KEGG   ENZYME: 1.7.1.7Help
Entry
EC 1.7.1.7                  Enzyme                                 
Name GMP reductase;
guanosine 5'-monophosphate reductase;
NADPH:GMP oxidoreductase (deaminating);
guanosine monophosphate reductase;
guanylate reductase;
NADPH2:guanosine-5'-phosphate oxidoreductase (deaminating);
guanosine 5'-phosphate reductase
Class Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname inosine-5'-phosphate:NADP+ oxidoreductase (aminating)
Reaction(IUBMB) inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH
+ H+ [RN:R01134]
Reaction(KEGG) R01134
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Substrate inosine 5'-phosphate [CPD:C00130];
NH3 [CPD:C00014];
NADP+ [CPD:C00006]
Product guanosine 5'-phosphate [CPD:C00144];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Pathway PATH: ec00230  Purine metabolism
Orthology KO: K00364  GMP reductase
Genes HSA: 2766(GMPR) 51292(GMPR2)
PTR: 462453(GMPR) 745051(GMPR2)
MCC: 715719(GMPR2)
MMU: 105446(Gmpr2) 66355(Gmpr)
RNO: 117533(Gmpr)
CFA: 488231(GMPR)
BTA: 515837(GMPR2) 533000(GMPR)
SSC: 100154068 100154573
ECB: 100054670(GMPR2) 100065723
MDO: 100025714 100030802
OAA: 100080000
GGA: 420842(RCJMB04_19j20)
TGU: 100228013
XLA: 444486
XTR: 594932(gmpr2)
DRE: 553639(gmpr) 560009
BFO: BRAFLDRAFT_268787
CIN: 100182436
SPU: 591487 756209
AME: 552316
NVI: 100119268
API: 100162173(Gmpr2)
ISC: IscW_ISCW019974
CEL: F32D1.5
BMY: Bm1_33255
NVE: NEMVE_v1g227565
HMG: 100202973
TAD: TRIADDRAFT_63276
MBR: MONBRDRAFT_16151
TAN: TA21065
TPV: TP01_0363
BBO: BBOV_IV005560
ECO: b0104(guaC)
ECJ: JW0101(guaC)
ECD: ECDH10B_0085(guaC)
EBW: BWG_0098(guaC)
ECE: Z0114(guaC)
ECS: ECs0108
ECF: ECH74115_0111(guaC)
ETW: ECSP_0106(guaC)
ECG: E2348C_0108(guaC)
ECC: c0124(guaC)
ECI: UTI89_C0112(guaC)
ECP: ECP_0105
ECV: APECO1_1884(guaC)
ECW: EcE24377A_0106(guaC)
ECX: EcHS_A0109(guaC)
ECM: EcSMS35_0108(guaC)
ECY: ECSE_0105
ECL: EcolC_3554
ECK: EC55989_0098(guaC)
ECQ: ECED1_0103(guaC)
ECR: ECIAI1_0102(guaC)
ECT: ECIAI39_0105(guaC)
ECZ: ECS88_0107(guaC)
EUM: ECUMN_0102(guaC)
ELF: LF82_0955(guaC)
EBL: B21_00103(guaC)
EBD: ECBD_3514
EBR: ECB_00104(guaC)
EOH: ECO103_0105(guaC)
EOI: ECO111_0106(guaC)
EOJ: ECO26_0107(guaC)
EFE: EFER_0125(guaC)
STY: STY0163(guaC)
STT: t0147(guaC)
SPT: SPA0145(guaC)
SEK: SSPA0141
SPQ: SPAB_00176
SEI: SPC_0152(guaC)
SEC: SC0140(guaC)
SEH: SeHA_C0155(guaC)
