807(Duox1) 79107(Duox2)
CFA: 
403719(DUOX2) 403720(DUOX1)
FCA: 
101087408(DUOX2) 101091374(DUOX1)
BTA: 
510409(DUOX1) 785698(DUOX2)
SSC: 
397060(DUOX2) 397177(DUOX1)
ECB: 
100070541 100070566(DUOX2)
MDO: 
100012836(DUOX1)
SHR: 
100931267(DUOX2) 100932050(DUOX1)
OAA: 
100089154
GGA: 
427482(DUOX2)
MGP: 
100538948
TGU: 
100218721(DUOX2)
ACS: 
100562649
XTR: 
100486194
DRE: 
565097(duox)
TRU: 
100124426(duox)
OLA: 
101160477
BFO: 
BRAFLDRAFT_129071
CIN: 
100170038(duox-b) 100170039(duox-a)
SPU: 
588656(duox1)
DME: 
Dmel_CG3131(Duox)
DPO: 
Dpse_GA16169
DAN: 
Dana_GF14917
DER: 
Dere_GG24488
DPE: 
Dper_GL15451
DSE: 
Dsec_GM18194 Dsec_GM18195
DSI: 
Dsim_GD22800
DWI: 
Dwil_GK24757
DYA: 
Dyak_GE15013
DGR: 
Dgri_GH25126
DMO: 
Dmoj_GI12101
DVI: 
Dvir_GJ14144
AGA: 
AgaP_AGAP009978(DUOX)
AAG: 
AaeL_AAEL007563
CQU: 
CpipJ_CPIJ003117
AME: 
551970(Duox)
NVI: 
100123854(NV11842)
TCA: 
659451 660520
API: 
100160850
PHU: 
Phum_PHUM454140
ISC: 
IscW_ISCW007865
CEL: 
CELE_F56C11.1(bli-3)
CBR: 
CBG05103(Cbr-bli-3)
BMY: 
Bm1_45640
TSP: 
Tsp_00940
AQU: 
100637823
CSV: 
101219908
 » show all
Taxonomy
Reference
1  [PMID:12110737]
  Authors
Moreno JC, Bikker H, Kempers MJ, van Trotsenburg AS, Baas F, de Vijlder JJ, Vulsma T, Ris-Stalpers C.
  Title
Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism.
  Journal
N. Engl. J. Med. 347 (2002) 95-102.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:11822874]
  Authors
De Deken X, Wang D, Dumont JE, Miot F.
  Title
Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system.
  Journal
Exp. Cell. Res. 273 (2002) 187-96.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:10806195]
  Authors
De Deken X, Wang D, Many MC, Costagliola S, Libert F, Vassart G, Dumont JE, Miot F.
  Title
Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.
  Journal
J. Biol. Chem. 275 (2000) 23227-33.
  Organism
Homo sapiens [GN:hsa]
Reference
4  [PMID:10601291]
  Authors
Dupuy C, Ohayon R, Valent A, Noel-Hudson MS, Deme D, Virion A.
  Title
Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas.
  Journal
J. Biol. Chem. 274 (1999) 37265-9.
  Organism
Homo sapiens [GN:hsa]
Reference
5  [PMID:10401672]
  Authors
Leseney AM, Deme D, Legue O, Ohayon R, Chanson P, Sales JP, Pires de Carvalho D, Dupuy C, Virion A.
  Title
Biochemical characterization of a Ca2+/NAD(P)H-dependent H2O2 generator in human thyroid tissue.
  Journal
Biochimie. 81 (1999) 373-80.
  Organism
Homo sapiens [GN:hsa]
Reference
6  [PMID:1995628]
  Authors
Dupuy C, Virion A, Ohayon R, Kaniewski J, Deme D, Pommier J.
  Title
Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane.
  Journal
J. Biol. Chem. 266 (1991) 3739-43.
  Organism
Sus scofa [GN:ssc]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
77106-92-4
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