KEGG   ENZYME: 1.6.99.5Help
Entry
EC 1.6.99.5                 Enzyme                                 
Name NADH dehydrogenase (quinone);
reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase;
NADH-quinone oxidoreductase;
DPNH-menadione reductase;
D-diaphorase;
NADH2 dehydrogenase (quinone)
Class Oxidoreductases;
Acting on NADH or NADPH;
With other acceptors
BRITE hierarchy
Sysname NADH:(quinone-acceptor) oxidoreductase
Reaction(IUBMB) NADH + H+ + acceptor = NAD+ + reduced acceptor [RN:R00281]
Reaction(KEGG) R00281
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Substrate NADH [CPD:C00004];
H+ [CPD:C00080];
acceptor [CPD:C00028]
Product NAD+ [CPD:C00003];
reduced acceptor [CPD:C00030]
Inhibitor AMP [CPD:C00020];
2,4-Dinitrophenol [CPD:C02496]
Comment Menaquinone can act as acceptor. Inhibited by AMP and
2,4-dinitrophenol but not by dicoumarol or folic acid derivatives.
Pathway PATH: ec00190  Oxidative phosphorylation
Orthology KO: K05903  NADH dehydrogenase (quinone)
Genes PPF: Pput_3553
PMY: Pmen_0388
PSA: PST_0383 PST_0384
SFR: Sfri_2286 Sfri_2288 Sfri_2741 Sfri_2742
SSE: Ssed_1397 Ssed_1398
MAQ: Maqu_2855
NOC: Noc_1250 Noc_1280 Noc_1281
AEH: Mlg_0743 Mlg_0744
HHA: Hhal_0812 Hhal_0813 Hhal_2035
TGR: Tgr7_2529
AFE: Lferr_1807
AFR: AFE_2149(hyfB)
REU: Reut_A0618 Reut_B4588 Reut_B4652
REH: H16_A2196
RME: Rmet_4300
BML: BMA10229_0954(nuoB-2)
BMN: BMA10247_A1924(nuoB-2)
BVI: Bcep1808_0953
BUR: Bcep18194_A4145
BCN: Bcen_0553
BCH: Bcen2424_1032
BAM: Bamb_0896
BPH: Bphy_6065
RFR: Rfer_3270 Rfer_3276 Rfer_3292
POL: Bpro_0916 Bpro_2804
PNA: Pnap_0825
AJS: Ajs_3471
VEI: Veis_2384
HAR: HEAR0357 HEAR3433
NMU: Nmul_A0709
MFA: Mfla_0721
GUR: Gura_0803 Gura_0892 Gura_2653 Gura_4066
PPD: Ppro_0070 Ppro_0336 Ppro_0587 Ppro_0588 Ppro_0589 Ppro_1489
     Ppro_1636 Ppro_2787 Ppro_2795 Ppro_3180 Ppro_3530 Ppro_3531
     Ppro_3532
DVL: Dvul_0969 Dvul_2501
ADE: Adeh_3654 Adeh_3655
SCL: sce8744(ndhF2)
RLE: pRL110297(hyfB)
RPB: RPB_0725 RPB_1260
RPC: RPC_0929 RPC_4506 RPC_4646
RPD: RPD_3855
RPE: RPE_0952 RPE_4648
MEX: Mext_4405
MET: M446_2353
RSQ: Rsph17025_2854
JAN: Jann_2559 Jann_3695
PDE: Pden_2857
MMR: Mmar10_0890 Mmar10_0891 Mmar10_2683
HNE: HNE_0735
NAR: Saro_0733
SWI: Swit_1474
ACR: Acry_0605 Acry_0840 Acry_1396
RRU: Rru_A0315 Rru_A0318 Rru_A0320 Rru_A1420 Rru_A1634
MGM: Mmc1_2210
CTH: Cthe_3024
CSC: Csac_1534
MJL: Mjls_4493 Mjls_4495
CEF: CE1396 CE1397
ART: Arth_3659 Arth_4496 Arth_4498
NCA: Noca_4469
ACE: Acel_0729
STP: Strop_0771 Strop_0773
RXY: Rxyl_0123 Rxyl_0125 Rxyl_1798 Rxyl_3145 Rxyl_3148
SUS: Acid_5018
SYF: Synpcc7942_0279
PVI: Cvib_1257
DEB: DehaBAV1_0778 DehaBAV1_0782 DehaBAV1_1318 DehaBAV1_1321
RRS: RoseRS_2102
RCA: Rcas_1768
MMQ: MmarC5_1781
MHU: Mhun_1741 Mhun_1819 Mhun_1822
MLA: Mlab_1624
MEM: Memar_0364
MBN: Mboo_0024 Mboo_1127
MPL: Mpal_2724
RCI: RCIX1882(echA) RCIX2387
SMR: Smar_0028 Smar_0645
TPE: Tpen_0180 Tpen_0184 Tpen_0188 Tpen_1077
Taxonomy
Structures PDB: 2FUG  3I9V  3IAM  3IAS  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:4388793]
Koli AK, Yearby C, Scott W, Donaldson KO.
Purification and properties of three separate menadione reductases
from hog liver.
J. Biol. Chem. 244 (1969) 621-9.
Sus scofa [GN:ssc]
Other DBs ExplorEnz - The Enzyme Database: 1.6.99.5
IUBMB Enzyme Nomenclature: 1.6.99.5
ExPASy - ENZYME nomenclature database: 1.6.99.5
BRENDA, the Enzyme Database: 1.6.99.5
CAS: 37256-36-3
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