SEE: SNSL254_A0154(guaC)
SEW: SeSA_A0158(guaC)
SEA: SeAg_B0161(guaC)
SED: SeD_A0153(guaC)
SEG: SG0143(guaC)
SET: SEN0145(guaC)
SES: SARI_02854
STM: STM0141(guaC)
YPE: YPO3428(guaC)
YPK: y0758(guaC)
YPM: YP_0256(guaC)
YPA: YPA_2930
YPN: YPN_0660
YPG: YpAngola_A1044(guaC)
YPP: YPDSF_2926
YPS: YPTB0703(guaC)
YPI: YpsIP31758_3373(guaC)
YPY: YPK_3501
YPB: YPTS_0732
YEN: YE0686(guaC)
SFL: SF0101(guaC)
SFX: S0103(guaC)
SFV: SFV_0096(guaC)
SSN: SSON_0112(guaC)
SBO: SBO_0092(guaC)
SBC: SbBS512_E0097(guaC)
SDY: SDY_0134(guaC)
ECA: ECA3801(guaC)
PCT: PC1_3578
PWA: Pecwa_3765
ETA: ETA_07990(guaC)
BUC: BU204(guaC)
BAS: BUsg198(guaC)
BAB: bbp188(guaC)
BAP: BUAP5A_201(guaC)
BAU: BUAPTUC7_203(guaC)
ENT: Ent638_0649
ESA: ESA_03234
CTU: Ctu_07370(guaC)
KPN: KPN_00107(guaC)
KPE: KPK_4633(guaC)
KPU: KP1_0928(guaC)
CKO: CKO_03271
SPE: Spro_0775
EIC: NT01EI_0750
ETR: ETAE_0651(guaC)
DDA: Dd703_0663
DDC: Dd586_3518
DZE: Dd1591_0624
VCH: VCA0197
VCO: VC0395_1080(guaC)
VCM: VCM66_A0193(guaC)
VCJ: VCD_000053
VVU: VV2_0712
VVY: VVA1179
VPA: VPA1159
VHA: VIBHAR_06224
VSP: VS_II1110
VEX: VEA_000471
VFI: VF_A0695(guaC)
VFM: VFMJ11_A0782(guaC)
VSA: VSAL_II0501(guaC)
PPR: PBPRB1716
SPL: Spea_4233
SHL: Shal_4281
AHA: AHA_3225(guaC)
ASA: ASA_1088(guaC)
TAU: Tola_2494
CVI: CV_2922
RFR: Rfer_3037
POL: Bpro_1718
PNA: Pnap_1472
AAV: Aave_1911
AJS: Ajs_3326
VEI: Veis_1695
DAC: Daci_5332
DIA: Dtpsy_2679
VAP: Vapar_1534
CTT: CtCNB1_0911
HAR: HEAR2601(guaC)
MMS: mma_2838(guaC)
LCH: Lcho_2764
HPY: HP0854
HPJ: jhp0790(guaC)
HPA: HPAG1_0838
HPS: HPSH_02530
HPG: HPG27_810
HPP: HPP12_0855
HPB: HELPY_0500(guaC)
GBM: Gbem_0096
GEO: Geob_1174
GEM: GM21_0078
RPA: RPA4561
RPB: RPB_0217
RPD: RPD_0604
RPE: RPE_0636
RPT: Rpal_5041
RRU: Rru_A1958
BSU: BSU32130(guaC)
BAN: BA5705(guaC)
BAR: GBAA5705(guaC)
BAA: BA_0563
BAT: BAS5309
BAH: BAMEG_5753(guaC)
BAI: BAA_5736(guaC)
BCE: BC5452
BCA: BCE_5594(guaC)
BCZ: BCZK5151(guaC)
BCR: BCAH187_A5640(guaC)
BCB: BCB4264_A5578(guaC)
BCU: BCAH820_5550(guaC)
BCG: BCG9842_B5369(guaC)
BCQ: BCQ_5302(guaC)
BCX: BCA_5607(guaC)
BCY: Bcer98_3971
BTK: BT9727_5137(guaC)
BTL: BALH_4963(guaC)
BWE: BcerKBAB4_5249
BLI: BL05105(guaC)
BLD: BLi01200(guaC)
BCL: ABC3216(guaC)
BAY: RBAM_029180(guaC)
OIH: OB1310
SAU: SA1172
SAV: SAV1337
SAW: SAHV_1326
SAM: MW1224
SAR: SAR1347
SAS: SAS1277
SAC: SACOL1371(guaC)
SAB: SAB1195
SAA: SAUSA300_1235(guaC)
SAO: SAOUHSC_01330
SAJ: SaurJH9_1398
SAH: SaurJH1_1425
SAE: NWMN_1249
SAD: SAAV_1317(guaC)
SEP: SE1019
SER: SERP0906(guaC)
SHA: SH1570
SSP: SSP1420
SCA: Sca_0978(guaC)
LSP: Bsph_4694
ESI: Exig_1681
EAT: EAT1b_1825
LLA: L158186(guaC)
LLK: LLKF_1170(guaC)
LLC: LACR_1256
LLM: llmg_1412(guaC)
SPY: SPy_1135
SPZ: M5005_Spy_0857(guaC)
SPM: spyM18_1095
SPG: SpyM3_0793
SPS: SPs0992
SPH: MGAS10270_Spy0971(guaC)
SPI: MGAS10750_Spy1006(guaC)
SPJ: MGAS2096_Spy0931(guaC)
SPK: MGAS9429_Spy0974(guaC)
SPF: SpyM50933
SPA: M6_Spy0853
SPB: M28_Spy0831(guaC)
SOZ: Spy49_0885
SPN: SP_1249
SPD: SPD_1107(guaC)
SPR: spr1128(guaC)
SPW: SPCG_1054(guaC)
SPX: SPG_1140(guaC)
SNE: SPN23F_11440
SPV: SPH_1365(guaC)
SNM: SP70585_1312(guaC)
SJJ: SPJ_1163(guaC)
SPP: SPP_1287(guaC)
SNT: SPT_0979(guaC)
SAG: SAG1087(guaC)
SAN: gbs1154
SAK: SAK_1172(guaC)
SSU: SSU05_0815
SSV: SSU98_0815
SSB: SSUBM407_1074
SSI: SSU0760
SSS: SSUSC84_0724
SGO: SGO_1159(guaC)
SEQ: SZO_09290
SEZ: Sez_1036(guaC)
SEU: SEQ_1153
SUB: SUB0865
SDS: SDEG_0894(guaC)
LPL: lp_3271(guaC)
LPJ: JDM1_2625(guaC)
LJO: LJ0441
LJF: FI9785_463(guaC)
LAC: LBA1893
LSA: LSA0476(guaC)
LSL: LSL_1139(guaC)
LDB: Ldb0292(guaC)
LBU: LBUL_0246
LBR: LVIS_0226
LCA: LSEI_0911
LCB: LCABL_10240(guaC)
LGA: LGAS_0389
LRE: Lreu_0068
LRF: LAR_0065
LHE: lhv_2031
LRH: LGG_00874(guaC)
LRL: LC705_00924(guaC)
PPE: PEPE_0595
EFA: EF2429(guaC)
OOE: OEOE_0535
CAC: CAC3471
VPR: Vpar_1301
MMY: MSC_0050(guaC)
ACL: ACL_0793(guaC)
MFL: Mfl170
FRA: Francci3_1752
FJO: Fjoh_3408
FBA: FIC_02569
EMI: Emin_1029
NPH: NP3080A(guaB_2)
TPE: Tpen_1064
Taxonomy
Structures PDB: 1YPF  2A1Y  2A7R  2BLE  2BWG  2BZN  2C6Q  
Reference
  Authors
  Title
  Journal
  Organism
 1  [PMID:4149840]
Mackenzie JJ, Sorensen LB.
Guanosine 5'-phosphate reductase of human erythrocytes.
Biochim. Biophys. Acta. 327 (1973) 282-94.
Homo sapiens [GN:hsa]
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:14419794]
MAGER J, MAGASNIK B.
Guanosine 5'-phosphate reductase and its role in the interconversion
of purine nucleotides.
J. Biol. Chem. 235 (1960) 1474-8.
Escherichia coli [GN:eco], Klebsiella pneumoniae [GN:kpn]
Other DBs ExplorEnz - The Enzyme Database: 1.7.1.7
IUBMB Enzyme Nomenclature: 1.7.1.7
ExPASy - ENZYME nomenclature database: 1.7.1.7
BRENDA, the Enzyme Database: 1.7.1.7
CAS: 9029-32-7
DBGET integrated database retrieval system